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Bio-particle three-dimensional manipulation device based on permanent magnet

A technology for biological particles and manipulation devices, which is applied in the field of special equipment in the field of life science and technology, can solve problems such as explanation of implementation plans, and achieve the effect of simple device structure

Inactive Publication Date: 2010-09-01
SHANGHAI JIAO TONG UNIV
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  • Abstract
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Problems solved by technology

[0004] After searching the prior art, it was found that Adam Winkleman et al published in Applied physics letters (Applied Physics Letters), 2004, 85 (12): 2411-2413: Amagnetic trap for living cells suspended in a paramagnetic buffer (paramagnetic buffer A magnetic trap for suspending living cells in liquid), this article only mentions the use of magnetic Archimedes anti-magnetic levitation technology to suspend substances as an academic research, but does not explain the implementation of the corresponding technology

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  • Bio-particle three-dimensional manipulation device based on permanent magnet
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  • Bio-particle three-dimensional manipulation device based on permanent magnet

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Embodiment Construction

[0019] The embodiments of the present invention are described in detail below. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following implementation example.

[0020] Such as figure 1 As shown, this embodiment includes: a base 1, a main shaft 2, a mobile platform 3, a holder 4, a chamber 5, a paramagnetic solution 6, a magnetic source 7 and biological particles 8, wherein: the main shaft 2 is fixed on the base 1 , the main shaft 2 is movable with a mobile platform 3, the holder 4 is socketed on the main shaft 2, the holder 4 holds the chamber 5, the magnetic source 7 is arranged on the mobile platform, and the chamber 5 is provided with a paramagnetic solution 6. Biological particles 8 are placed in the paramagnetic solution 6 , and the holder 4 is located on the mobile ...

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Abstract

The invention discloses a bio-particle three-dimensional manipulation device based on a permanent magnet, belonging to the technical field of life science. The bio-particle three-dimensional manipulation device comprises a base, a main shaft, a mobile platform, a clamp holder, a chamber, a paramagnetism solution and a magnetic source, wherein the base is fixed with the main shaft, the main shaft is movably provided with the mobile platform, the clamp holder is sleeved on the main shaft and clamps the chamber, the magnetic source is arranged on the mobile platform, the chamber is internally provided with the paramagnetism solution, and the clamp holder is positioned on the mobile platform. The invention has simple structure and can realize various modes of spatial bio-particle micro-manipulation, such as non-contact and no-damage spatial capture, location, movement and the like of biological active particles under an environment with normal temperature and non-superconductivity strong magnetism.

Description

technical field [0001] The invention relates to a special equipment in the technical field of life sciences, in particular to a three-dimensional biological particle manipulation device based on a permanent magnet. Background technique [0002] In the field of life sciences, the manipulation, capture, and movement of single or several biological particles without damage is the basis for the manipulation, processing, and testing of biological objects. Chromosome and cell analysis, protein and nucleic acid aggregation analysis, new species generation and other life science fields have great theoretical and practical significance. [0003] At present, the micro-manipulation of biological particles mainly includes contact mechanical micro-tweezers, non-contact magnetic tweezers, non-contact optical tweezers, and biological micro-manipulation based on dielectrophoresis. Contact micro-manipulation methods are easy to affect the activity of biological particles. The magnetic tweez...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/42
CPCC12M23/20C12M35/06C12M35/02
Inventor 张卫平李世鹏陈文元刘武胡牧风
Owner SHANGHAI JIAO TONG UNIV
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