71 results about "Hyperintensity" patented technology

A high-intensity focused ultrasound ablation of tissue using minimally invasive medical procedures is provided.

A novel contrast mechanism for imaging blood flow using magneto-motive optical Doppler tomography (MM-ODT), Optical Coherence Tomography, and Ultrasound. MM-ODT, OCT, and ultrasound combined with an externally applied temporally oscillating high-strength magnetic field detects erythrocytes moving according to the field gradient.

The invention disclosed a high-intensity focused ultrasound thermal ablation apparatus having integrated temperature estimation and elastography for thermal lesion determination and the method thereof, using the different power to burn by the same focused ultrasound transducer, and then using the apparatus to measure the temperature and elasticity estimating by the relevant analysis method.

An application of a high-intensity focused ultrasound system to treatment of essential hypertension. A treatment process includes: conducting ultrasonic positioning measurement on both sides of perirenal fat tissue of a patient, setting a therapeutic window and parameters of the system, and setting corresponding power parameter of the system, so as to make local temperature of the tissue during treatment reach 40-70° C., wherein treatment portions are both sides, and treatment scope is one third to all of the whole tissue; starting the system to treat one side of the tissue according to the set parameters and then the other. By treating a secondary center for regulating the activity of a whole-body sympathetic system, the activity of the whole-body sympathetic system can be reduced, so that the blood pressure level of the patient can be reduced, and fewer kinds and smaller dosage of antihypertensive drugs can be taken or ceased.

The invention relates to a tumor treating system fusing phased high intensity focused ultrasound (PHIFU) and magnetic resonance. The tumor treating system is composed of a PHIFU treating control unit, a multichannel phase control signal generator, a multichannel voltage controller, a multichannel resonant power amplification unit, a multi-array-element PHIFU energy converter, an MRI (magnetic resonance imaging) scanning module and an MRI temperature processing module, wherein, the phase and amplitude of an excitation signal are calculated by the PHIFU treating control unit according to a treatment plan; a high-power excitation signal generated by the multichannel phase-control signal generator, the multichannel voltage controller and the multichannel resonant power amplification unit drives the PHIFU energy converter; the MRI scanning module is controlled by the PHIFU treating control unit to scan a target region; the acquired image is processed by the MRI temperature processing module to obtain real-time three-dimensional temperature information; and the heating strategy is adjusted by the PHIFU treating control unit according to the feedback temperature information. The system provided by the invention has the advantage of realizing the safe and effective treatment of the tumor by combining PHIFU electron focus, heating advantages of multiple focuses and the advantages of MRI accurate positioning and temperature real-time accurate measurement.

A method for treating a scar on a skin surface of a subject is provided. A subject is identified as having a skin surface with scar tissue. In response to identifying the subject as having the scar tissue, a housing comprising at least one acoustic transducer is placed on the skin surface with the scar tissue and the acoustic transducer is activated to apply high intensity focused ultrasound energy to a portion of the scar tissue. Other embodiments are also described.

A medical apparatus (600, 700, 800, 900) comprising a high intensity focused ultrasound system (602) configured for generating focused ultrasonic energy (612) for sonicating within a target volume (620) of a subject (601). The high intensity focused ultrasound comprises an ultrasonic transducer (606) with a controllable focus (618). The apparatus further comprises a memory (634) containing machine executable for controlling the medical apparatus and a processor (628) for executing the instructions. Execution of the instructions causes the processor to cause (100, 200, 300, 400, 502) ultrasonic cavitations at multiple cavitation locations (622, 1002) within the target volume using the high intensity focused ultrasound system. Execution of the instructions further cause the processor to sonicate (102, 206, 306, 402, 504) multiple sonication locations (1004) within the target volume using the high intensity focused ultrasound system. The multiple sonication locations and the multiple cavitation locations are targeted by adjusting the controllable focus.

The invention provides an optical tweezers control method based on hollow light dimension adjustment and an optical tweezers control device based on hollow light dimension adjustment. The optical tweezers control method comprises the steps that one modulated laser beam and another modulated laser beam are incident to a nonlinear medium and hollow light is acquired; the hollow light is expanded andcollimated and then divided into two beams of child hollow light through a third polarizing beam splitting cube; the two beams of child hollow light is the first child hollow light and the second child hollow light; the first child hollow light is incident to a first imaging device; the second child hollow light is converged to a sample pool through a fourth focusing lens, wherein sample participles are sprayed in the sample pool and the sample participles are captured at the light trap position by the second child hollow light; and movement of the sample participles is adjusted by adjustingthe light intensity of the modulated laser beams. The phase of the modulated laser beams is changed by the modulated laser beams so that the modulated laser beam far field light intensity distributionpresents in a way that the middle intensity is zero and the surrounding is a circle of high intensity laser, and then three-dimensional operation is performed on the light absorbing particles in theair by using the dimension adjustable hollow light beams.

Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device that employs high intensity focused ultrasound. The high intensity focused ultrasound may be used for application of energy to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. The ultrasound transducer for delivering the energy may be located remotely from the desired treatment area. In particular embodiments, an ultrasound transducer may apply energy at one or more focal zones or focal points that target renal nerves.

A magnetic resonance imaging white matter hyperintensities region recognizing method and system are disclosed herein. The white matter hyperintensities region recognizing method includes receiving and storing a FLAIR MRI image, a spin-lattice relaxation time weighted MRI image, and a diffusion weighted MRI image. Registration and fusion are preformed, and a white matter mask is determined. An intersection image of the FLAIR MRI image and the white matter mask is taken, a first region is determined after normalizing the intersection image, a cerebral infarct region is removed from the first image through the diffusion weighted MRI image, and then a determination is made as to whether to remove a remaining region in order to form a white matter hyperintensities region in the FLAIR MRI image.

The present invention relates to a sound intensity and acoustical power measurement method of the high-strength focused ultrasound. The sound intensity and acoustical power measurement method of the present invention is characterized by selecting two mutually parallel first and second planes in a pre-focusing area of the high-strength focused ultrasound to measure, and using a PC to control a hydrophone to scan the sound pressure data on the first plane, and then using a servo motor to control the hydrophone to move along a Z direction accurately, repeating the above control and acquisition processes, and obtaining the sound pressure data on the second plane. The sound intensity and acoustical power measurement method of the high-strength focused ultrasound of the present invention has the remarkable characteristics of being simple and convenient to implement, efficient and accurate to calculate, etc., avoids measuring in a focusing area, can protect a sensor furthest, can obtain a plurality of parameters, such as the sound intensity distribution, etc., while obtaining the acoustical power, facilitates evaluating the performances of a focusing transducer comprehensively, and is suitable for measuring the radiation acoustical powers of various focusing transducers.

The invention provides an end sensitive fiber bragg grating high-intensity focused ultrasound sensor which has the grating region length L2, and a central position of a grating region is positioned within a range which covers a distance of L1 away from a single-mode fiber end. The end sensitive fiber bragg grating high-intensity focused ultrasound sensor provided by the invention has higher sound pressure sensitivity than that of a luminous intensity type fiber optic hydrophone which is based on a Fresnel end face reflection principle, is of a full quartz structure, adopts an end sensitive structure and has strong sound pressure bearing capability; compared with a lateral sensitive fiber bragg grating high-intensity focused ultrasound sensor, the end sensitive fiber bragg grating high-intensity focused ultrasound sensor is easy to clamp, is prevented from being damaged by shock wave and can overcome the disturbance of ultrasonic standing wave; different types of membranes are plated on the end sensitive fiber bragg grating high-intensity focused ultrasound sensor, so that the sound pressure resistance or the sound pressure sensitivity can be increased; the end sensitive fiber bragg grating high-intensity focused ultrasound sensor which is added into an annular tube sheath can be prevented from being damaged by the cavitation effect of a sound field; and the end sensitive fiber bragg grating high-intensity focused ultrasound sensor system is simple, and can satisfy requirements on MHz ultrasound measurement.

The invention relates to a method for splicing tunnel images without identification. A high-strength linear laser is adopted for assisting in marking, the position of imaging rays of laser rays on a camera is identified through an image detection algorithm, and the shot tunnel images are spliced and fused through the marked position. Transition of the image fusion edges is made even in a mode for averaging pixels with parameters near the laser rays.

A medical apparatus (300, 400, 500) comprises a high intensity focused ultrasound system (322) configured for for sonicating a target volume (340) of a subject (318). The medical apparatus further comprises a magnetic resonance imaging system (302) for acquiring magnetic resonance data (356, 358, 360, 368, 374) from an imaging zone (308). The treatment volume is within the imaging zone. The medical apparatus further comprises a memory (352) containing machine executable,a control module (382, 402) for controlling the sonication of the target volume using the magnetic resonance data as a control parameter, and a processor (346). Execution of the instructions causes the processor to repeatedly acquire (102, 202) magnetic resonance data in real time using the magnetic resonance imaging system and control (104, 206) sonication of the target volume by the high intensity focused ultra-sound system in real time using the sonication control module and the magnetic resonance data.

A device for thermal keratoplasty, the device comprising a plurality of ultrasonic transducers for emitting ultrasound waves, wherein the ultrasound waves of at least one of the transducers is focused on a corresponding area of the cornea in order to heat these area and cause collagen shrinkage and at least one of the transducers is capable of receiving ultrasound waves for ocular imaging.

The invention discloses a radiation device and a radiation inspection system. The radiation device comprises a scanning device and an attenuating device, wherein the scanning device is used for emitting scanning ray beams to a detection area, the attenuating device has multiple work modes, under the different work modes, intensities of the different-part scanning ray beams emitted by the scanning device are attenuated by the attenuating device, and an absorption close rate of the scanning ray beams after attenuation incident to a corresponding part of a detected object of a detection area is made to be lower than preset threshold. The radiation device is advantaged in that on the condition a detection avoidance portion is guaranteed not to subject to high strength radiation, and normal detection on a non-detection avoidance portion of the detected object is not influenced.

The invention discloses a movement scanning device of a high-intensity focused ultrasonic treatment system. The movement scanning device comprises a frame, a movement assembly, an ultrasonic scanning assembly and a scanning assembly supporting frame; the ultrasonic scanning assembly is arranged on the scanning assembly supporting frame; the movement assembly comprises an X axis assembly, a Y axis assembly, a Z axis assembly, an X axis swing assembly and a Y axis swing assembly. According to the movement scanning device of the high-intensity focused ultrasonic treatment system, the level progressive linear motion of the X axis, the Y axis and the Z axis and the degrees of freedom of swinging around the X axis and the Y axis are adopted and accordingly the integral treatment system can be compact, low in size and light in weight due to the reasonable layout design; the size is reduced, the height of the movement device is reduced, and accordingly the height of the treatment head can be reduced and accordingly the bed surface is lowered, a patient can get on and off a bed board conveniently, the stronger sense of security is brought to the patient, and meanwhile the corresponding operation of a doctor can be convenient; meanwhile a B type ultrasound probe is combined to rotate around the treatment head in a lifting mode and accordingly the monitoring on an affected region of the patient is comprehensive, a monitoring image in the treatment process can be clear, and accordingly the treatment effect is ensured.

A system and method for MR imaging is disclosed. The method causes an RF coil assembly and plurality of gradient coils to apply a fast spin echo (FSE) pulse sequence comprising a preparation segment and a plurality of refocusing segments. The FSE pulse sequence generates a pair of echoes is generated in each of the plurality of refocusing segments that comprises a first echo generated by magnetization pathways having an even number of phase inversions and a second echo generated by magnetization pathways having an even number of phase inversions. MR signals are acquired from the first echo and the second echo and an image of at least a portion of a subject of interest is reconstructed from the acquired MR signals.

The present invention relates to an algorithm capable of rapidly calculating and simulating a three-dimensional temperature field caused by high-intensity focused ultrasound at biological soft tissues, and specifically relates to a high-intensity focused ultrasound three-dimensional temperature field simulation algorithm based on Gauss function convolution. The algorithm comprises the following steps of (1) calculating a sound field at a high-intensity focused ultrasound focus by utilization of the sound radiation principle; (2) performing convolution operation on an original temperature graph generated by the sound field on the biological tissues and the Gauss function; and (3) calculating a time-dependent three-dimensional temperature field at the ultrasound focus. Operand of the Gauss function is little, operation speed is fast, and the time-dependent three-dimensional temperature field caused by the high-intensity focused ultrasound is real-time temperature simulation. The algorithm is applied to real-time temperature monitoring during a high-intensity focused ultrasound tumor ablation treatment process, waste heat during the ablation process and a heat source position can be controlled, maximum damage to tumors during the treatment process is optimized, and damage to peripheral healthy cells is prevented.

The invention is disclosed to design a real-time pulse / echo system to perform 1-D real-time temperature measurement and integrate in the high-intensity focused ultrasound system. In the invention, a modified echo-time shifting algorithm is developed to calculate the corresponding phase shift from echo signal, which correlates with the instantaneous temperature change during heating process.

The invention provides a method for measuring a fetal corpus callosum volume by using magnetic resonance imaging, and a magnetic resonance imaging apparatus. The method comprises the following steps:acquiring a positioning image of a to-be-detected fetus through magnetic resonance imaging; determining a detection area P according to the position of fetal corpus callosum in the positioning image,wherein the detection area P comprises the fetal corpus callosum; carrying out magnetic resonance scanning on the detection area to obtain a diffusion weighted image of the detection area, wherein a gradient direction during the magnetic resonance scanning only needs to be applied to a direction parallel to the extension direction of the fiber bundles of the corpus callosum; intercepting a fetal head image in the diffusion weighted image; applying a preset threshold to the fetal head image to obtain high signals with brightness greater than a threshold in the image; and carrying out bunching processing on the high signals, taking the maximum bunch in the high signals as corpus callosum, calculating the sum of the sizes of voxels related to the high signal of the maximum bunch, and taking the sum as the volume of the corpus callosum.

The present invention relates to a probe that comprises a piezoelectric therapy transducer having an acoustic axis BB′, and an imaging transducer having an imaging plane, in which the therapy transducer and imaging transducer are mounted in a head which is itself connected to a guide. More particularly, the therapy transducer is in a form of a truncated cup and has a spherical concave front face for emitting ultrasonic waves focused on a focal point, a rear surface and the therapy transducer is truncated alone two parallel lanes such that a length d1, a width t and a longitudinal direction are provided; the therapy transducer is a 1D annular phased array transducer and the imaging transducer is a multiplane transducer having a rotation axis corresponding to the acoustic axis of the therapy transducer whereby the focal point of the therapy transducer is comprised in the imaging plane of the imaging transducer, said imaging transducer being fixed to the therapy transducer

The invention provides a filtering based imaging system dynamic range extension method, is particularly suitable for obtaining a big dynamic image in a superfast high-intensity light-emitting processand is simple and clear in system structure and low in implementation cost. The image sensor in the imaging system adopted by the method is a color image sensor or a grey image sensor covered with a multi-color coating film or a multi-color lens. The method comprises the following steps of selectively filtering a wide-spectrum visible image of an imaging scene into an approximate monochromatic light image by utilizing a spectrum selection function of a narrowband filter; obtaining multiple sub-images with different attenuation coefficients through multi-color filtering, wherein the sub-imageswith the relatively small attenuation coefficients can obtain scene images with relatively low brightness, and the sub-images with relatively big attenuation coefficients can obtain scene images withrelatively high brightness; and obtaining a high dynamic range image with high resolution through sub-image interpolation calculation.

The invention relates to a multipurpose contrast agent applied to ultrasonography / magnetic resonance imaging (US / MRI) guidance synergistic high-intensity focused ultrasound ablation and a preparation method for the multipurpose contrast agent and belongs to the field of ultrasonic medicine. The multipurpose contrast agent is a polymer microsphere with a core-shell structure. A shell membrane consists of lactic acid / poly lactic-co-glycolic acid (PLGA) and magnetic ferroferric oxide (Fe3O4) nano-particles in weight ratio of (30-70):1 in material, wherein the magnetic Fe3O4 nano-particles are inlaid onto the shell membrane. Double distilled water is coated on the core of the contrast agent. By taking the inorganic superparamagnetic ferroferric oxide nano-particles and the organic high polymer material lactic acid / PLGA as membrane-forming materials and by combining the respective advantages of the two materials, US in-vivo displaying and MRI in-vivo displaying can be performed on tumorigenesis and tumor progression by the multipurpose contrast agent. US / MRI monitoring synergistic high-intensity focused ultrasound ablation treatment can also be performed, and thereby, a solid foundation is laid for early discovery, early diagnosis and early treatment on tumors.

The invention discloses a recombinant virus. A vesicular stomatitis virus serves as a carrier, and an encoded antibody CVB3 structural protein VP1 gene is inserted between glycoprotein G and polymerase protein L of the vesicular stomatitis virus. The invention also provides a preparation method of the recombinant virus. According to the method, the recombinant virus is obtained by means of transfecting BHK21 cells via five plasmids: pP, pL, pXN2-VP1, pVSVG and pN. The invention also provides a vaccine which contains an effective dose of vaccine contains. A person can be vaccinated with the vaccine in a mucosa part by means of nasally dripping or orally taking, or through genital tracts, and the like. The technical problems is as follows: the conventional vaccine in the prior art can not effectively induce high-strength mucosa immune response, and the antibody can not effectively stay at a local mucosa part and consequently is insufficiently taken by APCs (Antigen Presenting Cells) are solved. The recombinant virus is capable of effectively enhancing CVB3 specific serum and local mucosa part antibody response, and remarkably strengthening the killing capability to local specific CD8T cells of whole-body and intestinal mucosa.

A method for reducing magnetic resonance temperature measurement errors, which is used for the high-intensity focused ultrasound device for monitoring magnetic resonance imaging includes obtaining a magnetic resonance phase diagram as a reference image before the high-intensity focused ultrasound device heats the heating area; obtaining another magnetic resonance phase diagram as a heating image during or after the heating process of the high intensity focused ultrasound device; calculating the temperature changes in the heating area according to said heating image and reference image. The method further includes measuring the magnetic field changes caused by the position changes of the ultrasonic transducer of said high-intensity focused ultrasound device, and then compensating for the temperature changes according to said magnetic field changes. The present invention can significantly reduce the temperature errors caused by the position changes of the ultrasonic transducer.

The invention relates to an HIFU sound field detection system based on a finite element model method. According to the invention, a finite element model method is adopted to simulate sound field distribution characteristics and sound focusing morphological characteristics of an actual HIFU transducer in a three-dimensional space; the relationship between the driving voltage and the sound pressureof the radiation sound field is obtained; a high-precision industrial mechanical arm is adopted to accurately control and measure the hydrophone to carry out rapid scanning work of a spherical sound field in a three-dimensional space of a high-intensity focused sound field; the spherical planning motion path makes up the influence of phase inconsistency and acoustic radiation angle deviation on sound field measurement; the embedded motion control module and the data acquisition module are integrated and are directly connected with the notebook computer; a measurement system is simplified to the maximum extent, a high-precision industrial mechanical arm is used for accurately scanning a spatial sound field and feeding the spatial sound field back to a finite element type for optimization processing, a finite element model can accurately simulate a HIFU transducer radiation sound field, and a reference mode is provided for a measurement test of an ultrasonic source.

A therapeutic apparatus (300, 400, 500) comprising a high intensity focused ultrasound system (302) comprising an ultrasound transducer (306). The ultrasound transducer has an electronically adjustable focus (318). The high intensity focused ultrasound system has a beam deflection zone (322, 608, 704, 1010). The intensity of ultrasound at the electronically adjustable focus divided by the acoustic power emitted is above a predetermined threshold (606, 1008) within the beam deflection zone. The therapeutic apparatus further comprises a processor (328) for controlling the therapeutic apparatus. Execution of machine executable instructions (350, 352, 354) causes the processor to: receive (102, 202) real time medical data (342, 424, 506) descriptive of the location of a moving target (320, 802); adjust (104, 204) the electronically adjustable focus to target the moving target using the real time medical data; and sonicate (106, 206) the moving target when the moving target is within the beam deflection zone.

The present invention relates to a method and a system for the segmentation of white matter hyperintensities (WMHs) present in magnetic resonance brain images, comprising: providing an array of trained convolutional neural networks (CNNs) with a magnetic resonance brain image; determining, for each of the CNNs and for each voxel, the probability that the given voxel corresponds to a pathological hyperintensity; calculating the average of all the probabilities determined for each voxel; comparing the averaged probabilities for each voxel with a threshold; generating an image mask with the voxels that exceed the threshold.