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Cell culture system, method for the production thereof and use in preclinical testing

A cell culture, pre-clinical technology, applied in the field of cell culture system, can solve the problem of increased requirements and achieve the effect of avoiding abnormal over-concentration

Inactive Publication Date: 2009-09-23
EDI实验和诊断免疫学有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

On the contrary, however, the nature of preclinical active substance screening is continuing to increase due to possible clinical risks and often continuously increasing costs for drug development

Method used

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  • Cell culture system, method for the production thereof and use in preclinical testing
  • Cell culture system, method for the production thereof and use in preclinical testing
  • Cell culture system, method for the production thereof and use in preclinical testing

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Embodiment Construction

[0026] In preferred embodiments, the tissue cells of the first compartment are adherent. Tissue cells preferably adhere to the surface of the separation layer. The separation layer can be precoated with a suitable substance. Substances can be, for example, proteins, especially extracellular matrix proteins. The separation layer may be coated with collagen, laminin, tenascin, etc., for example.

[0027] The tissue cells of the first compartment are advantageously pre-cultured on the surface of the separating layer. In particular the invention provides tissue cells to cover at least part, preferably the entire, compartment. Tissue cells may cover the separation layer, in particular in the form of a layer, preferably in the form of a monolayer.

[0028] In a particularly preferred embodiment, the immune cells are phagocytic immune cells, especially monocytes and / or macrophages. Monocytes and macrophages represent immunoregulatory switching centers in the immune system. They a...

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Abstract

The invention relates to a cell culture system, particularly for the preclinical testing of active ingredients, comprising a first and a second compartment. The active ingredients are in communication with each other via a separation layer that is permeable for cellularly secretable substances between the first and second compartments, wherein the first compartment comprises a syntopic culture with tissue cells and immune cells and the second compartment has a culture with blood cells. The invention further relates to a corresponding method and to a kit and uses for the preclinical testing of active ingredients.

Description

technical field [0001] The present invention relates to cell culture systems, methods for producing said systems, kits and uses for preclinical testing of active substances. Background technique [0002] Preclinical active substance screening or preclinical testing of active substances in clinical studies in humans is especially important for the medical validation of substances after they have successfully passed this preclinical testing phase before they are tested. In addition to determining the main medical effect of the substance being tested, a further advantage of preclinical testing is the evaluation of the side effects of the active substance in clinical studies as it develops its efficacy. [0003] Thus, for example, early identification of undesired side effects enables cost savings. In addition, the risks for clinical test patients can be significantly reduced by complex preclinical studies of the active substances. [0004] Particularly suitable preclinical re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/06
CPCC12M1/123G01N33/5064G01N33/5055C12M23/34C12M25/04C12M33/14
Inventor 曼弗雷德·施莫尔兹
Owner EDI实验和诊断免疫学有限公司
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