Analogue of glucagon like peptide-1

A technology of glucagon and analogues, which is applied in the field of peptide analogues, can solve the problems of high price, complicated purification process, pollution, etc., and achieve the effect of maintaining the hypoglycemic time, definite hypoglycemic effect, and prolonging the half-life
CN102093475BInactive Publication Date: 2014-02-26吴晓琰 +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
吴晓琰
Publication Date
2014-02-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an analogue of glucagon like peptide-1(GLP-1), a medicinal composition comprising the GLP-1 analogue and a polypeptide (1-33) medicament. Compared with natural GLP-1, the polypeptide has the effect of reducing blood sugar, can be used for treating type 2 diabetes, can resist hydrolysis of DPPIV enzyme, can prolong action time and has a structure close to that of human-derived GLP-1 because three kinds of amino acid are added at one end of C and a structure at one end of N is changed into His-Gly(1-2). The invention also provides a medicinal composition comprising the polypeptide, which is produced through chemical synthesis and recombinant DNA. According to a gene engineering technique and a process for producing the polypeptide on a large scale, cost can be reduced and a new treatment medicament is provided for patients suffering from the type 2 diabetes.
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Description

technical field

[0001] The present invention relates to a polypeptide of the analogue of glucagon-like peptide-1 (GLP-1). The polypeptide has the effect of lowering blood sugar and can be used for treating type 2 diabetes. The invention also provides methods for producing these polypeptides by chemical synthesis and recombinant DNA production techniques. Background technique

[0002] Diabetes has become the third major chronic disease that seriously endangers human health after cardiovascular and cerebrovascular diseases and tumors. With the improvement of people's living standards, the incidence of diabetes has increased year by year and has evolved into a worldwide outbreak of epidemic diseases, and has a tendency to expand and rejuvenate. As the course of the disease progresses, patients may experience various complications, such as blindness, renal failure, limb gangrene, cardiovascular disease, and cerebrovascular accident. There are an estimated 20.8 million people w...

Claims

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