Application of di-perylene bisimide compound used as photosensitizer

Abstract

The invention discloses novel application of a di-perylene bisimide compound used as a photosensitizer, wherein the di-perylene bisimide compound is shown in a formula I. The inventor considers the property of the di-perylene bisimide as the photosensitizer from four following aspects of: 1, detecting the generation of singlet oxygen; 2, detecting time evolution trends of the triplet of a singlet oxygen precursor DiPBI respectively in aerobic condition and anaerobic condition; 3, quantitatively measuring relative quantum yield of the singlet oxygen generated by the DiPBI compound; and 4, inspecting the photostability of the DiPBI compound. Tests prove that the di-perylene bisimide compound has excellent photoactivating capability, and presents better photostability, can durably develop photoactivating function. Thus, compared with other photosensitizers (such as porphyrins, methylthionine chloride and the like), with remarkable advantages, the di-perylene bisimide compound has wide application prospect.

Description

technical field The invention relates to the application of a diperylimide compound as a photosensitizer. Background technique In photochemical reactions, there is a class of molecules that only absorb photons and transfer energy to other molecules, prompting them to undergo chemical reactions, and return to their original state without participating in the chemical reaction process. Such molecules are called photosensitizers. Photosensitization to generate singlet oxygen has been widely used in the fields of fine synthesis, sewage treatment and photodynamic therapy. Photodynamic therapy has a series of outstanding advantages such as broad-spectrum, precise positioning, easy operation, and no drug resistance. It is a new type of medical technology that is developing rapidly. The photosensitizer is the primary factor affecting the photosensitization effect. An ideal photosensitizer should have the following characteristics: (1) single component, clear structure, and stable p...

AI Technical Summary

Problems solved by technology

However, its disadvantage is that heavy atoms (especially heavy metal atoms) may cause cytotoxicity, which greatly limits the application of such design concepts in photosensitizing drugs.

At present, there is no research report on the application of diperylimide

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