Acebrophylline and composition thereof
The technology of a composition and vinegar tea is applied in the directions of drug combination, active ingredients of heterocyclic compounds, respiratory system diseases, etc., and can solve the problems of poor stability, long crystallization time, crystallization water or crystallization solvent, etc.
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Embodiment 1
[0046]In a 2000ml reaction flask equipped with stirring, thermometer, and condenser, add 100g of bromoxol and 350ml of N.N-dimethylformamide (DMF), start stirring, heat up to 45±2°C, and completely dissolve. Adjust the stirring speed to 40-50 revolutions per minute, then add 35ml of acetone and 840ml of ethyl acetate, stir and lower the temperature to 15±2°C, and keep stirring for 1.2 hours. Crystals were precipitated, filtered, washed with 30 ml of ethyl acetate, placed in a solid chamber for 2 hours, then moved to a vacuum oven, and vacuum-dried (0.05-0.06 Mpa) for 6 hours to obtain 96 grams of crystalline powder.
[0047] The X-ray diffraction pattern of this crystalline powder is shown in figure 1 . Instrument model and measurement conditions: Rigaku D / max2500 diffractometer; CuKa 40Kv 100mA; 2θ scanning range: 0-50°;
[0048] The infrared spectrogram of this crystalline powder is shown in figure 2 , Determination with KBr tablet.
[0049] The high performance liquid ...
Embodiment 2
[0052] Granules containing broxolin crystal form of vinegar tea
[0053] Prescription: 100 grams of new crystal bromoxol, 600 grams of microcrystalline cellulose, 300 grams of lactose, 75 grams of crospovidone, 100 grams of PEG-6000, 105 grams of hydroxypropyl methylcellulose, appropriate amount of distilled water , made into 1000 bags.
[0054] Process: PEG-6000 and new crystal bromoxol are pulverized together, passed through an 80-mesh sieve, mixed with other materials, made into soft materials with distilled water, granulated, dried at low temperature, and then packed into granules.
Embodiment 3
[0056] Capsules containing broxolin crystalline form of vinegar tea
[0057] Prescription: 100 grams of new crystal form of bromoxol vinegar, 1.5 ml of propylene glycol, 70 grams of starch, made into 1000 capsules.
[0058] Process: Moisten the new crystal form of bromoxol and starch with 15% propylene glycol aqueous solution, mix well, sieve and granulate, dry at 60°C, granulate, and fill capsules.
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