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Aqueous dispersion containing polysaccharide particulate gel and method for producing the same

A polysaccharide and dispersion technology, which can be used in medical preparations with non-active ingredients, preparations for skin care, and liquid delivery, etc., can solve problems such as inability to apply, achieve good drug efficacy sustainability, and inhibit the loss of effective ingredients. , the effect of high in vivo safety

Inactive Publication Date: 2011-01-05
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the viscosity of an ophthalmic composition based on a polysaccharide-containing composition has increased by at least several tens of mpa·s compared to before sterilization, so it may not be applicable to eye drops or contact lens preservatives. etc. for actual product issues

Method used

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  • Aqueous dispersion containing polysaccharide particulate gel and method for producing the same
  • Aqueous dispersion containing polysaccharide particulate gel and method for producing the same
  • Aqueous dispersion containing polysaccharide particulate gel and method for producing the same

Examples

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Effect test

preparation example Construction

[0078] The method for preparing a polysaccharide particulate gel-containing aqueous dispersion of the present invention is characterized by comprising the steps of: heating the polysaccharide in an aqueous medium to a gel transition temperature or higher, and dissolving the polysaccharide in the above-mentioned A dissolving step in an aqueous medium; a step of cooling the polysaccharide dissolved in the aqueous medium to below the gel transition temperature while applying an external force, and making the polysaccharide into a particulate gel; cooling the polysaccharide in the aqueous medium The step of irradiating the above-mentioned particulate gel with ionizing radiation to obtain an aqueous dispersion containing polysaccharide particulate gel.

[0079] "The dissolving step of heating the polysaccharide in an aqueous medium to a temperature above the gel transition temperature to dissolve the polysaccharide in the aqueous medium" can be carried out according to methods descr...

Embodiment 1

[0120] (Preparation of aqueous dispersion containing agar microgel)

[0121] Weigh 0.5% (weight) of agar (AX-30, manufactured by Ina Food Industry) in a closed container, add 99.5% (weight) of distilled water (distilled water for injection, prepared by Dazhuo Pharmaceutical Co., Ltd.) to disperse the agar. Then, the airtight container was immersed in an oil bath set at 100° C., and stirred at 700 rpm for 30 minutes using a mechanical stirrer (BL-600, manufactured by HEIDON) to dissolve the agar. Then the airtight container was lifted from the oil bath, and left to cool at room temperature for 210 minutes while stirring at 700 rpm using a mechanical stirrer to prepare an aqueous dispersion containing agar microgel (hereinafter referred to as aqueous dispersion A).

[0122] (Irradiation of aqueous dispersions containing agar microgels)

[0123] 10 ml of aqueous dispersion A containing particulate agar was collected, put into an airtight container, and gamma rays were irradiated...

Embodiment 2

[0127] 10 ml of aqueous dispersion A containing particulate agar was collected, put into a closed container, and the liquid depth was 5 mm, and irradiated with electron beams at an irradiation voltage of 5 MeV and a dose of 25 kGy to obtain aqueous dispersion C. Then, the same heat resistance evaluation test as in Example 1 was performed.

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Abstract

Disclosed is an aqueous dispersion containing polysaccharide particulate gels, which is characterized by containing particulate gels substantially composed of a polysaccharide. The aqueous dispersion containing polysaccharide particulate gels is also characterized in that shapes of the particulate gels are maintained even after the particulate gels are heated for 30 minutes at 95 DEG C in an aqueous medium. Namely, disclosed is an aqueous dispersion containing polysaccharide particulate gels, wherein the particulate gels are composed of a polysaccharide and have shapes that can be maintained even after 30-minute heating in an aqueous medium of 95 DEG C.

Description

technical field [0001] The present invention relates to an aqueous dispersion containing polysaccharide particulate gel and a process for its preparation. Background technique [0002] In the fields of pharmaceuticals, medical materials, foods, cosmetics, etc., many polysaccharide-containing products having various forms have been developed, and gel-like products have also been proposed. [0003] Compositions containing polysaccharides are known to improve spreadability (coatability), living body safety, or drug retention. For example, compositions containing polysaccharides are described in Patent Documents 1 to 3. and its preparation method, the polysaccharide-containing composition is obtained as follows: polysaccharides are dissolved in an aqueous medium at a temperature higher than the gel transition temperature, and cooled to below the gel transition temperature while applying shear force, Thereby, part or all of the polysaccharides are made into fine particles, and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075A61K8/73A61K9/06A61K47/36A61Q19/00C08J3/28C08L3/00C08L5/00A23L29/20
CPCC08J2305/00C08J2305/12A61K9/0014A61K9/06C08L5/12C08B37/0039A61K9/10A61Q19/00C08L5/00C08J3/075A61K8/042C08J3/05A61K47/36A61K8/73A61P27/02
Inventor 奥村博人岛垣昌明谷口孝
Owner TORAY IND INC
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