The invention discloses a multi-video real-time panoramic fusion splicing method based on a CUDA. The splicing method includes the step of system initialization and the step of real-time video frame fusion, wherein the step of system initialization is executed at the CPU end of the CUDA, and the step of real-time video frame fusion is executed at the GPU end; according to CUDA-based stream processing modes S21, S22, S23 and S24, four concurrent processed execution streams are set up at the GPU end, and S21, S22, S23 and S24 are deployed to corresponding stream processing sequences. Compared with the prior art, the multi-video and real-time panoramic fusion splicing method has the following advantages that multi-video real-time panoramic videos without ghost images or color brightness difference are achieved, the ultrahigh-resolution overall monitoring effect on large-scale scenes such as an airport, a garden and a square is remarkable, and the application prospect is wide.