Method for preparing tiamulin fumarate effervescent granules for livestock and poultry

A technology of Tiamulin fumarate and effervescent granules, applied in the directions of antibacterial drugs, pharmaceutical formulations, drug delivery, etc., to achieve the effects of rapid onset of action, overcoming poor taste and good taste

Inactive Publication Date: 2010-12-01
SRICK TIANJIN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the entire veterinary pharmaceutical industry in my country, veterinary drug preparations are a weak link. Existing veterinary drug forms include tablets, oral liquids, powders, etc., which are far from meeting the needs of the absorption and efficacy of certain drugs in veterinary clinics. Therefore, , strengthen the research and development of new dosage forms, realize the characteristics of timing, positioning, fixed speed and continuous action of drugs according to different requirements, continuously improve the curative effect of drugs, and reduce toxic and side effects are the direction of our efforts in the research and development of dosage forms in the future

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of tiamulin fumarate effervescent granules for livestock and poultry: the steps are:

[0022] (1) All raw and auxiliary materials are pulverized to a particle size of 100 mesh, and set aside;

[0023] (2) Take pulverized tiamulin fumarate, citric acid, polyethylene glycol 6000, dextrin, and sucrose of 1 / 2 of the total amount and mix them uniformly in a tank mixer, add purified water to make a soft material, and prepare granules, dried, whole granules;

[0024] (3) Take the pulverized sodium bicarbonate, put the remaining polyethylene glycol 6000, dextrin, and sucrose into the tank mixer and mix evenly, add purified water to make a soft material, granulate, dry, and granulate;

[0025] (4) Put the dry granules of (2) and (3) above into a three-dimensional mixer to mix evenly, and pack separately.

[0026] Each raw material and parts by weight thereof are respectively:

[0027] Tiamulin fumarate: 80 parts; citric acid: 100 parts; sodium bicarbonate...

Embodiment 2

[0031] A preparation method of tiamulin fumarate effervescent granules for livestock and poultry, the steps are:

[0032] (1) All the raw and auxiliary materials are pulverized to a particle size of 110 mesh, and set aside;

[0033] (2) Take pulverized tiamulin fumarate, citric acid, polyethylene glycol 6000, dextrin, and sucrose of 1 / 2 of the total amount and mix them uniformly in a tank mixer, add purified water to make a soft material, and prepare granules, dried, whole granules;

[0034] (3) Take the pulverized sodium bicarbonate, put the remaining polyethylene glycol 6000, dextrin, and sucrose into the tank mixer and mix evenly, add purified water to make a soft material, granulate, dry, and granulate;

[0035] (4) Put the dry granules of (2) and (3) above into a three-dimensional mixer to mix evenly, and pack separately.

[0036] Each raw material and parts by weight thereof are respectively:

[0037] Tiamulin fumarate: 100 parts; citric acid: 120 parts; sodium bicarb...

Embodiment 3

[0039] A preparation method of tiamulin fumarate effervescent granules for livestock and poultry, the steps are:

[0040] (1) All the raw and auxiliary materials are crushed to a particle size of 120 mesh, and set aside;

[0041] (2) Take pulverized tiamulin fumarate, citric acid, polyethylene glycol 6000, dextrin, and sucrose of 1 / 2 of the total amount and mix them uniformly in a tank mixer, add purified water to make a soft material, and prepare granules, dried, whole granules;

[0042] (3) Take the pulverized sodium bicarbonate, put the remaining polyethylene glycol 6000, dextrin, and sucrose into a tank mixer and mix evenly, add purified water to make a soft material, granulate, dry, and granulate;

[0043] (4) Put the dry granules of (2) and (3) above into a three-dimensional mixer to mix evenly, and pack separately.

[0044] Each raw material and parts by weight thereof are respectively:

[0045] Tiamulin fumarate: 120 parts; citric acid: 140 parts; sodium bicarbonate...

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Abstract

The invention relates to a method for preparing tiamulin fumarate effervescent granules for livestock and poultry, which comprises the following steps of: taking raw and auxiliary materials in part by weight for later use; mixing the weighed and crushed tiamulin fumarate, citric acid, polyethylene glycol 6000 in an amount which is one second of the total amount, dextrin and sucrose uniformly in a groove-shaped mixer, adding purified water into the mixture to prepare a soft material, granulating and drying the soft material, and settling the granules; weighing crushed sodium bicarbonate, mixing the reset auxiliary materials in the groove-shaped mixer uniformly, adding purified water into the mixture to prepare a soft material, granulating and drying the soft material, and settling the granules; and mixing the two kinds of dried granules uniformly in a three-dimensional mixer, and packing the mixed granules. The prepared tiamulin fumarate effervescent granules have the advantages of good mouthfeel and stable quality after oral administration of sick livestock and poultry, and are an ideal preparation for treating mycoplasma pneumonia, actinomycetic pleuropneumonia and treponema dysentery at present.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a method for preparing tiamulin fumarate effervescent granules for livestock and poultry. Background technique [0002] In the entire veterinary pharmaceutical industry in my country, veterinary drug preparations are a weak link. Existing veterinary drug forms include tablets, oral liquids, powders, etc., which are far from meeting the needs of the absorption and efficacy of certain drugs in veterinary clinics. Therefore, , strengthen the research and development of new dosage forms, realize the characteristics of timing, positioning, fixed speed and continuous action of drugs according to different requirements, continuously improve the curative effect of drugs, and reduce toxic and side effects are our future efforts in research and development of dosage forms. [0003] Effervescent granules are a novel dosage form. The difference between them and ordinary granules is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/22A61P31/04
Inventor 王洪杰苏永鹏黄健刘志辉
Owner SRICK TIANJIN BIO TECH
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