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Blood plasma product for clinical transfusion and preparation method thereof

A technology for plasma and products, which is applied in the field of clinical blood transfusion plasma products and their preparation, and achieves the effect of wide application prospect and important therapeutic effect.

Inactive Publication Date: 2011-04-13
UNION STEMCELL & GENE ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, my country's voluntary blood donation has made great progress, but on the whole, there is still a large gap between my country's blood demand and supply. The annual blood consumption is nearly 1,000 tons, and voluntary blood donation can only meet less than 30% of the total. Blood consumption

Method used

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Embodiment Construction

[0012] Below in conjunction with specific embodiment the present invention is described in further detail:

[0013] The plasma product for clinical blood transfusion of the present invention is prepared from umbilical cord blood.

[0014] The preparation method of the plasma product for clinical blood transfusion comprises the following steps:

[0015] (1) Collect the umbilical cord blood of the discarded placental umbilical cord of the full-term delivery baby, centrifuge, and remove the nucleated cells;

[0016] (2) remove the obtained plasma and carry out ABO and Rh blood type detection, blood cell and plasma component determination, pathogenic microorganism immune detection and bacterial culture;

[0017] (3) The qualified plasma is added with an appropriate amount of protective agent, spin-frozen at -35°C, and after 2 hours, freeze-dried at 35°C-37°C within 18-20 hours to obtain a freeze-dried umbilical cord plasma preparation.

[0018] The blood transfusion includes gen...

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Abstract

The invention discloses a blood plasma product for clinical transfusion and a preparation method thereof. The blood plasma product is prepared from cord blood. The preparation method is as follows: the cord blood in placeta umbilic, which is wasted from a term birth infant, is collected and is centrifuged, and nucleated cells are removed; ABO and Rh blood type detection, blood cell and blood plasma component measurement, pathogenic microorganism immunoassay and germiculture are carried out on the obtained blood plasma without the nucleated cells; and qualified blood plasma is detected, a proper amount of protective agent is added, spin-freeze is carried out at the temperature of minus 35 DEG C for 2 hours, and then freeze-drying is carried out at the temperature of 35 DEG C-37 DEG C within 18-20 hours to obtain the freeze-dried cord blood plasma product. The transfusion comprises common clinical transfusion and transfusion in the aspects of malignant tumor subject to chemo-treatment / radiation treatment and poor hematopoiesis diseases caused by aplastic anemia. The cord blood is a special transfusion resource with important treatment function and also a source of important candidate stem cells.

Description

technical field [0001] The invention relates to a plasma product and a preparation method thereof, in particular to a plasma product derived from umbilical cord blood for clinical blood transfusion and a preparation method thereof. Background technique [0002] As we all know, blood is an indispensable substance to save the lives of some critically ill patients. In recent years, my country's voluntary blood donation has made great progress, but on the whole, there is still a large gap between my country's blood demand and supply. The annual blood consumption is nearly 1,000 tons, and voluntary blood donation can only meet less than 30% of the total. Use blood. Blood shortages occur from time to time, and they still need to be imported to meet clinical needs. [0003] Umbilical cord blood is the blood that remains in the umbilical cord and placenta after the umbilical cord is cut off. Umbilical cord blood has become an important source of hematopoietic stem cells for clinic...

Claims

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Application Information

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IPC IPC(8): A61K35/14A61P7/08A61K35/51
Inventor 侯士芳张宇光陈勇范雯林琳
Owner UNION STEMCELL & GENE ENG
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