Total plasma FVII /FVIIA levels as indicators of pre-eclampsia of pregnant females

A pre-eclampsia, women's technology, applied in the field of total plasma FVII/FVIIA level as an indicator of pre-eclampsia in pregnant women, can solve the problem of not observing FVIIa

Inactive Publication Date: 2011-06-15
UNIV OF SOUTHAMPTON +1
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  • Abstract
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Problems solved by technology

In contrast, no similar changes were observed for FVIIa, TF or TFPI

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  • Total plasma FVII /FVIIA levels as indicators of pre-eclampsia of pregnant females
  • Total plasma FVII /FVIIA levels as indicators of pre-eclampsia of pregnant females
  • Total plasma FVII /FVIIA levels as indicators of pre-eclampsia of pregnant females

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Embodiment

[0015] Materials and methods

[0016] subjects

[0017]The Southampton and SouthWest Hants Local Research Ethics Committee granted ethics committee approval for the study. Informed consent has been obtained from all participants and relevant clinical details of each subject have been recorded. A total of 57 age-matched women were studied. These included healthy non-pregnant women (n=22; mean age=29±6.04), normal pregnant women (n=15; mean age=30.4±5.04), and women with P-EC (n=20; Mean age = 29.1 ± 5.59), which was in the third trimester of pregnancy. As noted above, severe P-EC was defined as diastolic blood pressure >110 mmHg on admission, or >90 mmHg on two or more consecutive occasions 4 hours apart; and proteinuria (>300 mg protein / day or urine protein / creatinine ratio >30mg / mmol). Healthy non-pregnant or normal pregnant women (control group) had systolic / diastolic blood pressure less than 120 / 80 mmHg and no history of hypertension or proteinuria. Common exclusion...

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Abstract

Raised total plasma FVII protein, including activated FVII (FVIIa) in pregnant females, compared with total plasma FVII protein in normal pregnancy, has been found to be an indicator of the pregnancy complication of pre-eclampsia.

Description

field of invention [0001] The present invention relates to the use of plasma factor VII (FVII) as a diagnostic marker for preeclampsia (P-EC) in pregnant women. More specifically, the invention relates to determining whether total plasma FVII protein, including detection of active FVII (FVIIa), is elevated compared to that found in normal pregnancy. This elevated FVII has been found in plasma samples from women with P-EC using a simple immunoassay to detect whether FVII and FVIIa are complexed with tissue factor. Background of the invention [0002] It is well established that the local hypercoagulable state is important for placental hemostasis during normal pregnancy. However, this is even more significant in the development of complications of preeclampsia, a complex multisystem disorder of unknown etiology. The frequent observation of small placental thrombi in women with P-EC suggests that predisposing factors for thrombosis, in addition to the thrombotic nature of th...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/86
CPCG01N2800/368G01N33/86G01N33/689
Inventor 巴希尔·A·卢瓦里德卢奇·玛丽亚·圣安娜·迪斯
Owner UNIV OF SOUTHAMPTON
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