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Measuring agglutination parameters

A parametric, particle-based technology for the quantitative measurement of one or more agglutination parameters of magnetic markers, resulting in ease of use, improved sensitivity, and simplified manufacturing

Active Publication Date: 2010-01-13
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] Although many techniques exist for measuring coagulation parameters, there is still a need for more efficient and / or more reliable and / or more sensitive methods
For example, measuring low numbers of clumped species in a background of many non-clustered species, and / or measuring low numbers of non-clustered species in a background of many clumped species in agglutination assays are challenging

Method used

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Embodiment Construction

[0062] The present invention will be described with respect to certain embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. Any reference signs in the claims should not be construed as limiting the scope. The drawings described are only schematic and not limiting. In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for purpose.

[0063] When the term "comprising (comprising, containing)" is used in the description and claims of the present application, it does not exclude other elements or steps. When a definite or indefinite article is used when referring to a singular noun such as "a", "an" or "the", this includes a plurality of that noun unless otherwise stated.

[0064]Further, the terms first, second, third, etc. in the specification and claims of this application are used to distinguish similar elements, and not necessarily used to describe time, space, sequence or an...

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Abstract

A method and system are described for measuring agglutination in a target- induced agglutination assay with one or more magnetic particles performed in a reaction chamber. After the magnetic particles (3, 15), which are capable of binding to a target (5) are provided in the assay, an agglutination process resulting in agglutinated particles (100) comprising at least one magnetic particle is performed. The method then further comprises applying an alternating current magnetic field (HAC) to the assay and- measuring an effect of the HAC on the one or more magnetic particles (3,15) unattached to any surface. The measured effect is indicative of one or more agglutination parameters.

Description

technical field [0001] The present invention relates to the field of biological, chemical or biochemical sensing. In particular, the present invention relates to a method for the quantitative measurement of one or more agglutination parameters of magnetic labels in a target-induced agglutination assay. The invention also relates to a corresponding kit and a corresponding device. Background technique [0002] In recent years, much effort has been devoted to measurement techniques for measuring the presence or absence and possibly concentration levels of target substances in large mixtures or solutions in which particles are present. It is often desirable to be able to measure relatively low concentrations of specific organic compounds. In the field of medicine, for example, it is very useful to determine the concentration (usually in solution) of a given kind of molecule, either naturally present in a physiological fluid such as blood or urine, or introduced into a living s...

Claims

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Application Information

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IPC IPC(8): G01N15/02G01N33/543G01R33/12
CPCG01R33/12G01R33/1269G01N27/745G01N33/54326G01N15/0266
Inventor W·U·迪特默P·德基维特J·H·纽文休斯M·W·J·普林斯L·J·范伊曾多尔恩X·J·A·詹森
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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