Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration

A construct, biological technology, applied in the direction of human tubular structure devices, prostheses, antibodies, etc., can solve problems such as poor biological and physiological tolerance

Inactive Publication Date: 2011-06-01
杰伊·N·沙皮拉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] The novel "programmable" present invention aims to provide a method by adding nanophase surfaces to implantable devices capable of timed, qualitative and quantitative elute

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  • Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration
  • Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration
  • Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration

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Embodiment Construction

[0022] The following detailed description, set forth in conjunction with the accompanying drawings, is intended to describe presently preferred embodiments of the invention and is not intended to represent the only forms in which the invention may be constructed and / or utilized. These descriptions describe the function and sequence of steps for making and performing the invention in conjunction with the illustrated embodiments. However, it should be understood that the same or equivalent functions and sequences can be realized through different implementations, and the different implementations should also be covered within the spirit and scope of the present invention.

[0023] The present invention provides bioconstructs and methods for tissue remodeling and / or drug delivery following implantation of medical devices by utilizing a cytocompatible layered biocompatible polymeric biomatrix Optimally built with specialized surface textures with a particle size of up to 100 nm an...

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Abstract

The present invention relates to a biologically engineered construct, comprising a polymeric biomatrix (100) designed with a nanophase texture (106) and a therapeutic agent (104 or 300) for the purpose of tissue regeneration and/or controlled delivery of regenerative factors and therapeutic substances after it is implanted into tissues, vessels, or luminal structures within the body. The therapeutic agent (104 or 300) may be a therapeutic substance (104) or a biological agent (300), such as antibodies, ligands, or living cells. The nanophase construct is designed to maximize lumen size, promote tissue remodeling, and ultimately make the implant more biologically compatible. The nano-textured polymeric biomatrix (100) may comprise one or more layers containing therapeutic substances (104) and/or beneficial biological agents (300) for the purpose of controlled, physiological, differential substance/drug delivery into the luminal and abluminal surfaces of the vessel or lumen, and the attraction of target molecules/cells that will regenerate functional tissue. The topographic and biocompatible features of this layered biological construct provides an optimal environment for tissue regeneration along with a pro grammed -release, drug delivery system to improve physiological tolerance of the implant, and to maximize the cellular survival, migration, and integration within the implanted tissues.

Description

technical field [0001] The present invention relates to the use of bioengineered constructs to be used for tissue regeneration and controlled drug delivery after they have been implanted into tissues, blood vessels or luminal structures in the body. Background technique [0002] Millions of patients undergo the implantation of medical devices or drug delivery systems in the body in ocular, blood vessel, organ, bone, cartilage, muscle, catheter and / or luminal structures each year for the treatment of various diseases and in connection with these Disease-related complications. However, the cytocompatibility of these implants remains flawed. Implantation is often accompanied by risks of biorejection, cell migration, damaged, unnecessary and excessive tissue healing, development of blood clots on the device surface, or infection. This issue limits the application of currently available implantable biomaterials, drug delivery technologies, and cell therapy strategies. [0003]...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K39/395A61F2/04
CPCA61L2300/414A61L2300/64A61L27/54A61K9/167A61K9/1658A61L2300/426A61L2400/12A61K9/1641A61L2300/624A61L2300/61A61K9/1647A61L27/26A61K9/0085A61L2300/256A61K9/0024A61K9/1652A61K9/0014A61K9/0051
Inventor 杰伊·N·沙皮拉拉杰·马卡尔
Owner 杰伊·N·沙皮拉
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