Pyrimidine and pyridine derivatives and their pharmaceutical use and compositions

Abstract

The prsent invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds as anti-inflammatory agents.

Description

technical field The present invention relates to pyrimidine and pyridine derivatives. This compound has been shown to inhibit matrix metalloproteinases. These compounds are useful in the treatment of diseases resulting from MMP-mediated tissue failure, such as heart disease, cardiac insufficiency, inflammatory bowel disease, multiple sclerosis, osteoarthritis, rheumatoid arthritis, osteoarthritis or similar Arthritis other than rheumatoid arthritis, heart failure, age-related macular degeneration, chronic obstructive pulmonary disease, asthma, periodontal disease, psoriasis, arteriosclerosis, fibrotic conditions in the kidneys or lungs, and / or osteoporosis . Background technique Matrix metalloproteinases (sometimes referred to as MMPs) are naturally occurring enzymes found in most mammals. Overexpression and activation of MMPs or an imbalance between MMPs and MMP inhibitors has been proposed as a causative factor in diseases characterized by failure of the extracellular m...

AI Technical Summary

Problems solved by technology

However, no selective or non-selective MMP-13 inhibitors have been approved and marketed for the treatment of any disease in any mammal

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