Anthropogenic antivirulin glycosidoprotein neutralizing genetic engineering antibody RD9 and preparation and application thereof

A technology of genetically engineered antibodies and rabies virus, applied in antiviral immunoglobulin, genetic engineering, antiviral agents, etc., can solve problems such as difficult large-scale production, difficult antibodies, limited applications, etc., achieve efficient expression and overcome technical bottlenecks Effect
CN101550189BInactive Publication Date: 2011-10-19INST OF HYGIENE & ENVIRONMENTAL MEDICINE PLA ACAD OF MILITARY MEDICAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF HYGIENE & ENVIRONMENTAL MEDICINE PLA ACAD OF MILITARY MEDICAL
Publication Date
2011-10-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an anthropogenic antivirulin glycosidoprotein neutralizing genetic engineering antibody RD9 and a preparation and an application thereof. The antibody is VH-connecting peptide-VK of a three-structural single-stranded antibody comprising a variable region of heavy chain and a variable region of light chain by using 12 sequences of amino acid of the 1 (CH1) 5' end of a constant region of a heavy chain as the connecting peptide AKTTAPSVYPL, and the antibody realizes efficient expression in a prokaryotic system. The biological characteristic studies show that the RD9 is ananthropogenic genetic engineering antibody which has high appetency and better stability and can specially centralize rabies virus as well as genes and gene products of the antibody can be used for preparing clinical drugs for preventing and treating the rabies; the preparation method of the antibody is easy for massive industrial production. The invention solves the problem in the other technology of the application of genes of the variable region of the heavy chain and the variable region of a light chain of the antibody and polypeptide coded by the genes in the drugs for preventing and treating the rabies.
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Description

(1) Technical field:

[0001] The invention belongs to the field of biotechnology and relates to an anti-rabies virus antibody and its preparation and application, in particular to a human anti-rabies virus glycoprotein neutralizing genetic engineering antibody RD9 and its preparation and application. (2) Background technology:

[0002] Rabies is an infectious disease with the highest mortality rate, with a case fatality rate of 100%. Rabies is widely distributed around the world, and more than 60,000 people die from rabies every year. my country is also a country with a high incidence of rabies. At present, another peak of rabies epidemic is taking shape in our country! The prevention and treatment of rabies has become one of the most important public health problems in our country. It is almost impossible for humans to eliminate rabies from the earth, because rabies is a symbiotic disease of humans and animals, and humans still cannot control the occurrence of animal rabies. ...

Claims

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