Preparation method of concentrated type heat-clearing and detoxicating oral liquid

A technology for clearing away heat and detoxifying and taking oral liquid, which is applied in the directions of medical preparations, antiviral agents, and pharmaceutical formulations containing active ingredients, which can solve the problems of poor production safety, large amount of ethanol, and high energy consumption, and can ensure product quality and safety. The effect of stability, shortening production cycle and improving production efficiency

Inactive Publication Date: 2011-05-04
HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process adopts the traditional water decoction and alcohol precipitation preparation method, the traditional water decoction extraction method, the active ingredients of the medicinal materials are not completely extracted, the impurity content is high, the utilization rate of the medicinal materials is low, and the energy consumption is large; large, poor production safety, long production cycle, and high cost; the conventional circulating steam sterilization method, the sterilization time is 20-35 minutes, can destroy most of the active ingredient chlorogenic acid of honeysuckle due to the long heating time, making it content reduction
In a word, the concentration of oral liquid produced by this method is low, and the content of active ingredients is low, so that the dosage is increased each time, which is inconvenient to take and carry.
[0004] The preparation method of the concentrated heat-clearing and detoxifying oral liquid of Chinese Patent Authorization Announcement No. CN100506261C adopts hollow fiber membrane material to filter in the final filtration process of the preparation method of Qingrejiedu oral liquid in "Chinese Pharmacopoeia" 2005 edition one. The process operation is cumbersome, especially the filtration speed of the concentrated heat-clearing and detoxifying oral liquid containing too many medicinal materials is slow, time-consuming and low in production efficiency
But it still exists (1) the extraction of medicinal materials is not complete, and the content of active ingredients is low; (2) it is feasible for ordinary Qingrejiedu oral liquid containing relatively small amount of medicinal materials, and it is feasible for Qingrejiedu oral liquid containing twice the amount of medicinal materials as the ordinary type (Concentrated type) is not feasible, because the liquid medicine after the final preparation is relatively thick, and it is difficult to filter by ultrafiltration, and the filtration speed is slow.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (a) By weight percentage: gypsum 42.83%, Scrophulariaceae 7.90%, Rehmannia glutinosa 6.10%, Forsythia 4.29%, Gardenia 4.29%, Sweet Diding 4.29%, Gentian 4.29%, Banlangen 4.29%, Anemarrhena 3.45% , Ophiopogon japonicus 3.45%, add the water of 10 times of amount of the sum of above-mentioned drug raw material weight, after heating to be boiled, stop heating, add honeysuckle 9.82%, Scutellaria baicalensis 5.00% after temperature is down to below boiling point, ultrasonic extraction (frequency 25KHz, Power 20kW) two times, 20min each time, filter, combine the filtrate, concentrate the filtrate under reduced pressure to a relative density of 1.05-1.10 (measured at 60°C), and obtain the extract concentrate.

[0029] (b) extract the concentrated solution obtained in step a, add chitosan flocculation clarifying agent with a concentration of 0.1% under the condition of 60 ° C, so that the chitosan content in the liquid reaches 0.10%, stir for 20 minutes, place for 24 hours, and t...

Embodiment 2

[0032] (a) By weight percentage: gypsum 44.64%, Scrophulariaceae 7.13%, Rehmannia glutinosa 5.33%, Forsythia 4.46%, Gardenia 4.46%, Sweet Diding 4.46%, Gentian 4.46%, Banlangen 4.46%, Anemarrhena 3.60% , Ophiopogon japonicus 3.60%, add the water of 12 times of amount of the sum of above-mentioned drug raw materials weight, after heating, after boiling, stop heating, add honeysuckle 8.93%, Scutellaria baicalensis 4.47% after temperature is down to below boiling point, ultrasonic extraction (frequency 40KHz, Power 15kW) two times, each time for 30min, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to about 1:1 of the sum of the weight of the medicinal solution and the weight percentage of each raw material to obtain the extraction concentrate.

[0033] (b) Add 0.1% chitosan flocculation clarifier to the extract concentrate at 55°C to make the liquid contain chitosan up to 0.11%, stir for 20 minutes, place for 24 hours, take the supernatant and f...

Embodiment 3

[0036](a) Taken by weight percentage: gypsum 45.10%, Scrophulariaceae 6.00%, Rehmannia glutinosa 6.50%, Forsythia 4.60%, Gardenia 4.60%, Sweet Diding 4.60%, Gentian 4.60%, Banlangen 4.60%, Anemarrhena 3.70% , Ophiopogon japonicus 3.70%, add the water of 14 times of amount of the sum of above-mentioned drug raw materials weight, after heating to be boiled, stop heating, add honeysuckle 8.00%, Scutellaria baicalensis 4.00% after temperature is down to below boiling point, ultrasonic extraction (frequency 75KHz, power 17kW) twice, each time for 40min, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.05-1.10 (measured at 60°C), or concentrate to the sum of the weight of the medicinal solution and the weight percentage of each raw material About 1:1, the extraction concentrate is obtained, and the extraction concentrate is obtained.

[0037] (b) Add 0.1% chitosan flocculation clarifier to the extract concentrate at 70°C to...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of concentrated type heat-clearing and detoxicating oral liquid. The preparation contains twelve medicinal materials of gypsum, honeysuckle, figwort, rehmannia root, weeping forsythia, gardenia, herba gueldenstaedtiae, baikal skullcap root, rough gentian, radix isatidis, rhizoma anemarrhenae and ophiopogon root. When being prepared, an ultrasonic extraction method, a chitosan flocculation method for impurity removal and a microwave sterilization technology are adopted, so that the effective components of the medicinal materials are extracted completely, the medicine concentration is increased, and the content of the effective components is enhanced; the production efficiency is enhanced, and the production cost is lowered. As the effective concentration in the unit volume of the medicine in the invention is doubled, the oral dosage of the medicine is correspondingly reduced, taking and carrying can be more convenient, wrapping materials are saved, and the invention is beneficial to environmental protection.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of concentrated heat-clearing and detoxifying oral liquid. Background technique [0002] Qingrejiedu Oral Liquid is a traditional Chinese medicine oral liquid preparation extracted and refined from gypsum, honeysuckle, scrophulariaceae, rehmannia, forsythia, gardenia, candiding, scutellaria baicalensis, gentian, isatis root, Anemarrhena anemarrhena, and Ophiopogon japonicus. , has the function of clearing heat and detoxifying. It is used for fever, flushed face, irritability and thirst, and sore throat caused by excessive heat and toxin; flu and upper respiratory tract infection see the above syndromes. The clinical application is wide, the curative effect is good, and there is no toxic or side effect, and it is welcomed by the majority of patients. [0003] The preparation method of Qingrejiedu oral liquid recorded...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K36/8968A61K9/08A61P11/04A61P31/16A61K33/06
Inventor张立壮郭中华张志平
OwnerHENAN TALOPH PHARMACEUTICAL STOCK CO LTD