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Cidofovir injection and preparation method thereof

A technology for cidofovir and injection, applied in the field of cidofovir injection and its preparation, can solve the problems of large volume, inconvenient transportation and use, complicated preparation process, etc.

Inactive Publication Date: 2008-12-03
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] CN1559429 discloses a preparation method of cidofovir freeze-dried powder for injection, but its preparation process is relatively complicated; CN1559430 discloses a preparation method of cidofovir large infusion preparation, but due to its large volume, it is difficult to transport And use is all not very convenient; CN1698643 discloses a kind of cidofovir liposome and preparation method thereof, but preparation process is complicated, and process reproducibility is relatively poor

Method used

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  • Cidofovir injection and preparation method thereof
  • Cidofovir injection and preparation method thereof
  • Cidofovir injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020] Preparation:

[0021] (1) The glass ampoules are processed according to the routine requirements for injections and kept for later use;

[0022] (2) Weigh the prescribed amount of cidofovir into the liquid preparation tank, add an appropriate amount of water for injection, stir to dissolve, add the prescribed amount of sodium chloride and tert-butyl p-hydroxyanisole, stir to dissolve, add water for injection to the prescription quantity;

[0023] (3) Add an appropriate amount of activated carbon for needles, absorb the activated carbon for 30 minutes, filter and decarburize with filter paper, adjust the pH value, and fine filter;

[0024] (4) Determine the filling amount according to the content of the semi-finished product, fill, seal, and sterilize by autoclaving at 105-121°C.

Embodiment 2

[0026]

[0027] Preparation:

[0028] (1) The glass ampoules are processed according to the routine requirements for injections and kept for later use;

[0029] (2) Weigh the prescribed amount of cidofovir in the liquid preparation tank, add an appropriate amount of water for injection, stir to dissolve, add the prescribed amount of glycerin and fennel, stir to dissolve, and add water for injection to the prescribed amount;

[0030] (3) Add an appropriate amount of activated carbon for needles, absorb the activated carbon for 30 minutes, filter and decarburize with filter paper, adjust the pH value, and fine filter;

[0031] (4) Determine the filling amount according to the content of the semi-finished product, fill, seal, and sterilize by autoclaving at 105-121°C.

Embodiment 3

[0033]

[0034] Preparation:

[0035] (1) The glass ampoules are processed according to the routine requirements for injections and kept for later use;

[0036] (2) Weigh the prescribed amount of cidofovir in the liquid preparation tank, add an appropriate amount of water for injection, stir to dissolve, add the prescribed amount of glycerin and fennel, stir to dissolve, and add water for injection to the prescribed amount;

[0037] (3) Add an appropriate amount of activated carbon for needles, absorb the activated carbon for 30 minutes, filter and decarburize with filter paper, adjust the pH value, and fine filter;

[0038] (4) Determine the filling amount according to the content of the semi-finished product, fill, seal, and sterilize by autoclaving at 105-121°C.

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Abstract

The invention discloses an injection containing cidofovir and a preparation method thereof. The injection comprises an active ingredient of cidofovir and excipients. The drug composition is mainly used for the treatment of diseases caused by cytomegalovirus (CMV) infection.

Description

technical field [0001] The invention relates to a cidofovir injection and a preparation method thereof. The injection is mainly used for treating diseases caused by cytomegalovirus (CMV) infection. Background technique [0002] Cytomegalovirus (CMV) is a pathogen that seriously endangers human health. People of all ages may be infected with CMV, especially newborns, organ transplant recipients, and immunocompromised persons such as HIV-infected persons and AIDS patients. After infection with CMV, it is generally asymptomatic and recessive infection. Once the immune function is impaired, it will lead to serious diseases. Its clinical manifestations are fever, lethargy, leukopenia, thrombocytopenia, hepatitis, pneumonia, gastritis and other symptoms of systemic infection; 45 % AIDS patients develop acute retinitis with a high rate of blindness. [0003] Cidofovir (cidofovir) is a ring-opening nucleotide analogue, which can inhibit viral DNA polymerase, has a strong inhibitory...

Claims

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Application Information

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IPC IPC(8): A61K31/675A61K9/08A61P31/22
Inventor 孟凡静
Owner BEIJING D VENTUREPHARM TECH DEV
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