Total plasma FVII /FVIIA levels as indicators of pre-eclampsia of pregnant females

A pre-eclampsia, women's technology, applied in the field of total plasma FVII/FVIIA level as an indicator of pre-eclampsia in pregnant women, can solve the problem of not observing FVIIa
CN102099686AInactive Publication Date: 2011-06-15UNIV OF SOUTHAMPTON +1

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF SOUTHAMPTON
Publication Date
2011-06-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

Raised total plasma FVII protein, including activated FVII (FVIIa) in pregnant females, compared with total plasma FVII protein in normal pregnancy, has been found to be an indicator of the pregnancy complication of pre-eclampsia.
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Description

field of invention

[0001] The present invention relates to the use of plasma factor VII (FVII) as a diagnostic marker for preeclampsia (P-EC) in pregnant women. More specifically, the invention relates to determining whether total plasma FVII protein, including detection of active FVII (FVIIa), is elevated compared to that found in normal pregnancy. This elevated FVII has been found in plasma samples from women with P-EC using a simple immunoassay to detect whether FVII and FVIIa are complexed with tissue factor. Background of the invention

[0002] It is well established that the local hypercoagulable state is important for placental hemostasis during normal pregnancy. However, this is even more significant in the development of complications of preeclampsia, a complex multisystem disorder of unknown etiology. The frequent observation of small placental thrombi in women with P-EC suggests that predisposing factors for thrombosis, in addition to the thrombotic nature of th...

Claims

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