Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues

Abstract

Based on our identification of a polypeptide (Angiopep-7) that is efficiently transported to cells such as liver, lung, kidney, spleen, and muscle, the invention provides polypeptides, conjugates including the polypeptides, and methods for treating diseases associated with these cell types. Unlike other aprotinin related polypeptides identified herein (including Angiopep-3, Angiopep-4a Angiopep-4b Angiopep-5, and Angiopep-6) which efficiently cross the blood-brain barrier (BBB), Angiopep-7 is not efficiently transported across the BBB.

Description

Aprotinin-like polypeptide for delivery of reagents conjugated to it to tissue Technical field The present invention relates to improvements in the field of drug delivery. More specifically, the present invention relates to polypeptides, conjugates and pharmaceutical compositions comprising the polypeptides of the present invention, and their use for transporting agents (eg therapeutic agents) into specific cell types such as liver, lung or kidney. Background technique Liver diseases, including hepatitis (for example, viral hepatitis) and liver cancers (for example, liver cancer), and lung diseases, such as lung cancer (for example, small cell and non-small cell lung cancer) are serious health problems. Many therapeutic agents for such diseases have undesirable side effects (e.g. chemotherapeutics), or due to reasons such as in vivo stability, transport or other pharmacokinetic properties, it is difficult to provide a high enough concentration or long enough in the target tiss...

AI Technical Summary

Problems solved by technology

Many therapeutic agents for such diseases have undesired side effects (e.g. chemotherapeutics) or are difficult to provide in the target tissue at sufficiently high concentrations or for a sufficiently long time due to reasons such as in vivo stability, transport, or other pharmacokinetic properties. duration to achieve maximum efficacy in the target tissue

Images