Oral antiviral medicament

An organic solvent and preparation technology, which is applied in the field of soft capsules containing cidofovir and its preparation, and can solve the problems of low oral bioavailability of cidofovir and the like

Inactive Publication Date: 2010-06-30
BEIJING TRADE STAR MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the in vivo permeability of fusidofovir and the solubility related to the pH value in the body, the oral bioavailability of cidofovir is very low, only less than 5.3%.

Method used

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  • Oral antiviral medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 1 kg of gelatin, 0.4 kg of glycerin, and 1 kg of pure water to heat the sol, add an appropriate amount of preservative to prepare rubber, accurately weigh 50 g of cidofovir, disperse in 112 g of polyethylene glycol 400, and add appropriate amount of water. Prepare 3500 soft capsules through a soft capsule machine, dry, wash, and dry.

Embodiment 2

[0027] Weigh 1kg of gelatin, 0.4kg of glycerin, 1kg of pure water to heat the sol, add appropriate amount of preservatives, and prepare rubber; accurately weigh 40g of cidofovir, dissolve in 92g of vegetable oil and 20g of Tween 80, and prepare soft capsules through a soft capsule machine 3600 grains, dry, wash, and dry.

Embodiment 3

[0029] Weigh gelatin 1kg, glycerin 0.4kg, pure water 1kg heating sol, add appropriate amount of preservatives, prepare rubber; accurately weigh 40g of cidofovir, dissolve in 92g propylene glycol 20g Tween 80, prepare soft capsules through a soft capsule machine 3660 grains, dried, washed, and dried.

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PUM

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Abstract

The invention relates to an oral antiviral medicament, namely an oral cidofovir preparation, in particular to a soft capsule comprising the cidofovir and a preparation method thereof.

Description

technical field [0001] The invention relates to a cidofovir preparation, especially a soft capsule containing cidofovir and a preparation method thereof. Background technique [0002] Cytomegalovirus (CMV) is one of the most harmful herpes viruses. The infection rate of the human body is as high as 50%-80%. It is generally invisible infection. When the human immune function is low, such as HIV infection, cancer patients receive radiotherapy, chemotherapy, organ Or bone marrow transplantation with immunosuppressant anti-rejection, etc. will trigger active infection, which can cause acute retinitis, interstitial pneumonia, gastroenteritis and encephalitis, etc., and the blindness or fatality rate of untreated patients is 70%. %above. With the rise of HIV infection rate and the widespread development of organ transplantation, the demand for anti-CMV drugs is also increasing. [0003] Cidofpvir (English name: Cidofpvir) is a ring-opening nucleoside analogue, which can inhibit ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/675A61K47/42A61P31/20A61P31/22
Inventor 张丽李泓利
Owner BEIJING TRADE STAR MEDICAL TECH
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