Total plasma FVII /FVIIA levels as indicators of pre-eclampsia of pregnant females
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- UNIV OF SOUTHAMPTON
- Publication Date
- 2011-06-15
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
field of invention
[0001] The present invention relates to the use of plasma factor VII (FVII) as a diagnostic marker for preeclampsia (P-EC) in pregnant women. More specifically, the invention relates to determining whether total plasma FVII protein, including detection of active FVII (FVIIa), is elevated compared to that found in normal pregnancy. This elevated FVII has been found in plasma samples from women with P-EC using a simple immunoassay to detect whether FVII and FVIIa are complexed with tissue factor. Background of the invention
[0002] It is well established that the local hypercoagulable state is important for placental hemostasis during normal pregnancy. However, this is even more significant in the development of complications of preeclampsia, a complex multisystem disorder of unknown etiology. The frequent observation of small placental thrombi in women with P-EC suggests that predisposing factors for thrombosis, in addition to the thrombotic nature of th...