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A system, method, computer-readable medium, and use for planning combined therapy

A computing unit and targeted therapy technology, applied in computer-aided planning/modeling, treatment, radiation therapy, etc., can solve the problems of patient discomfort, time-consuming treatment planning, etc., to reduce discomfort, increase flexibility and cost-effectiveness, Improve the effect of treatment

Inactive Publication Date: 2009-10-21
KONINKLIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

[0004] When treating a patient for neoplasia, physicians face the problem that if a patient requires multiple treatment regimens, it is time consuming to perform treatment planning for each of them
This can lead to longer periods of discomfort for the patient

Method used

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  • A system, method, computer-readable medium, and use for planning combined therapy
  • A system, method, computer-readable medium, and use for planning combined therapy
  • A system, method, computer-readable medium, and use for planning combined therapy

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Embodiment Construction

[0023] Embodiments of the present invention will be described in more detail below with reference to the accompanying drawings so that those skilled in the art can practice the invention. However, this invention can be implemented in many different ways and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will convey the scope of the invention to those skilled in the art. The embodiments do not limit the invention, but the invention is only limited by the appended claims. Furthermore, the terminology used in the detailed description of the particular embodiments shown in the drawings is not intended to limit the invention.

[0024] In some embodiments the invention provides methods of treatment planning for combination therapy with necrosis-inducing therapy and necrosis-targeting agents. Thus, the method focuses on the effect of one treatment on another, r...

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Abstract

A system and method for planning a necrosis-inducing therapy and subsequent administration of a necrosis-targeting agent are described. The system takes into account the effect of necrosis-induction therapy as a basis for the biodistribution estimate of the necrosis- targeting agent. This interaction between the different calculation steps is essential for an accurate planning result. A computer-readable medium and use are also provided.

Description

technical field [0001] The present invention relates generally to the field of treatment planning, and more particularly to combination therapy with necrosis-inducing therapy and necrosis-targeting agents. Background technique [0002] Local minimally invasive treatment options are an alternative to surgical resection in the treatment of locally confined neoplasia such as small tumors or cancerous metastases. Many of these methods, such as high-intensity focused ultrasound (HIFU), radiofrequency ablation (RFA), cryotherapy, laser ablation, and microwave ablation (MWA), are currently underdeveloped. In these methods, the tissue containing the cancerous lesion is superheated or supercooled, resulting in the uncontrolled death of up to 100% of cells in the treated area (coagulation necrosis). [0003] Necrotic cells exhibit leaky membranes compared to normal or apoptotic cells. This fact is currently being exploited in the clinical trial phase by a biomolecular targeting mech...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/14A61B18/18A61N7/00A61K51/10
CPCA61B18/1815A61N7/02A61B2017/00084A61B19/50A61B2019/5236A61N5/103A61B18/18A61K51/1045A61B34/10A61B2090/374
Inventor J·C·乔吉B·施维泽
Owner KONINKLIJKE PHILIPS NV
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