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Magnetic washing for biosensor

A sensor and magnetic field generator technology, applied in the field of sensing equipment, can solve problems such as requiring photoexcitation steps, inability to distinguish specific binding molecules from non-specific binding molecules, and no suggestion given.

Inactive Publication Date: 2010-11-17
KONINK PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A review document on protein microarray technology in December 2002 (Macbeath (2002) Nature Genetics 32, S526-532) mentioned the issue of assessing specificity as a key feature of protein microarray technology, but did not give recommendations possible solution
Disadvantages of the photoaptamer approach are that it requires the design of new photoaptamers for each target, requires a photoexcitation step, the photocrosslinking step itself does not distinguish between specific and nonspecific binding molecules, and it is an endpoint assay. method

Method used

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  • Magnetic washing for biosensor
  • Magnetic washing for biosensor
  • Magnetic washing for biosensor

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Embodiment Construction

[0030] The present invention will be described with respect to particular embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. The drawings described are illustrative only and not limiting. In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for illustrative purposes. When the term "comprising" is used in the present description and claims, it does not exclude other elements or steps. When an indefinite or definite article is used when referring to a singular noun eg "a", "an", "the", this includes a plurality of such nouns unless something else is specifically stated.

[0031] The term "comprising", used in the claims, should not be understood as limiting the means listed thereafter, it does not exclude other elements or steps. Therefore, the scope of the expression "apparatus including devices A and B" should not be limited to an apparatus including components A and B onl...

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Abstract

Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.

Description

technical field [0001] The invention relates to a sensing device for detecting magnetized or magnetizable target components in a fluid containing magnetized or magnetizable target components as well as other magnetizable or magnetizable target components, to a corresponding detection method, to software for controlling such a device , and corresponding methods involving the manufacture of such devices. Background technique [0002] Biochemical and medical diagnostic assays such as protein microarrays or other methods are known to determine interactions between microbial entities such as viruses, protozoa, bacteria, their organelles, liposomes and proteins such as proteins or DNA bioactive molecules. [0003] US 2005 / 0048599A1 discloses a method for studying microorganisms labeled with particles such that (eg magnetic) forces can be exerted on them. In one embodiment of the method, a light beam is directed through a transparent material to its totally internally reflected s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543
CPCG01N21/648G01N27/745G01N33/54326G01N21/552
Inventor F·K·德泰耶D·M·布鲁斯T·范德维克C·A·费许雷恩A·H·J·伊明克
Owner KONINK PHILIPS ELECTRONICS NV