82 results about "High intensity focused" patented technology

In a method for automatically selecting a region of interest covering a heated area, in the context of high intensity focused ultrasonic technology during acquisition of magnetic resonance data, phase data of a scanned area are acquired, and a heated area is identified in the scanned area according to the phase data acquired. An image is reconstructed and displayed, and in the displayed image a region of interest covering the heated area is automatically demarcated according to a predetermined size of said region of interest that covers and is larger than the heated area. The method causes the heated area to be automatically and completely included in the region of interest; and eliminates the instability of a manual selection of the region of interest.

The invention provides a phased array high-intensity focused ultrasonic therapy system which comprises an ultrasonic transmitting device, a signal processing device, a feedback device and a human-computer interaction device. The ultrasonic transmitting device is respectively connected with the signal processing device and the feedback device, and the feedback device is respectively connected with the signal processing device and the human-computer interaction device. The feedback device of the phased array high-intensity focused ultrasonic therapy system can output intensity instructions and frequency instructions to the ultrasonic transmitting device according to a target tissue three-dimensional image, a non-target tissue three-dimensional image and a tissue variable quantity outputted by the signal processing device and a preset tissue variable quantity to control the intensity and the frequency of ultrasonic waves transmitted by the ultrasonic transmitting device to adapt to the intensity needed by therapy or detection, so that target tissues can be damaged, and non-target tissues cannot be damaged in the therapy process.

The invention relates to a multi-channel high precision phase control signal generation device which utilizes a programmable read-only memory to generate a customized special circuit in an FPGA (Filed Programmable Gate Array) circuit through a VHDL (Very High Speed Integrated Circuit Hardware Description Language) language programming. The multi-channel high precision phase control signal generation device comprises a phase shift module, a phase coding module, an address coding module and a plurality of multi-channel gates. By taking a high precision active crystal oscillator as an information source, all multi-channel gates works in parallel to receive phase control signals of a host computer and output square wave signals of a multi-channel special phase. The output square wave signals access resonance of a power amplifier to generate sine wave signals with the same frequency and phase with the traditional output signals and the sine wave signals are used for excitation signals of an ultrasonic transducer array element in a phase control type high intensity focusing ultrasonic treatment system; and the frequency of the crystal oscillator is determined by the resonance frequency and the phase control precision requirements of the ultrasonic transducer array element. The invention dramatically increases the channel amount of the phase control signals and enhances the precision of the phase control signals, thereby satisfying the needs of the high intensity focusing ultrasonic treatment system.

The invention relates to a piezoelectric focusing ultrasonic transducer, which comprises a concave spherical lightening housing (1), a unit focusing energy converter (2), an end cap (3), a gasket (4), a connector base (5) and an insulating connector base (6). The method uses the polyvalent secondary focusing method to geometrical focus with high intensity. The device can produce the high-intensity focusing ultrasonic with prompt high pressure and temperature effect, and has small focus range and large acoustic pressure, and the system is stable, and it can be widely used in the biology, medical treatment, manufacturing and other technique fields.

The invention relates to a measuring system of a high-intensity focusing ultrasonic sound field. The measuring system comprises an intelligent data processing module, a multi-degree of freedom progressive scanning control module, a data acquisition module and a hydrophone, wherein the intelligent data processing module sends a command to the multi-degree of freedom progressive scanning control module to perform intelligent sound field scanning, and acquires corresponding sound field distribution and sound field parameters according to acquired data; the data acquisition module acquires voltage signals sensed by the hydrophone; the multi-degree of freedom progressive scanning control module consists of a three-dimensional step motor controller, a three-dimensional motion device and a hydrophone fixing device; and a sound-absorbing rubber is adhered to the bottom surface of the hydrophone fixing device. The three-dimensional motion device performs the motion modes of inching, increment or synchronous increment and the like according to the command of the three-dimensional step motor controller; and the three-dimensional step motor controller controls multi-shaft simultaneous motion, single-shaft uniform motion or single-shaft variable motion according to the command of the intelligent data processing module. The measuring system can realize quick, accurate, intelligent and graphical ultrasonic sound field measurement.

A system, method and devices for providing improved methods to harden UV-curable coating materials when those coating materials are applied over optical fibers or other optical targets during the manufacturing process is provided. The technology disclosed herein uses LEDs (or low power light bulbs) to create UV power, which is focused with high intensity on the surface of a coated fiber. This is done simultaneously from multiple angles to fully cover the target product over 360 degrees of surface and is then repeated a number of times along the product path to ensure sufficient degree of curing.

A MRI guided high-intensity focused ultrasonic therapy system is composed of a MRI unit including the first therapeutic bed and a high-intensity focused ultrasonic therapy unit having an ultrasonic transducer and a moving-locating mechanism with a supporting rod able to be extended in the gap of said MRI unit during therapy and connected to said ultrasonic transducer.

A nontracking solar concentrator, called the wedge, is given the ability to collect overhead light. This is made possible by a new prism, having the cross section of a cornucopia, that delivers an abundance of bright light into the wedge to create a higher intensity focus.

The invention is a kind of transverter array in high-intensity focusing supersonic tumour treat. The invention is made up of matching layer and piezoelectricity chinaware pieces. The matching layer is a even bowl sound radiating layer, all the piezoelectricity chinaware pieces are stuck on the outer surface of the same matching layer, the piezoelectricity forms the transverter array. The invention has a high focusing sound-intensity ratio and sound speaking feature; the cost is low; the structure is simple, and the stability and the reliability are enhanced.

An equipment for measuring the sound field in a focused region of high-intensity focused ultrasonic field is composed of a supporting frame, a sound-absorbing water tank, a data processor, a pressure-sensitive sensor able to directly measure the sound pressure of high-power high-intensity sound field, 3D movement regulator, 2D rotation regulator, and probe holder. Its advantages are high speed and accuracy and simple operation.

The present invention pertains to the biomedical field, more particularly, the present invention relates to a sound-sensitive agent which has the oxygen carrying function. The sound-sensitive agent is a composition which is composed of the substances with the oxygen carrying function and the sound-sensitive substances. The present invention makes use of the substances with the oxygen carrying function to improve the oxygen content of the target area, strengthen the sonodynamic effect of the sound-sensitive substances and develop the safe and effective sound-sensitive agent. The sound-sensitive agent which has the oxygen carrying function can be used as the sound-sensitive agent during the sonodynamic treatment process and can be used as the synergistic agent during the low-intensity / high-intensity focused / non-focused ultrasound treatment process, so the present invention is applicable to the skin care, obesity, benign and malignant proliferative diseases.

The invention relates to a tumor treating system fusing phased high intensity focused ultrasound (PHIFU) and magnetic resonance. The tumor treating system is composed of a PHIFU treating control unit, a multichannel phase control signal generator, a multichannel voltage controller, a multichannel resonant power amplification unit, a multi-array-element PHIFU energy converter, an MRI (magnetic resonance imaging) scanning module and an MRI temperature processing module, wherein, the phase and amplitude of an excitation signal are calculated by the PHIFU treating control unit according to a treatment plan; a high-power excitation signal generated by the multichannel phase-control signal generator, the multichannel voltage controller and the multichannel resonant power amplification unit drives the PHIFU energy converter; the MRI scanning module is controlled by the PHIFU treating control unit to scan a target region; the acquired image is processed by the MRI temperature processing module to obtain real-time three-dimensional temperature information; and the heating strategy is adjusted by the PHIFU treating control unit according to the feedback temperature information. The system provided by the invention has the advantage of realizing the safe and effective treatment of the tumor by combining PHIFU electron focus, heating advantages of multiple focuses and the advantages of MRI accurate positioning and temperature real-time accurate measurement.

A 3-D locating system for high-intensity focused ultrasonic operation is composed of a 3-D moving bed fixed on the floor, a machine frame arranged at outside of longitudinal central line of the said bed, a C-shaped arm mechanism on the machine frame, and a treating head assemblage containing a set of precise location system and ultrasonography-B imaging mechanism so as to realize functions of monitoring and regulating real-time location while treating.

The invention involves a high-intensity focused ultrasound transducer array which includes a number of its elements, driven device of the element and pallets with a number of holes, each element embed in holes, and each element is connected with a separated driving device, driven devices can make each element focus on different space points. The element points joining treatment can make the multiple scanning treatments, linear scanning treatment or curve scanning treatment. The invention has simple construction and flexible focus position; it is suitable for the treatment of larger regional focus particularly.

A locating and scanning device of focused ultrasound treatment with high intensity is a three-dimensional locating, five-dimensional accurate scanning device in a focused ultrasound treatment system with high intensity. A ultrasonic probe for finding position and a focused ultrasonic transducer are mounted on a bracket of five-dimensional accurate scanning device in treatment head in way of internal and external shaft sleeving. The treatment head is connected with an arm plate by revolving modules of the two sides and a set of pushpull modules and the arm plate is connected with a connecting plate by revolving shaft and arc track and the connecting plate is connected with an upright column by a straight guiderail, finally the three-dimensional locating device is obtained. The focused ultrasound treatment system with high intensity focuses the ultrasonic transducer to implement the upper to lower treatment mode. After three-dimensional locating, the system exactly locates, scanns, images and treats the focus of patient by the five-dimensional accurate scanning kinematic mechanism in the treatment head. The focused ultrasonic transducer can satisfy the different treatment attitudes from upper to lower and reduce the movement error during accurate scanning.

The invention relates to a layer stripping method in a chip failure analysis process, comprising the following steps: (1) providing a chip, the chip has a multi-layer structure, and includes at least one target analysis layer, and the target analysis layer includes a layer to be analyzed area; (2) using ion beams to carry out peeling treatment from the surface of the chip, remove one or more layers above the target analysis layer, and expose the area to be analyzed, wherein the ion The beam includes at least one broad ion beam with a beam spot diameter not less than 1 mm. In this peeling method, the ion beam formed by at least one wide-beam ion beam can be used to obtain a relatively uniform peeling surface, which avoids a single beam of high-energy focused ion beam directly hitting the surface of the chip, causing damage to the target analysis area. The precision of peeling is effectively improved, and the processing range is expanded at the same time, and the peeling efficiency is high.

A medical apparatus (600, 700, 800, 900) comprising a high intensity focused ultrasound system (602) configured for generating focused ultrasonic energy (612) for sonicating within a target volume (620) of a subject (601). The high intensity focused ultrasound comprises an ultrasonic transducer (606) with a controllable focus (618). The apparatus further comprises a memory (634) containing machine executable for controlling the medical apparatus and a processor (628) for executing the instructions. Execution of the instructions causes the processor to cause (100, 200, 300, 400, 502) ultrasonic cavitations at multiple cavitation locations (622, 1002) within the target volume using the high intensity focused ultrasound system. Execution of the instructions further cause the processor to sonicate (102, 206, 306, 402, 504) multiple sonication locations (1004) within the target volume using the high intensity focused ultrasound system. The multiple sonication locations and the multiple cavitation locations are targeted by adjusting the controllable focus.

The invention discloses a method for reducing the temperature error in magnetic resonance temperature imaging, which is used for the high-intensity focused ultrasound HIFU treatment monitored by magnetic resonance, the method comprises that: a reference image which is generated on two or more positions by an HIFU treatment head is carried out the interpolation, thus obtaining the reference image of the moving position of the HIFU treatment head; and the temperature change of a heating region is calculated according to a phase diagram of the interpolated reference image of the moving position of the HIFU treatment head and a heating image which is generated at the position by the HIFU treatment head. The invention further discloses a device for reducing the temperature error in the magnetic resonance temperature imaging, which comprises a reference image interpolation unit and a temperature calculation unit. The usage of the method and the device of the invention can significantly reduce the temperature error which is caused by the change of the magnetic susceptibility during the movement of the HIFU treatment head, which can not only obtain the accurate temperature change of the heating region, but also can reduce the complexity of the operation and the treatment time of the HIFU treatment.

The present invention discloses an imaging guided intelligentialized laser minimally invasive surgery system and a control method thereof. The intelligentialized laser minimally invasive surgery system includes a mechanical arm, a scanner, a video camera, a laser, a guiding light arm, a patient movable bed, and an information processing and control terminal. The imaging guided intelligentialized laser minimally invasive surgery system on the basis of the three-dimensional image information can precisely recognize the pigmented lesion region, strictly control the laser dose and irradiate laser on the pigmented lesion region so that the laser minimally invasive surgery is efficient, precious and safe, and the laser minimally invasive surgery system can automatically complete the surgery after acquiring sufficient patient information. The intelligentialized laser minimally invasive surgery system acts on human body surfaces, can be applied to the pigmented lesion laser minimally invasive surgery, is equipped with a visual servo system and a six-freedom light type mechanical arm, has the autonomy, and realizes the full automation. In addition, the intelligentialized laser minimally invasive surgery system has the strong expandability and can be applied to many minimally invasive surgeries based on human body surfaces, such as HIFU (high-intensity focused ultrasound) face-lift and wrinkle-remove surgery.

The invention relates to a preparation method and applications of a mesoporous calcium carbonate medicinal composition modified by hyaluronic acid, for effectively simultaneously realizing targeting, controlled release and ultrasonic therapy and ultrasonic imaging combination, and further realizing diagnosis and treatment integration on cancer. The technical scheme is as follows: the preparation method comprises the following steps: modifying hyaluronic acid on aminated calcium carbonate obtained by reacting mesoporous calcium carbonate and 3-aminopropyl triethoxysilane, and then loading a micromolecular sonosensitizer, thus obtaining the mesoporous calcium carbonate medicinal composition modified by hyaluronic acid. The preparation method has the advantages that a preparation process is simple, a method is stable and reliable, the production cost is low, and the prepared mesoporous calcium carbonate modified by hyaluronic acid and the medicinal composition of mesoporous calcium carbonate simultaneously have the efficacies of tumor targeting, in vitro and in vivo double-stimulation (in acid environment and under high-intensity focused ultrasonic condition) sensitive medicine release, sonodynamic therapy and ultrasonic imaging combined diagnosis and treatment integration, belong to an innovation in tumor treatment medicines, and have enormous economic and social benefits.

The invention discloses a novel optical fiber fabry-perot ultrasonic hydrophone and a manufacturing method thereof. The hydrophone can be used for measuring the high-intensity focusing acoustic field, and comprises optical fiber and a quartz capillary fused and spliced at the end part of the optical fiber; a high-reflective film is respectively plated at the end surface of the quartz capillary and the end surface of the optical fiber right against the quartz capillary; the outer diameter of the quartz capillary is identical to the outer diameter of single-mode optical fiber, and the inner diameter of the quartz capillary is smaller than the fiber core diameter of the single-mode optical fiber; if the inner diameter of the used quartz capillary is greater than the fiber core diameter of the optical fiber, the fusion splicing intensity can be properly enhanced, so that the front end of the quartz capillary is collapsed until the inner diameter of the quartz capillary is smaller than the fiber core diameter of the optical fiber. The novel optical fiber fabry-perot ultrasonic hydrophone has the advantages of simple structure, high interference signal, high intensity, high spatial resolution, high sensitivity and the like, and can bear high temperature and high sound pressure of an HIFU (high intensity focused ultrasound) sound field.

A medical apparatus (300, 400, 500) comprises a high intensity focused ultrasound system (322) configured for for sonicating a target volume (340) of a subject (318). The medical apparatus further comprises a magnetic resonance imaging system (302) for acquiring magnetic resonance data (356, 358, 360, 368, 374) from an imaging zone (308). The treatment volume is within the imaging zone. The medical apparatus further comprises a memory (352) containing machine executable,a control module (382, 402) for controlling the sonication of the target volume using the magnetic resonance data as a control parameter, and a processor (346). Execution of the instructions causes the processor to repeatedly acquire (102, 202) magnetic resonance data in real time using the magnetic resonance imaging system and control (104, 206) sonication of the target volume by the high intensity focused ultra-sound system in real time using the sonication control module and the magnetic resonance data.

An image monitor used in high-intensity focused ultrasonic therapy for real-time monitor to the injury of skin and hypoderm is composed of an imaging unit for taking the images of skin and hypoderm, an image acquiring unit for acquiring the data about said images, an analyzing and processing unit for storing said image data, comparing the data before treating with the data uring treating, and analyzing the injury, and a result display unit. Its method is also disclosed.

A device for thermal keratoplasty, the device comprising a plurality of ultrasonic transducers for emitting ultrasound waves, wherein the ultrasound waves of at least one of the transducers is focused on a corresponding area of the cornea in order to heat these area and cause collagen shrinkage and at least one of the transducers is capable of receiving ultrasound waves for ocular imaging.

The present invention relates to a method using transmitted and received signals for forming ultrasonic images for ultrasonic diagnosis, and to a high intensity focused ultrasonic therapeutic device performing same. The high intensity focused ultrasonic therapeutic device includes: a transmitting and receiving unit for transmitting ultrasonic waves for diagnosis to a subject and receiving an ultrasonic echo signal reflected from the subject to form a reception signal; an image processing unit for enabling a B-mode image to be formed on the basis of the reception signal, and outputting the B-mode image through a display unit therein; an ultrasonic wave generating unit for transmitting high intensity ultrasonic waves to a specific region of the subject; and a controller for controlling the transmitting and receiving unit and the ultrasonic wave generating unit to control the transmission periods of the ultrasonic waves for diagnosis and the high intensity ultrasonic waves on the basis of at least one or more pieces of information on the pulse repetition frequency (PRF) of the high intensity ultrasonic waves, the preset duty ratio, and the PRF disable signal generated by the ultrasonic wave generating unit.

A method for automatically selecting a region of interest covering a heated area, in the context of high intensity focused ultrasonic technology achieves automatic selection of the region of interest on the basis of the phase recognition completed in a magnetic resonance data acquisition and the position of the focus of a focused ultrasonic sensor. The method includes the steps of acquiring the phase data of a scanned area during a scanning process, then determining a heated area in the scanned area according to the phase data acquired; and in a displayed image acquired by the image reconstruction, demarcating a region of interest covering the heated area according to a predetermined size of said region of interest that covers and is larger than the heated area. The method causes the heated area to be automatically and completely included in the region of interest; and eliminates the instability of a manual selection of the region of interest, and the selection efficiency and accuracy of the region of interest are improved, so as to provide a basis for automatically achieving parameter-free selection.

The invention provides a chitosan nanometer micro-bubble and a preparation method and application thereof. The method comprises the steps of 1, preparing an acrylic acid aqueous solution, adding chitosan, heating the solution to 60-80 DEG C in the presence of protective gas after dissolution, adding an initiator for a reaction, then reducing the temperature of the solution for a reaction, conducting filtration and dialysis to remove impurities after the reaction is finished, adding a cross-linking agent for a reaction after processing is finished, conducting heating, and obtaining a nano-particle suspension after the reaction; 2, adding a freeze-drying protective agent into the nano-particle suspension, conducting freeze drying, and obtaining the chitosan nanometer micro-bubble. Accordingthe method, the chitosan is dissolved in the acrylic acid solution according to a certain proportion, the initiator is added to make acrylic acid and chitosan subjected to a polymerization reaction toobtain hollow nanoparticles internally containing water, water of the internal hollow structures is removed, and the obtained nanometer micro-bubble after being dissolved again has the synergistic effects on ultrasonic development and high-intensity focused ultrasonic tissue ablation.

The invention discloses a fluorocarbon emulsion auxiliary agent for increasing targeted area tissue energy deposition in HIFU treatment, which includes non-continuous phase constituted by filming material coating and continuous phase constituted by water-based medium, the non-continuous phase is dispersed in the continuous phase homogeneously, grain size of the non-continuous phase is 0.1-2um, the content of the film-forming material in the auxiliary agent is 0.1-100g / L, the core material is a liquid for generating liquid / gaseous phase change at 38-100 deg C, the content in the auxiliary agent is -200mg / L. The invention also discloses the use of the fluorocarbon emulsion auxiliary agent in HIFU treatment.