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Microfluidic apparatus for manipulating, imaging and analyzing cells

A technology of microfluidics and equipment, applied in the field of processing biological samples, can solve the problems that are not suitable for the preparation and analysis of cervical cytology

Inactive Publication Date: 2010-08-18
西泰克公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, microfluidic devices and research are known to be unsuitable for cervical cytology and the associated preparation and analysis of such samples

Method used

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  • Microfluidic apparatus for manipulating, imaging and analyzing cells
  • Microfluidic apparatus for manipulating, imaging and analyzing cells
  • Microfluidic apparatus for manipulating, imaging and analyzing cells

Examples

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Embodiment Construction

[0047] In the following description, reference is made to the accompanying drawings which form a part hereof, and which illustrate by way of illustration certain embodiments and show how these embodiments may be practiced. It should be understood that changes may be made to these examples without departing from the scope of the invention, as embodied in these examples.

[0048] refer to Figure 8A A microfluidic device 800 constructed in accordance with one embodiment and configured for isolating individual cells 16 and / or cell populations 17 in a cell sample includes a base or bottom member 810 (collectively base 810), a microfluidic cell separation element 820 ( collectively referred to as separation element 820), and fluid inlet or inlet tube 831 (collectively referred to as fluid inlet 831), fluid outlet or outlet tube 832 (collectively referred to as fluid outlet 832), or fluid manifold (manifold) ( Figure 8A not shown). Microfluidic device 800 is configured such that ...

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Abstract

A microfluidic apparatus for isolating and imaging or analyzing cells of a cytological specimen includes a substrate and a microfluidic cellular isolation element that includes an outer wall, a channel, a partition member and a receptacle. The partition member is positioned within the isolation element interior, and the receptacle is positioned within the partition member interior. The isolation element is configured such that fluid introduced through the outer wall inlet flows through the channel in a first direction, and the partition member is situated such that fluid flows from the channel into the partition member interior through the partition member inlet aperture in a second direction different than the first direction. The receptacle positioned relative to the partition member inlet to catch and retain a cell carried by the fluid.

Description

technical field [0001] The field of the invention relates to the processing of biological samples, and more particularly to the separation and imaging of cells of biological samples using microfluidics devices. Background technique [0002] Medical professionals and technicians typically prepare biological samples on sample supports, such as glass sample slides, and observe the samples to analyze whether a patient has or may have a particular medical condition or disease. For example, as part of Pap smears and other cancer tests, samples are examined to detect malignant or pre-malignant cells. After a sample slide has been prepared, an automated system can analyze the sample and serve to focus the technician's attention on the most relevant cells or groups of cells, while forgoing further examination of less relevant cells. [0003] Although Pap smears are well known, they are difficult to image due to variable sample thickness, among other reasons. To address these issues...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N1/40
CPCG01N1/2813B01L2200/0668B01L2400/086G01N2015/1006
Inventor 霍华德·考夫曼
Owner 西泰克公司