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Citrus aurantium total flavone extract and the preparing method thereof

A technology of total flavonoids and extracts of Citrus aurantium, which is applied in the field of medicine and can solve problems such as unfavorable large-scale production and complicated preparation methods

Active Publication Date: 2007-10-31
石任兵 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the preparation method of the effective fraction of flavonoids of citrus citrus flavonoids is only disclosed in the patent literature with the invention patent No.

Method used

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  • Citrus aurantium total flavone extract and the preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Preparation process of Fructus Aurantii total flavonoids extract

[0037] Take 1 kg of decoction pieces of Fructus Aurantii, add 10L of water and reflux for extraction 3 times, each extraction is 2 hours, and the solvent is recovered under reduced pressure. The loading dilution ratio is 1:10 (based on the crude drug amount), and it passes through 5L AB-8 macroporous adsorption resin, the adsorption flow rate is 3BV / h, the resin column diameter-to-height ratio is 1:8, and the loading volume is 0.2g / mL ( Based on crude drug amount), water eluted 3 times the volume of resin for impurity removal, the impurity removal flow rate was 3 BV / h, 50% ethanol eluted 5 times the volume of resin, the elution flow rate was 5 BV / h, and the 50% ethanol eluate was collected , Recover the solvent and dry under reduced pressure to obtain the total flavonoids extract of Fructus Aurantii. The total flavonoids content in the total flavonoids of Fructus Aurantii was determined to be 74%,...

Embodiment 2

[0038] Example 2: Preparation process of Fructus Aurantii total flavonoids extract

[0039] Take 5kg of Zhishi decoction pieces, 15L of 30% ethanol, reflux extraction for 2 times, extract the solvent for 2 hours each time, recover the solvent, add water to disperse and dissolve the extract, make the sample solution dilution ratio 1:8 (based on crude drug amount), and pass 5L AB-8 macroporous adsorption resin, adsorption flow rate 2BV / h, resin column diameter-to-height ratio is 1:7, sample amount is 0.1g / mL (based on crude drug amount), 10% ethanol eluted 3 times the resin volume for removal The impurity removal flow rate is 2BV / h, 70% ethanol elution is 7 times the volume of the resin, and the elution flow rate is 5BV / h. The 70% ethanol eluate is collected, the solvent is recovered, and dried under reduced pressure, which is the total flavonoid extraction of Fructus Aurantii Things. The content of total flavonoids in the total flavonoids of Fructus Aurantii was determined to be 70...

Embodiment 3

[0040] Example 3: Preparation process of Fructus Aurantii total flavonoids extract

[0041] Take 10kg of Zhishi decoction pieces, add 50% ethanol and 12L reflux extraction for 3 times, extract 1.5 hours each time, recover the solvent, add water to disperse and dissolve the extract, make the sample solution dilution ratio 1:6 (based on crude drug amount), pass 7L AB-8 macroporous adsorption resin, the adsorption flow rate is 4BV / h, the resin column diameter-to-height ratio is 1:6, the sample amount is 0.3g / mL (based on crude drug amount), 20% ethanol eluted twice the resin volume for removal Impurity removal flow rate is 2BV / h, 90% ethanol elution is 4 times the volume of resin, elution flow rate is 4BV / h, 90% ethanol eluate is collected, solvent is recovered, and dried under reduced pressure, which is the extraction of total flavonoids from Fructus Aurantii Things. The content of total flavonoids in the total flavonoid extract of Fructus Aurantii was determined to be 80%, and the ...

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PUM

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Abstract

The invention discloses a total chromocor extract from traditional medicine citrus fruit and preparing method, which is characterized by the following: comprising pomelo ped glycosides, new orange peel glycosides, orange peel glycosides, pomelo ped rutin, derivant and so on; choosing one or several methods from solvent extraction, solvent extraction process, macroreticular absorption resin method, lead salt precipitation method, column chromatography, supercritical fluid chromatography, liquid-liquid counter-current partition chromatography and so on; producing extract; setting percentage content of various chromocor element at 5-100%(w / w) in the extract; counting 5-100%(w / w) of pomelo ped glycosides, new orange peel glycosides, orange peel glycosides in total chromocor content.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a total flavonoid extract of Chinese medicine Hovenia aurantium, a preparation method, a quality control method and its application in the field of medicine and health food. Background technique [0002] Citrus aurantium is a commonly used traditional Chinese medicine, derived from the dried young fruit of Citrus aurantium L. and its variants or Citrus sinensis Osbeck. Traditional Chinese medicine theory believes that Citrus aurantium has the effects of dispelling qi and accumulating, resolving phlegm and dispelling pimple. It is used for stagnation and internal stagnation, fullness of swelling and pain, diarrhea, dysentery, obstruction of stool, phlegm stagnation and qi blocking chest numbness, chest congestion, Gastroptosis, anus prolapse, uterine prolapse. Modern pharmacological studies have shown that Citrus aurantium can enhance myocardial contractility, slow down hea...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/00A23L2/52A61P1/00A61P9/06A61P9/10C07H1/08A61K131/00
CPCY02P20/54
Inventor 石任兵刘斌李军董志滨
Owner 石任兵
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