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Traditional Chinese medicine compound preparation for preventing recurrent aphthae, preparation method and application thereof

A technology for recurrent aphthous ulcers and compound preparations, applied in the directions of pharmaceutical formulas, medical preparations containing active ingredients, and drug combinations, can solve the problems of unsatisfactory efficacy and low proportion of systemic treatment drugs, and achieve good development prospects and take Convenience and rich medicinal effects

Inactive Publication Date: 2011-05-25
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of systemic therapeutic drugs is not satisfactory, and the proportion of patients who control recurrence for more than half a year after medication is not high, such as commonly used immune drugs, generally around 40-50%

Method used

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  • Traditional Chinese medicine compound preparation for preventing recurrent aphthae, preparation method and application thereof
  • Traditional Chinese medicine compound preparation for preventing recurrent aphthae, preparation method and application thereof
  • Traditional Chinese medicine compound preparation for preventing recurrent aphthae, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation method of oral liquid for preventing and treating recurrent aphtha

[0026] Cortex paeonol 2Kg, add 20L water, soak 30min, steam distillation extracts distillate 8.0 hours, gained distillate after standing still at low temperature for 24 hours, decompression suction filtration obtains crystallization 0.55Kg and suction filtrate, suction filtrate low temperature decompression (- 0.085Mpa, 70 ~ 80 ℃) concentrated to obtain the water extract I; the obtained crystals were dried in a desiccator, weighed, and dehydrated alcohol was added to disperse the crystals according to 1:6 (crystallization amount: dehydrated alcohol), and dehydrated alcohol was obtained. Solution, use saturated aqueous solution method to include 10 times the amount of β-cyclodextrin, stir continuously at 45°C for 1.5 hours at a constant temperature of 100 rpm, refrigerate at 0-5°C for 24 hours, crystallize, and filter with suction , a small amount of purified water and ethy...

Embodiment 2

[0027] Embodiment 2: Prevention and treatment of recurrent aphtha drug effect test result

[0028] 1. Effects of prevention and treatment of recurrent aphth on the pathological morphology and immune organ index of oral ulcers in golden hamsters induced by carbolic acid

[0029] 120 golden hamsters were randomly divided into 6 groups, 20 in each group (16 in the blank control group). Except for the blank control group, animals in each group were given corresponding therapeutic drugs 36 hours and 12 hours before challenge.

[0030]When attacking the virus, anesthetize the golden hamster with ether, gently pull out the right cheek pouch with two hemostatic forceps, fix it, and use a glass tube with a length of 6 cm and an inner diameter of 0.8 cm, and a small cotton ball inside to make the small cotton ball Make the bottom even with the lower opening of the glass tube, then drop 90% carbolic acid solution into the tube until the small cotton balls are just soaked, and then place...

Embodiment 3

[0081] (3) Embodiment three: the acute toxicity test of oral liquid for prevention and treatment of recurrent aphthous sores——measurement of maximum dosage (MTD)

[0082] Take 40 Kunming mice, weighing 18-22 g, half male and half male. Randomly divided into 2 groups, 20 in each group. Namely (1) Kouchuang oral liquid group; (2) Blank control group. After 12 hours of fasting before the experiment, the oral solution for preventing and treating recurrent aphthous sores was given to the mice once by intragastric administration of 40ml / kg; the blank control group was given the same amount of normal saline. The behavior, activity, food intake, body weight, feces, and death of the tested mice were recorded for 2 weeks, and the undead mice were sacrificed 2 weeks later for autopsy.

[0083] Press 256g / kg [6.4g (crude drug) / ml * 40ml / kg] dose once gavage administration to 20 mice, on the same day and within 2 weeks after administration, see that the mouse hair color is smooth, activi...

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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine compound preparation used for preventing recurrent aphthae and application thereof, wherein the traditional Chinese medicine compound preparation is prepared by using Chinese medicines as raw materials. The preparation comprises the following Chinese medicinal herbs in parts by weight: 1-3 parts of rhizome coptisdis, 8-10 parts of capejasmine, 8-10 parts of cortex moutan, 8-10 parts of radix ophiopogonis, 4-6 parts of rhizome cimicifugae, 12-15 parts of rhizome phragmitis and 8-10 parts of raw cattail pollen. The preparation used for preventing recurrent aphthae can be used for treating mouth mucosa diseases, such as oral erosive lichen planus (OLP), chronic glossitis, glossopyrosis syndrome, behcet's diseases and chronic gingivitis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound Chinese medicine preparation for treating recurrent aphthous ulcers made from traditional Chinese medicines and a preparation method thereof. Background technique [0002] Recurrent aphthous ulcers (ROU for short) refer to localized ulcerative lesions of the oral mucosa with periodic paroxysmal characteristics. The incidence rate is high, and the prevalence rate of the general population is not less than 10%. Although the general condition is not significantly affected, it often recurs after a certain interval, once every few days, or even one after another without an interval, which hinders eating and speaking, and the patient is extremely painful. As the course of the disease prolongs, the area and number of ulcers can increase and increase, and the healing time will also tend to prolong. [0003] The etiology of this disease is complex, no con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P1/02
Inventor 过伟峰朱华旭卞慧敏李璘袁园
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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