Novel isoquinoline alkaloid derivatives and preparation method and application thereof

A compound, isopropyl technology, applied in the field of new isoquinoline alkaloid derivatives and their preparation and application, can solve the problem of unsatisfactory therapeutic effect

Inactive Publication Date: 2010-09-15
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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However, the current effect of most ty...

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  • Novel isoquinoline alkaloid derivatives and preparation method and application thereof
  • Novel isoquinoline alkaloid derivatives and preparation method and application thereof
  • Novel isoquinoline alkaloid derivatives and preparation method and application thereof

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Abstract

The invention discloses tetrahydropalmatine derivatives and a preparation method and application thereof. The structural formula of the tetrahydropalmatine derivatives is shown as a formula II, wherein R is octyl, isopropyl or 3-methybutyl. The provided application is the application of the tetrahydropalmatine derivatives shown as the formula II or pharmaceutically acceptable salts thereof in the preparation of eukaryotic tumor cell antiblastics and medicaments for preventing and/or treating tumors. The results of in-vitro anti-tumor activity experiments prove that each tetrahydropalmatine derivative has the effect of inhibiting human lung cancer cells A-549, KB human nasopharyngeal carcinoma cells, and HL-60 leukemia cell strains to a certain extent. The results show that the tetrahydropalmatine derivatives shown as the formula II can be applied to preparing the medicaments for treating the tumors, and the pharmaceutical application of the tetrahydropalmatine derivatives is widened.

Description

technical field The invention relates to a novel isoquinoline alkaloid derivative, a preparation method and application thereof. Background technique Malignant tumor is one of the major diseases that endanger human health and life. In my country, according to the statistics of the Ministry of Health, the total number of new tumor patients is about 2.127 million each year, of which there are about 1.06 million new patients with malignant tumors. At the same time, there are about 2.685 million cancer patients in hospital across the country, of which about 1.485 million patients with malignant tumors are currently in hospital. Although important progress has been made in the research and development and application of anticancer drugs for more than half a century, chemotherapy for certain types of tumors has achieved outstanding curative effects. However, the effect of most types of drug treatment is still unsatisfactory. Therefore, the discovery and development of new anti-...

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Application Information

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IPC IPC(8): C07D455/03A61K31/4375A61P35/00A61P35/02
Inventor 张虹沈刚金雪刘岩唐亚林
Owner INST OF CHEM CHINESE ACAD OF SCI
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