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Systems for effecting cessation of tobacco use

A tobacco and nicotine-free technology, applied in the directions of medical preparations, pharmaceutical formulations, organic active ingredients, etc. containing active ingredients, can solve the problems of nicotine smoking cessation, user weanoff, low success rate, etc., and reduce addiction. On its own, the effect of eliminating nicotine cravings

Inactive Publication Date: 2009-11-18
ARADIGM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some believe that the success rate of these conventional treatments is not high due to the complete lack of "high" experienced by patients
[0009] Therefore, there remains a need for smoking cessation therapies that deliver precise doses of nicotine directly to the lungs and thus directly into the arterial circulation in a pattern that mimics the blood levels achieved by smoking - providing an initial surge in blood levels that makes it possible for the user to wean (wean off) nicotine and quit smoking

Method used

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  • Systems for effecting cessation of tobacco use
  • Systems for effecting cessation of tobacco use
  • Systems for effecting cessation of tobacco use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0179] Example 1: Single Dose Administration of Nicotine Formulations for Deep Lung Delivery

[0180] Smoking dependence appears to be related in part to the "high and fast" rise in nicotine plasma concentrations achieved by cigarettes, cigars and pipes. However, unlike cigarettes, current nicotine replacement therapy (NRT) achieves relatively "low and slow" plasma nicotine concentrations ( figure 1 ). This example demonstrates a nicotine delivery system that provides cigarette-like plasma levels sufficient to reduce craving, inhibit relapse, and produce higher rates of smoking cessation compared to existing NRTs.

[0181] The AERx Essence System known in the art was used to deliver a bolus of aerosolized nicotine to healthy adult male smokers. The AERx Essence system is a fully mechanical, propellant-free, hand-held device in individually packaged single-use dosage strips. A uniform and fine breathable aerosol is produced when the drug solution is "squeezed" through a seri...

Embodiment 2

[0196] Example 2: Use of Alternative Nicotine Forms

[0197] This example demonstrates the effectiveness of different nicotine dosage forms of the present invention. The purpose of this example is to illustrate that generally available nicotine formulations are suitable for use in the present invention.

[0198] Formulation studies were conducted to evaluate the effect of nicotine salts and pH on The effectiveness of the stability of nicotine in dosage forms. Nicotine is a weak base (pka 1 = 3.4 and pKa 2 = 8.4) and in a non-ionized state can be absorbed into polymeric materials used in many nicotine delivery systems. When screening studies were conducted using buffered nicotine sulfate and bithalate in the pH range of 3.0-7.0, at the lower pH of 3.0 and 4.0, nicotine concentrations were practically unchanged for both salts. Change. In this pH range, nicotine bisalate is better than nicotine sulphate in ensuring that nicotine is not lost into the polymeric dosage form m...

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PUM

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Abstract

This invention relates generally to formulations, compositions, aerosols and kits used to provide habitual tobacco users with products, methods and apparatus to reduce and eventually terminate their dependence on nicotine containing products. More specifically, the invention relates to a nicotine-based medicament and dosage forms thereof formulated in such a way as to effectively reduce or eliminate the sensations of craving associated with addictive nicotine use.

Description

[0001] government power [0002] This invention was made with Government support and was made under Federal Grant No. 1R43DA019301-01 (June 15, 2005 to June 15, 2006) awarded by NIDA. The US Government has certain rights in this invention. technical field [0003] The present invention relates generally to systems and kits for treating conditions responsive to nicotine therapy. More specifically, the present invention relates to systems for use in the pulmonary administration of nicotine-containing formulations to achieve nicotine addiction associated with the use of tobacco products. Background technique [0004] Diseases related to smoking and other forms of tobacco consumption, such as lung disease, heart disease and cancer, claim 400,000 lives each year. Combustion of tobacco produces toxicants and carcinogens that pose significant health hazards to both smokers and non-smokers. Nicotine is the main constituent of tobacco and has the greatest pharmacological activity....

Claims

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Application Information

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IPC IPC(8): A61K31/137
Inventor 艾格·贡达
Owner ARADIGM
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