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Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases

A technology of heteroaryl and heterocyclic groups, applied in medical preparations containing active ingredients, organic chemistry, organic active ingredients, etc., can solve problems such as excessive activity and weakening

Inactive Publication Date: 2009-10-28
VERTEX PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Single-allelic knockout of GSK-3β results in attenuated hyperactivity as a response to amphetamine in a model of manic behavior

Method used

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  • Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases
  • Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases
  • Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases

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Abstract

The present invention relates to substituted pyridine or pyrimidine derivatives useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Description

[0001] Technical Field of the Invention [0001] The present invention relates to compounds useful as protein kinase inhibitors. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using these compositions to treat various disorders. The invention also provides methods of preparing the compounds of the invention. Background of the invention [0002] A serine / threonine protein kinase consisting of glycogen synthase kinase-3 (GSK-3) as alpha and beta isoforms each encoded by a different gene [Coghlan et al., Chemistry & Biology 2000, 7, 793-803; and Kim and Kimmel, Curr. Opinion Genetics Dev., 2000 10, 508-514]. GSK-3 is involved in various diseases, disorders and disorders including diabetes, Alzheimer's disease, CNS disorders such as bipolar disorder, schizophrenia, stroke, Huntington's disease and other neurodegenerative diseases, leukopenia and cardiomyocytes Hypertrophy [PCT Application Nos: WO 99 / ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D403/12C07D417/12C07D417/14C07D471/04A61K31/506
Inventor J·吉米奈茨P·克里尔A·米勒
Owner VERTEX PHARMA INC