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Composition for prevention or treatment of disease associated with the production of autoantibody

A technology of autoantibodies and compositions, applied in sexual diseases, metabolic diseases, blood diseases, etc.

Inactive Publication Date: 2010-08-04
UNIVERSITY OF THE RYUKYUS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it is well known that royal jelly has been widely used as a health-maintaining food or a specific health food since ancient times, and since its safety is sufficiently guaranteed, it is highly likely to be practically used as a drug for the prevention and treatment of autoimmune diseases. high

Method used

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  • Composition for prevention or treatment of disease associated with the production of autoantibody
  • Composition for prevention or treatment of disease associated with the production of autoantibody
  • Composition for prevention or treatment of disease associated with the production of autoantibody

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Embodiment

[0037] Hereinafter, the present invention will be further described in detail with reference to specific experimental examples.

[0038] We first orally administered royal jelly to aged mice whose physiological antinuclear autoantibody level was increased, and it was confirmed that the level of antinuclear autoantibody was significantly reduced. Then, autoimmune disease model mice (NZB×NZWF1: B / W F 1 ) was administered with royal jelly, and a significant life-prolonging effect was confirmed compared with the royal jelly non-administration group as a control. In addition, it was also confirmed that indicators indicating the onset of autoimmune diseases, such as the amount of urine protein, the level of anti-erythrocyte autoantibody, and the level of antinuclear autoantibody, were significantly suppressed.

[0039] SLE Research Model

[0040] As described above, most autoimmune diseases have unclear pathogenesis and are diseases that are contrary to the principle that the immu...

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PUM

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Abstract

Disclosed is a composition for the prevention or treatment of a disease associated with the production of an autoantibody. Specifically disclosed is a composition for the prevention or treatment of a disease associated with the production of an autoantibody, which comprises a royal jelly as an active ingredient.

Description

technical field [0001] The present invention relates to compositions for preventing or treating diseases associated with autoantibody production. Background technique [0002] Autoimmune diseases are diseases in which the immune response that originally functions to protect our body targets our own cells and tissues, resulting in various diseases. Rheumatoid arthritis, myasthenia gravis, and systemic lupus erythematosus (SLE) are mostly refractory diseases. In addition, many parts of the pathogenesis of autoimmune diseases remain unclear. Therefore, in its treatment, it is in a dilemma that it is necessary to suppress immunity while maintaining its own resistance. In reality, there is no radical cure. [0003] Therefore, development of compositions for preventing or treating diseases associated with autoantibody production has been desired. [0004] Royal jelly, on the other hand, is a milky-yellow-white gelatinous liquid that workers of honeybees consume mainly pollen du...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P1/04A61P3/10A61P5/38A61P7/06A61P13/12A61P15/08A61P17/00A61P17/02A61P19/02A61P21/00A61P21/04A61P25/00A61P27/02A61P29/00A61P37/00A61P37/02A23L21/20A61K35/644
CPCA61K35/644A61K35/744A23L2/52A61K35/64A23L1/076A23L21/20A61P1/04A61P13/12A61P15/08A61P17/00A61P17/02A61P19/02A61P21/00A61P21/04A61P25/00A61P27/02A61P29/00A61P37/00A61P37/02A61P37/06A61P5/38A61P7/06A61P3/10A61K2300/00
Inventor 山口喜久二佐藤良也凯伊萨·曼诺尔岛袋勋
Owner UNIVERSITY OF THE RYUKYUS