13 results about "Plasma products" patented technology

The present invention relates to systems and methods for optimizing plasma collection volume. A plasma withdrawal system and a method for operating a plasma withdrawal system are provided by which the volume / weight of the anticoagulated plasma collected is optimized. In one example, a nomogram is provided that utilizes the donor hematocrit to calculate the volume / weight of raw plasma within a plasma product having a maximum volume allowed by the FDA nomogram. In a plasma withdrawal process having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the increasing hematocrit of the donor, resulting in a greater total volume of plasma product to be collected during the plasma withdrawal process.

A processing device includes a pump system, a valve system, a centrifuge, and a controller. A fluid flow circuit is mounted to the device to execute a procedure in which whole blood is processed into a red blood cell product, a plasma product, and a platelet concentrate product. The blood is first separated into red blood cells, buffy coat, and plasma using the centrifuge, with the red blood cells and plasma being removed from the centrifuge, while the buffy coat remains in the centrifuge. The fluid remaining in the centrifuge is circulated through the centrifuge to form a homogenous mixture. Once the mixture is formed, it is separated in the centrifuge into platelet concentrate and red blood cells. A platelet product is then collected by using whole blood or previously collected red blood cells to push the platelet concentrate from the centrifuge to a collection container.

Methods of preparing therapeutic blood products from merged plasma donors are described. Therapeutic blood products include, for example, plasma, plasma proteins, and plasma fractions with improved safety by reducing the concentration of donor autoantibodies against Fc [epsilon] RI [beta] or eliminating such antibodies.

A method for preparing therapeutic blood products from pooled plasma donors is provided. The therapeutic blood products include, for example, plasma, plasma proteins, and plasma fractions, in which safety is improved by reducing or eliminating the concentration of donor autoantibodies against FcεRIβ.

The utility model belongs to the technical field of plasma product equipment, and particularly relates to a drainage cut-off device for a siphonage method. Comprising a driving device and siphons, the driving device comprises a rear mounting plate frame, a pressing plate mounting box, a pressing plate positioning block, a movable pressing plate set, a cam shaft, a fixed cut-off plate, a front mounting plate, a cut-off door, a movable cut-off plate, a lock rod, an electric push rod, a servo motor and a gear set. The drainage cut-off device for the siphoning method is compact and small in structure, can be used for rapidly and simply achieving automatic siphoning drainage cut-off operation, fully liberates manpower, is used for achieving automation of the siphoning method cryoprecipitation blood coagulation factor preparation process and avoiding direct contact between an operator and a blood bag in the siphoning operation process, and improves the operation efficiency. The isolation effect is enhanced, and the production safety is improved.

The invention relates to a system and a method for optimizing plasma collection volume. A plasma retrieval system and a method for operating a plasma retrieval system are provided by which the volume / weight of collected anticoagulant plasma is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume / weight of raw plasma within a plasma product having a maximum volume allowed by the FDA nomogram. In a plasma extraction process having a plurality of collection phases, after which a re-infusion cycle, in which concentrated red blood cells are returned to the donor, the volume of the plasma product to be collected is calculated before each collection cycle begins to account for an increased hematocrit of the donor, and the volume of the plasma product to be collected is calculated before each collection cycle begins. Thus, the total volume of the plasma product to be collected during the plasma extraction process is larger.

The invention provides a chyloplasma recovery treatment method, which comprises the following steps: modifying kaolin by using alkali and acid substances in sequence, then filtering the chyloplasma by using the modified kaolin and diatomite in sequence, and adopting a filter with a multi-layer gradient structure when the chyloplasma is treated by using the diatomite. According to the technical scheme, cholesterol and triglyceride in chylous plasma are remarkably reduced, and a plasma product with low turbidity is obtained.

The present application belongs to the technical field of plasma product processing equipment, and particularly relates to a compact dry-wet dual-purpose plasma thawing instrument. The compact dry-wet dual-purpose plasma thawing instrument comprises a shell, a thawing assembly and a shaking driving assembly arranged in the shell. The shell comprises a cover at the top and a bottom plate at the bottom. The thawing assembly comprises a water tank, a thawing water tank and a circulating water pump. The water tank is fixed on the bottom plate. A backwater tank is arranged above the front side of the thawing water tank. The shaking driving assembly comprises a mounting plate, a driving motor, an eccentric wheel, a connecting rod, a linear guide rail sliding block pair and a movable support. The present application optimizes the internal structure design of the product, effectively compresses the number of various supporting and fixing structures, effectively utilizes the internal installation space, shortens the length of the internal circulation system pipeline path, improves the system reaction efficiency, has lower production and preparation cost, smaller volume and mass, and smaller installation and use space, and can flexibly meet the needs of small and medium-sized primary medical or production systems.

The application provides a chylomicron plasma recovery treatment method, in which kaolin is modified by alkali and acid substances in sequence, and then the modified kaolin and diatomite are used to filter chylomicron plasma in sequence, and a filter with a multilayer gradient structure is used when the diatomite is used to treat chylomicron plasma; by the technical scheme, the cholesterol and triglyceride in the chylomicron plasma are significantly reduced, and a plasma product with low turbidity is obtained.

A system and method for collecting plasma comprises a control circuit configured to control operation of the system, the control circuit configured to receive one or more donor parameters. The control circuit estimates a physiological fluid amount of the donor based at least in part on the one or more donor parameters and calculates a target amount of plasma product comprising raw plasma and anticoagulant by multiplying a prestored constant by the estimated physiological fluid amount. The control circuit controls the system to operate draw and return phases to process whole blood into plasma product until a measured amount of plasma product in the collection container meets the target amount of plasma product.

The present invention relates to a transportable, containerized, modular and expandable blood facility, namely a blood collection, blood processing and / or spray drying facility. The inventive self-contained portable plasma facility can be transported anywhere in the world and set up to provide a life-saving plasma product. The facility and associated spray drying equipment can be transported by helicopter, plane, truck, train or ship. Once set up, the facility can make spray dried plasma on demand, stored in various temperatures and can be ready for transfusion in just minutes after hydration. The inventive blood processing facility for housing a spray drying system includes the spray drying disposable device and, spray drying apparatus, and / or finishing apparatus. The facility further includes an electrical package, a Clean Dry Air (CDA) package to provide clean dry air to the facility, and an exhaust package to remove humid air generated by the spray drying apparatus.

The utility model belongs to the field of plasma product processing equipment, and particularly relates to a shunting water circulation device for thawing plasma. Comprising an unfreezing tank, a circulating water tank, a water supply pump, a circulating pump, a heat exchanger and a refrigerator, the unfreezing tank comprises a main tank body with a top opening, and a water supply splitter plate and a water return splitter plate positioned on the inner side of the main tank body; the circulating water tank is located below the unfreezing tank, a water tank water supply hole and a water tank water return hole are formed in the side wall of the side, close to the unfreezing tank, of the circulating water tank, and the refrigerator is connected to the cold side of the heat exchanger. According to the shunting water circulation device for plasma unfreezing, a stable unfreezing environment is created by utilizing a circulation loop mainly through the shunting channel and the water tank structure, so that continuous constant-temperature unfreezing of a frozen plasma bag is facilitated.

The application discloses a kind of detection method and system for plasma product species and concentration, belong to plasma technical field, comprising: based on the real-time temperature when generating plasma is collected, obtain the spatial temperature distribution diagram in different time plasma reaction cavity inside under different discharge voltages;By simulating the discharge process in plasma reaction cavity, the species and particle number density of main plasma product under short time scale are obtained;Based on temperature distribution diagram and discharge area when generating plasma, according to particle number density, obtain the generation rate of each product inside plasma reaction cavity and the concentration change of substance under long time scale.The application realizes plasma product mode discrimination and product concentration detection under long time scale, the application comprehensively considers the influence of real-time discharge area, temperature field on product concentration calculation, detection process is simple and convenient, provides guarantee for the efficient operation of plasma in industrial application.