Composition for slimming

A composition and substance technology, applied in the directions of drug combinations, active ingredients of heterocyclic compounds, metabolic diseases, etc., can solve the problems of not completely solving the problem of obesity, side effects, difficulty in guaranteeing efficacy and safety, etc., to prevent the re-accumulation of fat, The effect of suppressing the increase in volume and number, and suppressing the accumulation of fat

Inactive Publication Date: 2010-04-07
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since these methods cannot completely solve the obesity problem and have severe side effects, the efficacy and safety are still difficult to guarantee
In addition, for the sake of beauty, the treatment of obesity should not only remove fat, but also pay attention to improving the condition of the skin, so the above methods are still insufficient

Method used

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  • Composition for slimming
  • Composition for slimming
  • Composition for slimming

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0044] Preparation Example 1 Extraction of catechins

[0045] 2 kg of green tea leaves were soaked in 10 liters of water at 80° C. for 5 hours to obtain an extract and the resulting solution was collected. In addition, the filter residue was soaked in 5 liters of 80° C. water for 3 hours to obtain a solution again, and the two solutions were mixed. The solution was filtered through filter paper and treated with ethyl acetate to obtain an ethyl acetate extract, which was then treated with chloroform to remove caffeine and then concentrated. The obtained solution was passed through an agarose gel column, and rinsed with a mixture of dichloromethane and methanol (1:1), and then the rinse solution was concentrated at 40° C. to obtain catechin powder.

[0046] Reference Example 1 Separation of Adipocytes (Adipocytes)

[0047] Cut the epididymis fat tissue isolated from male SD rats into small pieces, add 0.1% by weight collagenase (in DMEM culture medium without adding phenol red...

Embodiment 2

[0049] Reference Example 2 Differentiation of Adipocytes (Adipocytes)

[0050] Rat fibroblast cell line 3T3-L1 cells were treated with 1×10 5 Cells / well were seeded into 6-well culture plates and cultured in Dulbecco's Modified Eagle's Medium (DMEM, GIBCO BRL, Life Technologies) containing 10% fetal bovine serum (FBS). After culturing for two days, the medium was replaced with new DMEM (containing 10% FBS), and cultured for another two days. The cultured cells were then placed in new DMEM (containing 10% by weight FBS) containing 1 μg / ml insulin, 0.5 mmol / L IBMX and 0.25 μmol / L dexamethasone (dexamethasone) to induce differentiation. Two days later, the The medium was replaced with new DMEM containing insulin and cultured for 5 days. After culturing for 5 days, the medium was changed to normal DMEM (containing 10% FBS) and observed until the cells became adipocytes (adipocytes).

[0051] The assay method of reference embodiment 3 lipolysis

[0052] The degree of fat breakd...

experiment Embodiment 1

[0053] Experimental Example 1 Efficacy of Theanine in Promoting Lipolysis

[0054] In order to measure the effect of theanine on promoting neutral lipolysis of adipocytes, 3T3-L1 adipocytes differentiated in Reference Example 2 were used.

[0055] The 3T3-L1 adipocytes were washed twice with phosphate-buffered saline (PBS), and then DMEM containing 0.5% by weight of bovine serum albumin (BAS) and containing no fatty acid was added thereto. Theanine (greater than 97%) was purchased from KuridaKogyo (Japan), GPO-trinder kit purchased from Sigma (St.Louis, MO, U.S.A.), glycerol was quantitatively determined by chromogenic reaction method, and enzyme-linked immunoassay The absorbance value at 540 nm was measured by an ELISA reader. The control was incubated in the absence of the test substance or the comparison substance, and then the data of the control was set as 100% to calculate the results for each component. In addition, a sample treated with the same concentration of caff...

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Abstract

The present invention relates to a composition for slimming, more particularly, to a slimming composition containing theanine and at least one selected from the group consisting of caffeine, genistein, L-carnitine and catechin. The composition of the present invention contains theanine and each of caffeine, genistein, L-carnitine, catechin or mixtures thereof, and has properties of decomposing fats, hydrolyzing lipid and removing cellulites.

Description

[0001] related application [0002] This application is a divisional application of the Chinese invention patent application whose application number is 200480010726.8, the application date is April 23, 2004, and the invention name is "weight loss composition". technical field [0003] The present invention relates to a weight loss composition, more particularly to a composition containing theanine and a composition selected from the group consisting of caffeine, genistein, L-carnitine and catechin. Slimming composition of at least one substance from the group. The composition of the invention contains theanine and one or more of caffeine, genistein, L-carnitine and catechin, and has the properties of decomposing fat, hydrolyzing lipid and removing cellulite. Background technique [0004] The human body has approximately 20000000000 fat cells that store and release energy in the body. The storage and release of energy in the body has a complex mechanism. When the supply of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/198A61K31/522A61K31/353A61K31/205A61P3/04A61K31/195
CPCA61K31/195A61P3/04A61P17/00A61P43/00
Inventor 金知贤安秀美李钟澯金英京李炳坤金宣姈朴智银朴贤宇李尚骏姜鹤熙
Owner AMOREPACIFIC CORP
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