Cefixime compound and preparation method thereof

A technology for cefixime and compound, which is applied in the refining of cefixime compound and the refining field of antibiotic drugs, can solve the problems of low purity of cefixime, and achieve the effects of low cost, guaranteeing safety and improving quality

Inactive Publication Date: 2009-09-30
郑仙锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented process helps create more pure and higher yields than traditional methods like synthetic chemistry or enzymatic reactions are used at their best. It also simplifies manufacturing processes while maintaining good product qualities with fewer steps needed compared to older technologies such as chemical reaction techniques that require multiple steps (chemically) which can be expensive and time-consuming).

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the process of producing specific types of drugs called Ceftriptides (Ceftizidine), particularly those containing certain carbapenems such as imipodone and ampicillium sulfate.

Method used

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  • Cefixime compound and preparation method thereof
  • Cefixime compound and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Take 100g of cefixime crude product, dissolve it in 10% sodium bicarbonate solution, adjust the pH value to 7.8, and fully react until clarified to obtain cefixime sodium salt solution, add 5g of active carbon for adsorption for 30 minutes, filter for decarburization, and add 1mol of cefixime to the filtrate / L hydrochloric acid solution, adjust the pH value to 3.6, precipitate crystals, filter, wash with water, and dry under reduced pressure at 50°C to obtain 92.4g of cefixime refined product, with a yield of 92.4%, and a purity of 99.8% by HPLC.

Embodiment 2

[0018] Get cefixime crude product 100g and dissolve in 600ml methanol, add 10% potassium bicarbonate solution, adjust the pH value to 7.5, fully react to clarification, obtain cefixime potassium salt solution, add 6g active carbon adsorption for 20 minutes, filter decarburization, Add 5 mol / L formic acid solution to the filtrate, adjust the pH value to 3.4, precipitate crystals, filter, wash with water, and dry under reduced pressure at 40°C to obtain 92.8 g of cefixime refined product with a yield of 92.8% and a purity of 99.9% by HPLC.

Embodiment 3

[0020] Take 100 g of cefixime crude product, add 2 mol / L potassium hydroxide solution, adjust the pH value to 7.9, fully react until clarification, and obtain cefixime potassium salt solution, add 7 g of active carbon for adsorption for 20 minutes, filter for decarburization, and add 2 mol / L to the filtrate L of sulfuric acid solution, adjust the pH value to 3.7, precipitate crystals, filter, wash with water, and dry under reduced pressure at 45°C to obtain 93.6g of cefixime refined product with a yield of 93.6% and a purity of 99.7% by HPLC.

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Abstract

The invention relates to a cefixime compound and the preparation method thereof. In the preparation method of the cefixime compound, a cefixime crude product prepared by the prior art is processed to gain comparatively purer cefixime compound by the following procedures: aqueous alkali is added to raw materials of the cefixime crude product, or the cefixime crude product is dissolved in organic solvent and reacts with the added aqueous alkali, the pH value is adjusted, and the reaction continues until clarification to obtain cefixime saline solution; and the cefixime elaboration product can be obtained after the sequential operations of adding active carbon for adsorption and filtration, adding acid solution into filter liquor, adjusting the pH value, separating out crystals, filtrating, rinsing and drying.

Description

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Claims

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Application Information

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Owner 郑仙锋
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