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Process for preparing general flavone extract of effective part of hypericum ascyron linne and new medicament appliaciton

A technology of effective parts and Eclipta, applied in the field of biomedicine, can solve problems such as no application

Inactive Publication Date: 2010-11-10
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that it has anti-asthma, expectorant, antitussive, and antibacterial effects, but there is no information about its application in the treatment of hepatitis B.

Method used

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  • Process for preparing general flavone extract of effective part of hypericum ascyron linne and new medicament appliaciton
  • Process for preparing general flavone extract of effective part of hypericum ascyron linne and new medicament appliaciton

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1 Preparation of effective fractions of total flavonoids of Eclipta chinensis

[0011] Add an appropriate amount of 80% ethanol to the red eclipta, extract once, extract for 2 hours, combine the extracts, filter, concentrate the filtrate into a concentrated solution with a relative density of 1.13-1.16 at 60°C, add an appropriate amount of water to sink for 24 hours, and filter with suction , concentrated to the corresponding volume, passed through a macroporous adsorption resin column, and eluted with an alcohol-water gradient, 3 column volumes for water elution, 3 column volumes for 10% and 30% ethanol, and 1 column volume for 70% ethanol elution volume. The eluate is concentrated, dried and pulverized to obtain the total flavonoid extract of Eclipta chinensis, the total flavonoid content of which is 65%.

Embodiment 2

[0012] Example 2 Preparation of Capsules of Effective Fractions of Total Flavonoids of Eclipta chinensis

[0013] Take 250g of the extract of effective parts of total flavonoids of Eclipta chinensis and 50g of magnesium stearate, pass through an 80-mesh sieve, mix thoroughly, dry granulate, and fill 1000 capsules, each containing 250 mg of effective parts of total flavonoids of Eclipta chinensis. Usage: 2 capsules each time, three times a day.

Embodiment 3

[0014] Example 3 Preparation of tablets of effective fractions of total flavonoids of Eclipta chinensis

[0015] Take 250g of the extract of effective parts of total flavonoids of Eclipta chinensis and 45g of microcrystalline cellulose, mix well, wet granulate with ethanol, and pass through a 20-mesh sieve. Add 5 g of magnesium stearate, mix well, and press to form 1000 tablets with a tablet weight of 0.3 g / tablet, each containing 250 mg of active parts of total flavonoids of Eclipta chinensis. Usage: 2 tablets each time, three times a day.

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Abstract

The invention relates to a process for preparing general flavone extract of effective part of Hypericum ascyron linne and new medicament appliaciton, in particular to application of the general flavone extract in preparation of medicaments for treating hepatitis B.

Description

technical field [0001] The present invention belongs to the field of biomedicine, and in particular refers to a new drug application of the effective parts of total flavonoids of Eclipta chinensis, specifically the application in the preparation of medicines for treating hepatitis B, including using the effective parts of total flavonoids of Eclipta chinensis as active ingredients Use of the pharmaceutical composition of the invention in the preparation of medicines for treating hepatitis B. Background technique [0002] Red Eclipta, Hypericum ascyron L., a plant of the genus Hypericum in the family Hypericum, uses the whole herb as medicine. It is also known as Hunan Forsythia and Huang Haitang. It is recorded in "National Chinese Herbal Medicine Compilation". It is cold in nature and slightly bitter in taste. . Have cooling blood to stop bleeding, heat-clearing and toxic substances removing. For hematemesis, hemoptysis, epistaxis, uterine bleeding, jaundice, hepatitis; e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/16A61P31/20
Inventor 张玲凌沛学尚立霞
Owner 凌沛学
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