Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of panaxoside Rd in preparing medicament for preventing and curing Alzheimer's disease

A technology of Alzheimer's disease and ginsenosides, applied in the field of medicine

Inactive Publication Date: 2010-07-07
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many achievements have been made in the pathogenesis, gene mapping, diagnosis and treatment of AD, there are still many unknown areas to be further explored.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of panaxoside Rd in preparing medicament for preventing and curing Alzheimer's disease
  • Application of panaxoside Rd in preparing medicament for preventing and curing Alzheimer's disease
  • Application of panaxoside Rd in preparing medicament for preventing and curing Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] Animal experiment:

[0015] Ginsenoside Rd is provided by Guangzhou Tahoe Bio-Pharmaceutical Co., Ltd. and prepared by the method of Chinese patent ZL01803432.2.

[0016] 1 Materials and methods

[0017] 1.1 Experimental animals and grouping

[0018] Male SD rats, provided by the Experimental Animal Center of the Fourth Military Medical University, aged 6 to 7 weeks and weighing 190 to 210 grams, were retrieved 3 days before the experiment and raised in separate cages in a quiet environment. The temperature of the animal room was controlled at 20-24°C, and the humidity was controlled at about 50%. Animals were free to eat and drink, and the daylight cycle was normal. Random grouping: normal control group, sham operation group, AD model group, animals in AD model group were intraperitoneally injected with normal saline or ginsenoside Rd (10 mg / kg). There were 4 animals in each group.

[0019] 1.2 AD model making and administration method

[0020] Dilute Aβ1-40 to 5 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of panaxoside Rd in preparing medicament for preventing and curing Alzheimer's disease. Experiments show that the injury of nerve cells in the Alzheimer's disease can be simulated by three-dimensionally and directionally injecting beta amyloid to bilateral sea horse CA1 areas, the toxicity effect of A beta on the nerve cells can be remarkably relieved by providing the panaxoside Rd in advance, the number and form of propagated and activated astrocytes are recovered to be normal, the ultra microstructures of the abnormal cells in the CA1 areas are improved, the expression of caspase-3 can be obviously reduced, and the panaxoside Rd has obvious protection effect on the injury of the nerve cells in the Alzheimer's disease.

Description

technical field [0001] The invention relates to a new application of ginsenoside Rd, in particular to the application of ginsenoside Rd in the preparation of drugs for preventing and treating Alzheimer's disease, and belongs to the technical field of medicine. Background technique [0002] With the development of society, the phenomenon of population aging has become increasingly obvious, and the prevalence of age-related diseases has increased significantly. Alzheimer's disease (AD) is a common neurodegenerative disease among the elderly. The fourth leading cause of death from malignant tumors and strokes has a huge impact on society, families and individuals. Therefore, AD has become the focus of attention of all countries in the world, and actively looking for methods and effective drugs to prevent and treat AD has become an urgent problem to be solved today. Although many achievements have been made in the pathogenesis, gene mapping, diagnosis and treatment of AD, ther...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/704A61P25/28A61P25/16A61P25/14A61P25/00
Inventor 赵钢刘娟芳史明
Owner FOURTH MILITARY MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com