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Method for the glucose concentration in pulsational blood

A technology of blood sugar concentration and measurement value, applied in the field of blood sugar measurement, can solve the problems of finding a standard calibration method, difficult and so on

Inactive Publication Date: 2009-10-14
NIRLUS ENG AG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The photoacoustic method is ultimately an empirical method to the greatest extent, and it is clearly difficult to find standard calibrations for broad applicability

Method used

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  • Method for the glucose concentration in pulsational blood
  • Method for the glucose concentration in pulsational blood

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Embodiment Construction

[0047] exist figure 1 , a side view of a measuring vessel (Messkuevette) is shown in the upper drawing area, in which two laser sources 10 and 14 and a temperature sensor 12 are arranged on one side (here facing the observer). The laser sources 10 and 14 are preferably exit ends of optical fibers, but may also be laser diodes powered on site. In the laboratory experiments shown below, a continuously tunable laser source of the high performance tunable laser TSL-510 SANTEC type was used, but this should not be a preferred embodiment of the invention for cost reasons. The incident power is preferably 10 mW in the devices described here.

[0048] A temperature sensor 12 measures the external temperature of the container. This external temperature can be used without difficulty by a calibration to derive the blood temperature. However, it should be noted that the measuring vessel with the temperature sensor 12 is very well shielded against temperature fluctuations. Otherwise, ...

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Abstract

Method for the continuous measurement of the glucose concentration in blood undergoing pulsational flow, with the steps: - determination of a value for the glucose concentration for a first measurement cycle, and - repetition of the determination of this value in subsequent measurement cycles, where there is multiple detection, within each measurement cycle, of the transmittance and / or scattering power of the blood for at least two incident NIR wavelengths, calculation of an indicator value depending on the blood glucose concentration, and ascertaining the blood glucose concentration by comparing the indicator value with a previously determined calibration table, determination of the blood temperature during the detection of the transmittance and / or scattering power, - continuous measurement of the pulse duration of the pulsational blood flow, where the duration of the measurement cycle is arranged to keep in step as integral multiple of the pulse duration, where the first of the at least two NIR wavelengths is selected from the wavelength range 1560-1630 nm, and the second of the at least two NIR wavelengths is selected from the wavelength range 790-815 nm, and the ratio of the transmittance and / or scattering power of the at least two wavelengths is calculated, this ratio serving in relation to the blood temperature as indicator value for reading off the blood glucose concentration from the calibration table.

Description

technical field [0001] The invention relates to a method for the contactless measurement of blood glucose by means of NIR (near infrared) spectrometry in flowing pulsating blood, wherein the flowing pulsating blood is in particular first extracted from a living organism and treated, for example, by dialysis It is then infused back into the organism. The invention also relates to a device which is suitable as an additional or integrated part of a dialysis device for monitoring blood glucose levels. The invention can furthermore be used for non-invasive monitoring of blood glucose levels in vivo. Background technique [0002] Determining the blood glucose level without direct contact with blood, in particular without drawing blood specifically for this purpose, has been the object of intensive medical research and development for more than two decades. Among other things, the main goal is to provide diabetics with a compact, portable measuring device which, ideally at most, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61M1/36
CPCA61M1/367A61B5/14557A61B5/1459A61B5/7207A61B5/14532A61M2230/201
Inventor V·赫尔曼
Owner NIRLUS ENG AG
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