Preparation process of As2O3/Fe3O4 composite nano-particles

A preparation process and nanoparticle technology, applied in the direction of medical preparations containing active ingredients, drug combinations, inorganic active ingredients, etc., can solve the problem of single action, achieve high drug concentration, improve tumor treatment effect, and evenly distribute the effect

Inactive Publication Date: 2011-02-09
SOUTHEAST UNIV
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  • Preparation process of As2O3/Fe3O4 composite nano-particles
  • Preparation process of As2O3/Fe3O4 composite nano-particles
  • Preparation process of As2O3/Fe3O4 composite nano-particles

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Embodiment 1

[0035] As a cancer drug 2 o 3 / Fe 3 o 4 Preparation method of composite nanoparticles:

[0036] Step 1 Apply chemical co-precipitation method to prepare Fe 3 o 4 magnetic nanoparticles

[0037] Analytical pure FeCl 3 ·6H 2 O and FeCl 2 4H 2 O was prepared as FeCl with a molar concentration of 0.1mol / L 3 solution and FeCl 2 solution, by Fe 3+ : Fe 2+ =5:3 volume ratio FeCl with a molar concentration of 0.1mol / L 3 solution and FeCl with a molar concentration of 0.1mol / L 2 The solution was added to the flask and mixed to obtain a mixed solution, and the N 2 Add dropwise NH with a molar concentration of 1.5mol / L under protection and magnetic stirring 4 OH, precipitates appear in the solution, continue to add NH dropwise 4 OH until the pH of the reaction solution is 9, the precipitate gradually turns from reddish brown to black, continue to stir for 30 minutes and then stop, and mature in a water bath at 80°C for 30 minutes, then use a permanent magnet to abs...

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Abstract

The invention provides a preparation process of As2O3/Fe3O4 composite nano-particles, which relates to a novel antitumor medicament preparation process through thermotherapy combined with chemotherapy. The preparation process comprises the following steps of: by applying a chemical coprecipitation method, mixing a FeCl3 solution and a FeCl2 solution according to the mol ratio of 5:3, dropwise adding NH4OH under N2 protection and stirring until the pH of reaction liquid is equal to 9 to generate black precipitates, curing at high temperature, washing and carrying out vacuum drying to prepare Fe3O4 magnetic nano-particles; and by adopting a dipping method, fully mixing As2O3 solutions with different concentrations and pH equal to 5 and a certain mass of Fe3O4 magnetic nano-particles under the condition of ultrasonic dispersion to prepare an As2O3/Fe3O4 nano-composite material through the steps of settling, water bath at high temperature of 80 DEG C, centrifuging, washing, drying, and the like. The prepared As2O3/Fe3O4 composite nano-particles have good magnetic responsiveness and temperature-rising and temperature-controlling capabilities, simultaneously have good biocompatibility and can be further used for tumor thermochemotherapy.

Description

technical field [0001] The technical field of novel anti-tumor traditional Chinese medicine microsphere preparations, especially related to a kind of As 2 o 3 / Fe 3 o 4 Preparation process of composite nanoparticles. Background technique [0002] 1. As 2 o 3 antitumor effect [0003] Chinese medicine arsenic (arsenic trioxide, As 2 o 3 ) and arsenic preparations for the treatment of tumors are research hotspots in recent years, especially the treatment of leukemia has attracted people's attention. Arsenic is a heavy metal that exists widely in trivalent or pentavalent forms. Arsenic has been used as an antitumor drug in my country for hundreds of years. In 1865, Lessauer used oral Fowler's solution (also known as potassium arsenite solution) to treat leukemia, psoriasis, chronic bronchitis, asthma and as a tonic. In 1996, the First Hospital of Harbin Medical University reported the application of arsenic trioxide injection and in 1997, the Institute of Blood Disea...

Claims

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Application Information

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IPC IPC(8): A61P35/02A61P35/00A61P35/04A61K33/36A61K9/14A61K47/02
Inventor 张东生杜益群刘慧
Owner SOUTHEAST UNIV
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