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Terazosin pellicle and preparation method thereof

A technology of terazosin and film preparation, which is applied in the field of terazosin instant film preparation technology, can solve the problems such as the inability of dropping pills to release medicine more quickly, and the unsatisfactory results.

Inactive Publication Date: 2013-06-05
HEBEI AOXING GROUP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] According to the above description, it can be seen that the terazosin hydrochloride dropping pills are compared with tablets and capsules, although they have the characteristics of fast disintegration and dissolution, high dissolution rate and high dissolution rate, but the terazosin hydrochloride dropping pills itself The characteristics and dissolution characteristics determine that the dropping pills cannot release the drug more quickly
Therefore, although it is acceptable to adopt the dosage form of dropping pills to accelerate drug release, the result is still not quite satisfactory.

Method used

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  • Terazosin pellicle and preparation method thereof
  • Terazosin pellicle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 (prescription quantity 1000)

[0024] Terazosin Hydrochloride 1g

[0025] Hypromellose 10g

[0026] Glycerin 1g

[0027] Sunset Yellow (2%) 0.5ml

[0028] Sodium Benzoate 10mg

[0029] Stevia 50mg

[0030] Purified water 100ml

[0031] Accurately weigh 1 g of terazosin hydrochloride, add it to 100 ml of purified water, heat to dissolve, add hypromellose to swell, after the swelling is uniform, add glycerin, sunset yellow, sodium benzoate, stevia, and stir evenly. Vacuumize or sonicate the prepared solution to remove air bubbles. Adjust the position of the film spreader and the steel plate or glass plate to make it horizontal, then place the film liquid on the steel plate or glass plate, apply the film slowly and evenly, and then place it in a horizontal position to dry in the shade. Semi-finished products are tested, assayed, film cut, packaged, and set aside.

Embodiment 2

[0032] Embodiment 2 (prescription quantity 1000)

[0033] Terazosin Hydrochloride 1g

[0034]Hypromellose 10g

[0035] Glycerin 1g

[0036] Polyoxyethylene hydrogenated castor oil 1g

[0037] Brilliant Blue (2%) 0.5ml

[0038] Sodium Benzoate 10mg

[0039] Stevia 50mg

[0040] Purified water 100ml

[0041] Accurately weigh 1g of terazosin hydrochloride, add it to 100ml of purified water, heat to dissolve, add hypromellose to swell, and after the swelling is uniform, add glycerin, polyoxyethylene hydrogenated castor oil, brilliant blue, sodium benzoate, stevia, Stir well. Vacuumize or sonicate the prepared solution to remove air bubbles. Adjust the position of the film applicator and the steel plate or glass plate to make it horizontal, then place the film solution on the steel plate or glass plate, apply the film slowly and evenly, and then place it in a horizontal position to dry in the shade. Semi-finished products are tested, assayed, film cut, packaged, and set as...

Embodiment 3

[0042] Embodiment 3 (prescription quantity 1000)

[0043] Terazosin Hydrochloride 1g

[0044] Kollicoat IR 15g

[0045] Glycerin 1g

[0046] Poloxamer 1g

[0047] Sunset Yellow (2%) 0.5ml

[0048] Sodium Benzoate 10mg

[0049] Stevia 50mg

[0050] Purified water 100ml

[0051] Precisely weigh 1 g of terazosin hydrochloride, add it to 100 ml of purified water, warm to dissolve, add Kollicoat IR to dissolve, then add glycerin, poloxamer, sunset yellow, sodium benzoate, stevia, and stir well. Vacuumize or sonicate the prepared solution to remove air bubbles. Adjust the position of the film applicator and the steel plate or glass plate to make it horizontal, then place the film solution on the steel plate or glass plate, apply the film slowly and evenly, and then place it in a horizontal position to dry in the shade. Semi-finished products are tested, assayed, film cut, packaged, and set aside.

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Abstract

The pellicle is prepared from terazosin, film-forming materials, water, plasticizers, surfactants, preservatives, colorants, and flavourings; wherein terazosin is dispersed uniformly in the pellicle in molecular state, amorphous form, or micellar form. The pellicle dissolves rapidly upon meeting water, so the terazosin pellicle has the advantages of quick effect and high bioavailability.

Description

technical field [0001] The invention relates to a terazosin instant film preparation process, in which terazosin is evenly dispersed in the water instant polymer film material in the form of molecular state, amorphous, micelles or micelles, and the prepared film is met It dissolves quickly in water and has the advantages of quick effect. Background technique [0002] Terazosin is a selective α-adrenoceptor blocker that selectively blocks adrenal α on smooth muscle of the bladder neck, prostate, and urethra 1 -Receptors, relax the smooth muscle without affecting the contractility of the bladder wall, so as to relieve the dynamic obstruction of the bladder outlet, and quickly relieve the symptoms of urinary obstruction, thereby improving the urinary flow and clinical symptoms of patients with benign prostatic hyperplasia. [0003] Terazosin can also selectively inhibit the post-synaptic membrane of sympathetic nerve terminal α 1 -Receptors, relax vascular smooth muscle, impr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/517A61K47/38A61K47/32A61K47/36A61K47/42A61K47/34A61K47/44A61P9/12A61P13/08
Inventor 刘福利杨丽英赵学刚张琳宇滑千里王乃浩
Owner HEBEI AOXING GROUP PHARMA