Process for extracting salvianic acid A

Abstract

The invention discloses a process for extracting salvianic acid A. The process comprises the following steps of: (1) performing water extraction on salvia miltiorrhiza decoction pieces twice, adding water, decocting for 1 to 2 hours and mixing the decoction; (2) concentrating to form extract which has relative density of between 1.08 and 1.24 at the temperature of between 50 and 60 DEG C; (3) adding ethanol to ensure that the alcohol content is between 60 and 65 percent, standing and filtering; (4) concentrating the filtrate to form the extract which has the relative density of between 1.08 and 1.24 at the temperature of between 50 and 60 DEG C; (5) adding ethanol to ensure that the ethanol content is between 70 and 75 percent, standing and filtering; (6) concentrating the filtrate to form the extract which has the relative density of between 1.08 and 1.24 at the temperature of between 50 and 60 DEG C, adding water in an amount which is 3 to 4 times the amount of the extract, standing, filtering and concentrating the filtrate to form the extract which has the relative density of between 1.22 and 1.24 at the temperature of between 50 and 60 DEG C; (7) adding 5 to 20 percent aqueousalkali, adjusting the pH to be 10 to 12 and performing intermediate-temperature conversion; and (8) collecting the extract. The production can be realized by the conventional equipment. The salvianicacid A content is increased by 1 to 2 times when the production time is increased by 1 hour. The salvianic acid A contains a small amount of other impurity elements.

Description

technical field [0001] The invention relates to a process for extracting Danshensu, in particular to a new extraction process for extracting Danshensu in medicinal materials of Salvia miltiorrhiza, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] Danshen is the dry root and rhizome of Salvia mikltiorrhiza Bge., a labiata plant. It has the functions of removing blood stasis and relieving pain, promoting blood circulation, clearing the heart and eliminating vexation. . Salvia miltiorrhiza can improve peripheral circulation and microcirculation, has obvious anti-thrombotic and thrombolytic effects, has significant protective effect on ischemic myocardium, and has lipid-lowering and anti-atherosclerotic effects. The clinically used preparations are Compound Danshen Injection, Shenxiong Injection, Danshen Tablets, Xinkeshu Tablets, Danshen Oral Liquid, Danshen Shuxin Capsules, Compound Danshen Tablets, Compound Danshen Dripping P...

AI Technical Summary

Problems solved by technology

[0009] The method disclosed in the Chinese Patent Publication No. CN1670008A is to first extract the Danshen medicinal material with water, and then use dilute alkali to convert the Danshensu precursor of the Danshen water extract into Danshensu. During the conversion process, an antioxidant and an inert gas protection are required. The main disadvantage of the main method is that the operation is complicated, and the water extract of Salvia miltiorrhiza has a large volume, which requires more alkali, and many storage containers are required for mass production, and inert gas needs to be introduced, which is inconvenient to operate and is not conducive to the production of containers. turnover

[0010] The method disclosed in the Chinese Patent Publication No. CN101229226A is to infiltrate the Danshen slices, extract them with water, and combine the extracts, keep the extracts at 70-100°C for 8-36 hours, and extract the macromolecular phenolic acids in the water extracts of Danshen It is transformed into relatively stable Danshensu under the action of continuous high temperature. The main disadvantage of this method is that the water extract of Salvia Miltiorrhiza is relatively large in volume, and it takes a long time to keep warm at high temperature. Mass production is not conducive to container turnover, high energy consumption, and high production costs.

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