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Ready-to-use Dactylicapnos scandens ophthalmic gel

A technology of Jinlongyan and Zijinlong, which is applied in the field of instant gel preparations for Zijin longan and ophthalmic instant gel preparations, can solve the problems of reducing drug action time, increasing drug action time, and lasting damage to eye tissues, etc., to achieve Good sustained-release characteristics, improved bioavailability, and good fluidity

Inactive Publication Date: 2009-11-18
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to tear dynamics, ophthalmic solutions have a very short residence time on the ocular surface, and the amount of drug absorbed is usually only a small part of the administered dose, even if the drug is on the surface of the eyeball, because of blinking and dilution of tears, the drug The effective concentration of the drug is reduced, and the action time of the drug is reduced, so the solution must be administered repeatedly to ensure the effective drug concentration, increase the action time of the drug, and achieve a higher drug absorption. This requires frequent eye drops, but frequent Drug administration can easily cause lasting damage to eye tissue, it is inconvenient to use, and it is difficult for patients to persist

Method used

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  • Ready-to-use Dactylicapnos scandens ophthalmic gel
  • Ready-to-use Dactylicapnos scandens ophthalmic gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Prescription: Zijinlong 2.5kg Gellan Gum 30g

[0048] Preparation method: Take Zijinlong medicinal material, coarsely pulverize it, use ethanol as a solvent, soak for 12 hours, and then percolate until the filtrate is light in color; take the filtrate and concentrate it to an appropriate amount, extract it three times with chloroform, combine the chloroform liquid, Evaporate to dryness, dissolve the residue, and set aside; add gellan gum, boric acid, and borax to 4000ml of water for injection, heat to boil, cool to 80°C, add Zijinlong extract, cool to 60°C while stirring, and add paraben B Dissolve 2.5g of the ester in ethanol, add dropwise to the above solution while stirring, add water for injection to 5000g, stir for more than 30 minutes, pass through a microporous membrane, and aseptically dispense to obtain the product.

Embodiment 2

[0050] Prescription: Zijinlong 1kg, gellan gum 14g, hydroxypropyl methylcellulose 2g

[0051] Preparation method: Take Zijinlong medicinal material, coarsely pulverize it, use ethanol as a solvent, soak for 12 hours, and then percolate until the filtrate is light in color; take the filtrate and concentrate it to an appropriate amount, extract it three times with chloroform, combine the chloroform liquid, Evaporate to dryness, dissolve the residue, and set aside; add gellan gum, boric acid, and borax to 1600 ml of water for injection, heat to boil, add ethylparaben, stir to dissolve, then add hypromellose, stir to dissolve, Add Zijinlong extract, mix well, add water for injection to 2000g, stir for more than 30 minutes, pass through a microporous membrane, and aseptically dispense to obtain the product.

Embodiment 3

[0053] Prescription: Zijinlong 1kg gellan gum 10g

[0054] Preparation method: Take Zijinlong medicinal material, coarsely crush it, extract twice with 80% ethanol under reflux, each time for 2 hours, filter, combine the filtrate, recover the ethanol under reduced pressure until there is no alcohol smell, filter, and set aside; take 1000ml of water for injection, Add gellan gum, stir evenly, put in a boiling water bath, stir until clear, add citric acid and glycerin, then add 0.5g of methylparaben and 0.5g of propylparaben, stir until clear, add the above Zijinlong extract, filter, add water for injection to 2000g, autoclave at 120°C for 20 minutes, let cool, and pack aseptically.

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Abstract

The invention discloses a ready-to-use Dactylicapnos scandens ophthalmic gel preparation, belonging to the field of traditional Chinese medicines. The active ingredient of the preparation is from Dactylicapnos scandens which is Chinese medical herbs and the gel base material of the preparation mainly comprises gellan gum accounting for 0.4-0.7 percent of the total weight. The technical scheme overcomes the deficiencies that the prior Dactylicapnos scandens ophthalmic preparation has low bioavailability, inconvenient use, short retention time, and the like and has the effects of reducing dose, prolonging the retention time in eyes, having convenient use and accurate dose, and the like.

Description

technical field [0001] The invention relates to an instant gel preparation for Zijin longan, in particular to an instant gel preparation for ophthalmology with gellan gum as the main gel base material, belonging to the field of traditional Chinese medicine. Background technique [0002] Zijinlong is the dried root of Dactylapnos scandens (D.Don) Hutchins., a plant of the family Papaveraceae. It is mainly distributed in western Yunnan. Pharmacology has confirmed that alkaloids are the main active ingredients for analgesia and hemostasis. Zijinlong has been used in ophthalmic preparations. Myopia Eye Drops is developed with Zijinlong as the main drug. It is mainly used to treat myopia, pseudomyopia and visual fatigue in young people. Myopia eye drops have been included in the standard issued by the national ministry (standard number WS3-B-3851-98). [0003] As a traditional dosage form, Myopia Eye Drops has the advantages of convenient use, good compliance, and low price. Ho...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61K9/00A61K47/36A61K47/38A61K47/40A61K47/34A61K47/32A61P27/10A61K125/00A61K47/10A61K47/26
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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