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Method for producing CdTe-tamoxifen fluorescent probe

A tamoxifen and probe technology, applied in the field of fluorescent probe preparation, to achieve the effects of easy control of composition, low cost, and good fluorescence characteristics

Inactive Publication Date: 2010-01-27
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research is mainly focused on biomarkers, and quantum dot fluorescent probes with dual functions (labeling and treatment) have not been reported yet.

Method used

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  • Method for producing CdTe-tamoxifen fluorescent probe
  • Method for producing CdTe-tamoxifen fluorescent probe

Examples

Experimental program
Comparison scheme
Effect test

Synthetic example 1

[0018] Dissolve 0.0018g of tamoxifen in 10mL of secondary water, add 10mL of NaHTe to reduce CdCl 2 The pH of the CdTe solution prepared and purified by isopropanol was adjusted to be neutral. Under the protection of nitrogen, the reaction system was heated to 40° C., condensed and refluxed for 60 min to obtain the CdTe-CdTe-tamoxifen fluorescent probe.

Synthetic example 2

[0020] Take 0.0141 g of tamoxifen and dissolve it in 20 mL of secondary water, add 10 mL of the CdTe solution prepared according to the method of Example 1 above, and adjust the pH to be neutral. Under the protection of nitrogen, the reaction system was heated to 100° C., condensed and refluxed for 180 min to obtain the CdTe-tamoxifen fluorescent probe.

Synthetic example 3

[0022] Take 0.0141 g of tamoxifen and dissolve it in 15 mL of secondary water, add 10 mL of the CdTe solution prepared according to the method of Example 1 above, and adjust the pH to be neutral. Under the protection of nitrogen, the reaction system was heated to 60° C., condensed and refluxed for 100 min to obtain the CdTe-tamoxifen fluorescent probe.

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Abstract

The invention belongs to the technical field of a semiconductor and a biomarker, particularly relates to a method for producing a fluorescent probe. The invention adopts the surface modification technology, mixes tamoxifen and purified green CdTe solution, regulates the pH value of the system, and heats, condenses and reflows to produce a CdTe-tamoxifen probe. The probe has very strong fluorescence under the ultraviolet radiation and has excellent fluorescent characteristic by the spectral analysis. Researches show that CdTe-tamoxifen has strong interaction with polypeptide and is already used in the marking of carcinoma cells successfully. The invention has the advantages that the material synthesis method is simple, the cost is easy to control, the cost is relatively low, and the quantum dot probe obtained has excellent fluorescent characteristic.

Description

technical field [0001] The invention belongs to the technical field of semiconductors and biomarkers, and in particular relates to a preparation method of a fluorescent probe. Background technique [0002] Due to the particularity and complexity of biological systems, in order to detect more biologically active substances, there are high requirements for laser-excited bioluminescent probes. At present, the most commonly used fluorescent probes are organic dyes, but their excitation spectra are narrow, so it is difficult to excite multiple components at the same time; and their fluorescence emission spectra are wide, and the distribution is asymmetric, so it is necessary to simultaneously Detection of multiple components is difficult. The most serious defect of organic dyes is poor photochemical stability. Photobleaching and photolysis make it impossible for each dye probe to emit too many fluorescent photons on average, and photolysis products often have a killing effect on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64G01N33/533G01N33/574
Inventor 尚庆坤冯雪娇刘俊余单桂晔张维静刘红剑
Owner NORTHEAST NORMAL UNIVERSITY
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