Pyrazole derivatives and preparation method and application thereof

Abstract

The invention belongs to the technical field of antifungal action medicine and provides pyrazole derivatives of the structure in the general formula I and pharmaceutically acceptable salts thereof. The definition of R is stated as in a specification. The invention also relates to a preparation method of the compounds and discloses a pharmaceutical composition which takes the compounds and the pharmaceutically acceptable salts as effective active components and the application in antifungal medicine.

Description

technical field The invention belongs to the technical field of medicine, more specifically, relates to a class of compounds with antifungal activity, its preparation method, composition and application. Background technique Fungal infections can be divided into superficial and deep types according to the different parts of their invasion. Superficial fungal infection is a common and frequently-occurring disease, mostly seen on the skin and nails; deep fungal infections are more common Candida albicans and Cryptococcus neoformans, although the incidence rate is low but the harm is greater, and severe infection can be life-threatening. Especially in recent decades, with the widespread use of broad-spectrum antibiotics, corticosteroids, antineoplastic drugs and immunosuppressants, the widespread implementation of radiotherapy and organ transplantation, the widespread development of catheters and intubations, and the widespread use of immunocompromised patients The rapid incre...

AI Technical Summary

Problems solved by technology

In addition, the interaction between drugs makes the treatment of deep fungal infections more complicated. Therefore, there is an urgent clinical need for new deep antifungal drugs with high efficiency, low toxicity, wide antibacterial spectrum and high selectivity.

Images