Tumor treating system fusing phased high intensity focused ultrasound (PHIFU) and magnetic resonance

Abstract

The invention relates to a tumor treating system fusing phased high intensity focused ultrasound (PHIFU) and magnetic resonance. The tumor treating system is composed of a PHIFU treating control unit, a multichannel phase control signal generator, a multichannel voltage controller, a multichannel resonant power amplification unit, a multi-array-element PHIFU energy converter, an MRI (magnetic resonance imaging) scanning module and an MRI temperature processing module, wherein, the phase and amplitude of an excitation signal are calculated by the PHIFU treating control unit according to a treatment plan; a high-power excitation signal generated by the multichannel phase-control signal generator, the multichannel voltage controller and the multichannel resonant power amplification unit drives the PHIFU energy converter; the MRI scanning module is controlled by the PHIFU treating control unit to scan a target region; the acquired image is processed by the MRI temperature processing module to obtain real-time three-dimensional temperature information; and the heating strategy is adjusted by the PHIFU treating control unit according to the feedback temperature information. The system provided by the invention has the advantage of realizing the safe and effective treatment of the tumor by combining PHIFU electron focus, heating advantages of multiple focuses and the advantages of MRI accurate positioning and temperature real-time accurate measurement.

Description

Technical field [0001] The invention relates to an ultrasound tumor treatment system, in particular to a system that combines the advantages of Magnetic Resonance Imaging-MRI and Phased High Intensity Focused Ultrasound-PHIFU to achieve non-destructive treatment of tumors The system belongs to the field of medical device technology. Background technique [0002] Globally, the incidence of tumors remains high, and the cure rate is low. Surgical resection is currently a commonly used method in tumor treatment, but for advanced patients, surgery is too traumatic for the patient, so it is non-invasive and minimally invasive Tumor treatment methods are particularly important. High Intensity Focused Ultrasound (HIFU) is a green, non-invasive, safe and effective tumor treatment method. HIFU converges high-intensity ultrasound to human tumor tissues and generates high heat in a short period of time, causing tissue degeneration and necrosis, thereby killing tumor cells. HIFU treatment ...

AI Technical Summary

Problems solved by technology

The biggest problem with this type of equipment and treatment methods is that the tissue temperature cannot be monitored during HIFU treatment, which can easily cause damage to normal tissues, so there is a big safety problem

[0006] Chinese patent CN1903390A proposes an MRI-guided high-intensity focused ultrasound system. The ultrasonic treatment part of the system is composed of a traditional single-array element transducer, which can only form a single focus. During the treatment process, the transducer must be controlled by mechanical displacement. Single-focus scanning is realized, the treatment mode is single, not flexible enough, the treatment efficiency is low, and the bone barrier cannot be bypassed

The single-array element HIFU transducer needs to move mechanically, so it is easy to introduce serious electromagnetic interference in MRI. During the HIFU heating process, the real-time measurement of the target tissue temperature is only two-dimensional information, and the temperature measurement information is not added to the automatic feedback control system.

Chinese patent CN2853097Y proposes a HIFU treatment system based on open MRI guidance, which is based on a low-field MRI system and a single-array HIFU transducer. Although this system design is more convenient, image guidance is better than traditional B-ultrasound. Guidance is accurate, but the temperature measurement of the system has problems such as large drift, not accurate enough and fast, so it is not a good solution

This system is only suitable for the treatment of uterine fibroids. In order to avoid interference with MRI imaging during the heating process of PHIFU, the output energy of the transducer is reduced, which leads to a long time for a single focus to reach the temperature required for treatment, and the treatment efficiency is low. The system is modified for diagnostic MRI, and the cost is high

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