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Application of isopentene group flavonoid compound used as pancreatic lipase inhibitor

A technology of pancreatic lipase and compounds, applied in the field of prenyl flavone compounds as pancreatic lipase inhibitors

Inactive Publication Date: 2010-09-22
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no report about inhibiting pancreatic lipase activity of the compound shown in formula (I)

Method used

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  • Application of isopentene group flavonoid compound used as pancreatic lipase inhibitor
  • Application of isopentene group flavonoid compound used as pancreatic lipase inhibitor
  • Application of isopentene group flavonoid compound used as pancreatic lipase inhibitor

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Abstract

The invention belongs to the technical field of medicaments, and in particular relates to application of isopentene group flavonoid compound used as a pancreatic lipase inhibitor. The flavonoid compound has the following structural formula and has a chemical name of: (E)-2-(2,4-dihydroxy phenyl)-5,7-dihydroxy-3-(3-methyl-2-butenyl)-6-(3-methy-l-butenyl)-4H-chromene-4-ketone, and can be extracted from artocarpus nitidus. Pancreatic lipase activity tests and experiments of weight loss action in animals prove that the compound has obvious pancreatic lipase inhibitory activity and weight loss action, can be taken as the lead compound for developing novel medicaments for preventing or curing obesity and related metabolic diseases, and also can be used for preparing the medicaments for preventing and curing clinically common multiple obesity and the related metabolic disease.

Description

technical field The invention belongs to the technical field of medicine, and more specifically, the invention relates to the use of a prenyl flavonoid compound isolated from laurel wood as a pancreatic lipase inhibitor. Background technique In the past 20 years, the incidence of obesity has been increasing all over the world, especially in developed countries. Due to the rapid development of the economy and the continuous improvement of living standards, the problems of insufficient exercise and relative excess energy intake have always existed in the lifestyle of modern people, which has led to the energy intake of many modern people exceeding energy consumption, and the excess energy will be Part of it is stored as fat in adipose tissue, and its accumulation can lead to obesity and related diseases, such as diabetes, cancer, heart disease, hyperlipidemia, and fatty liver. Currently, the treatment of obesity consists mainly in the development of drugs that increase energ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P43/00A61P3/04
Inventor 王贺瑶侯爱君朱维良闫桂蕊赵婷
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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