Solid lipid nano-avermectin and preparation method and application thereof

A technology of solid lipid nanometer and abamectin, applied in the directions of botanical equipment and method, application, insecticide, etc., can solve the problems of decomposition of active ingredient abamectin, prolonging the validity period of medicine effect, complicated preparation process and the like , to achieve the effect of prolonging the efficacy period, prolonging the drug duration, and simple process.

Active Publication Date: 2013-08-21
SHENZHEN NOPOSION AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the preparation of the above composition has the serious decomposition of the active ingredient abamectin in the cold and hot storage experiments, and it is easy to photolyze during use, and the drug effect declines.
[0005] The patent application with publication number CN1663379A discloses the method for preparing abamectin microcapsules by in-situ polymerization, although the abamectin is not easily damaged or lost by the atmosphere, sunlight and rain, and the effective period of drug effect is extended, the preparation process is complicated. and can only be used to prepare suspension
[0006] At present, there is no report on the preparation of solid lipid nano-abamectin and its application in pesticide preparations at home and abroad.

Method used

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  • Solid lipid nano-avermectin and preparation method and application thereof
  • Solid lipid nano-avermectin and preparation method and application thereof
  • Solid lipid nano-avermectin and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 4% contains solid lipid nano-abamectin mother powder

[0028] The content of Abamectin is 40 g / kg

[0029] Capric acid content is 785 g / kg

[0030] Polyvinyl alcohol content of 165 g / kg

[0031] 41.5 grams of 97% Abamectin former drug and 785 grams of capric acid are dissolved in 100 grams of acetone, then mixed with 2200 grams of 7.5% polyvinyl alcohol aqueous solution, and the mixed solution is mixed evenly by stirring or shaking or high shearing. Emulsified, then ultrasonically micronized to make it 100-500 nanometer particles, stirred for 2 hours, and finally freeze-dried to obtain solid lipid nano-type abamectin mother powder.

Embodiment 2

[0033] 8% solid lipid nano abamectin mother powder

[0034] The content of Abamectin is 80 g / kg

[0035] Capric acid content is 760 g / kg

[0036] Polyvinyl alcohol content of 160 g / kg

[0037] 82.5 grams of 97% Abamectin former medicine and 760 grams of capric acid are dissolved in 200 grams of acetone, then mixed with 2000 grams of 8% polyvinyl alcohol aqueous solution, and the mixed solution is mixed evenly by stirring or shaking or high shearing to It is emulsified, then micronized by ultrasonic waves to make it into 100-500 nanometer particles, stirred for 3.5 hours, and then freeze-dried.

Embodiment 3

[0039] 12% solid lipid nano abamectin mother powder

[0040] The content of Abamectin is 120 g / kg

[0041] The content of capric acid is 700 g / kg

[0042] Polyvinyl alcohol content of 180 g / kg

[0043] 124 grams of 97% Abamectin former medicine and 700 grams of capric acid are dissolved in 300 grams of acetone, then mixed with 2000 grams of 9% polyvinyl alcohol aqueous solution, the mixed solution is mixed evenly by stirring or shaking or high shearing to It is emulsified, then micronized by ultrasonic waves to make it into particles of 100-500 nanometers, stirred for 5 hours, and then freeze-dried.

[0044] 2. The preparation method of the compound composition and its thermal and cold storage decomposition, ultraviolet light photolysis, bioassay experiment

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Abstract

The invention is applicable to the technical field of pesticide preparations and provides a novel solid lipid nano-avermectin and a preparation method and an application thereof. Compared with the composite preparation prepared by directly adopting avermectin raw medicine as a raw material, the solid lipid nano-avermectin improves the chemical stability of cold and hot storage, reduces the photolysis rate, prolongs the medicine effective period, reduces the dosage and significantly improves the insect-killing effect.

Description

technical field [0001] The invention belongs to the technical field of pesticide preparations, and in particular relates to a novel solid lipid nano-abamectin, a preparation method thereof and an application in pesticide preparations. Background technique [0002] Abamectin is a macrolide disaccharide compound, which is a biopesticide isolated from soil microorganisms. It has a strong penetrating effect on the leaves, kills pests under the epidermis, and has a long-lasting effect. Its mechanism of action is different from that of chemical pesticides in that it interferes with neurophysiological activity and stimulates the release of GABA. Therefore, abamectin is widely used in compounding with chemical insecticides and acaricides to expand the insecticidal spectrum, improve drug efficacy and reduce costs. [0003] For example: Chinese invention patent application "a synergistic insecticidal composition containing lufenuron and abamectin or emamectin benzoate and its applic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/04A01N43/90A01N25/12A01N25/14A01N47/34A01N43/12A01N47/38A01N43/707A01N51/00A01N43/56A01N43/22A01P7/04A01P7/02
Inventor 袁伏中曹明章李琛王新军张华东孔建
Owner SHENZHEN NOPOSION AGROCHEM
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