Medical dressing containing nano silver and carboxymethyl chitosan and preparation method thereof

A technology of carboxymethyl chitosan medicine and carboxymethyl chitosan, which is applied in the field of medical dressings containing nano-silver and carboxymethyl chitosan and its preparation, can solve problems such as limited application, and achieve avoidance of irritation, The effect of simple process and good antibacterial performance

Inactive Publication Date: 2011-07-06
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is only soluble in acidic conditions, which limits its application in medical dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1) Weigh 1 g of carboxymethyl chitosan and dissolve it in 50 ml of deionized water, stir it magnetically for 20 minutes to fully dissolve it, and prepare a carboxymethyl chitosan solution with a mass concentration of 2%.

[0017] (2) Add a certain amount of MES to the carboxymethyl chitosan solution until the concentration of MES is 0.1M, stir evenly and let stand for half an hour.

[0018] (3) Add 0.5 g of the mixture of EDC and NHS to the solution prepared in step (2), (wherein the ratio of EDC and NHS is 1:1), stir it for 40 seconds and pour it into a petri dish with a thickness of 150mm , forming carboxymethyl chitosan gel.

[0019] (4) Put the carboxymethyl chitosan gel in a constant temperature of 25° C. for 36 hours, take it out, pre-freeze at a low temperature for more than 12 hours, and freeze-dry to obtain a porous methyl chitosan film.

[0020] (5) Rinse the porous methyl chitosan membrane with a large amount of ultrapure water, and freeze-dry it for the se...

Embodiment 2

[0024] (1) Weigh 1 g of carboxymethyl chitosan and dissolve it in 50 ml of deionized water, stir it magnetically for 20 minutes to fully dissolve it, and prepare a carboxymethyl chitosan solution with a mass concentration of 2%.

[0025] (2) Add a certain amount of MES to the carboxymethyl chitosan solution until the concentration of MES is 0.1M, stir evenly and let stand for half an hour.

[0026] (3) Add 0.1 g of the mixture of EDC and NHS to the solution prepared in step (2), (the ratio of EDC and NHS is 1:1), stir it for 40 seconds and pour it into a petri dish with a thickness of 150mm , forming carboxymethyl chitosan gel.

[0027] (4) Put the carboxymethyl chitosan gel in a constant temperature of 25° C. for 36 hours, take it out, pre-freeze at a low temperature for more than 12 hours, and freeze-dry to obtain a porous methyl chitosan film.

[0028] (5) Rinse the porous methyl chitosan membrane with a large amount of ultrapure water, and freeze-dry it for the second tim...

Embodiment 3

[0032] (1) Weigh 1 g of carboxymethyl chitosan and dissolve it in 50 ml of deionized water, stir it magnetically for 20 minutes to fully dissolve it, and prepare a carboxymethyl chitosan solution with a mass concentration of 2%.

[0033] (2) Add a certain amount of MES to the carboxymethyl chitosan solution until the concentration of MES is 0.1M, stir evenly and let stand for half an hour.

[0034] (3) Add 1 g of the mixture of EDC and NHS to the solution prepared in step (2), (wherein the ratio of EDC and NHS is 1:1), and pour it into a petri dish after stirring for 40 s, with a thickness of 150 mm. Form carboxymethyl chitosan gel.

[0035] (4) Put the carboxymethyl chitosan gel in a constant temperature of 25° C. for 36 hours, take it out, pre-freeze at a low temperature for more than 12 hours, and freeze-dry to obtain a porous methyl chitosan film.

[0036] (5) Rinse the porous methyl chitosan membrane with a large amount of ultrapure water, and freeze-dry it for the secon...

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Abstract

The invention discloses a medical dressing containing nano silver and carboxymethyl chitosan and a preparation method thereof, which belong to the technical field of the preparation of biological materials for medical dressings. The preparation method comprises the following steps of: making water-soluble carboxymethyl chitosan form gel through biological activity crosslinking agent carbodiimide; preparing a porous carboxymethyl chitosan membrane by a freeze drying technology; soaking the porous carboxymethyl chitosan membrane in silver nitrate solution, and making silver ions adsorbed on the porous membrane; and making the silver ions form nano silver in the porous membrane in situ through ultraviolet illumination. The medical dressing containing the nano silver and the carboxymethyl chitosan has controllable permeability and mechanical properties and high and durable antibacterial properties.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical dressing biological materials, in particular to a medical dressing containing nano-silver and carboxymethyl chitosan and a preparation method thereof. Background technique [0002] Chitosan is the only cationic polysaccharide in nature with good biocompatibility. The essential properties of cations make them have strong antibacterial properties and can be used to prepare wound dressings. However, it is only soluble in acidic conditions, which limits its application in medical dressings. Carboxymethyl chitosan can dissolve under neutral conditions and retain the amino groups in chitosan without destroying its antibacterial properties. Nano-silver is considered as a non-toxic, environment-friendly material with good antibacterial properties, and is widely used in various antibacterial preparations. At present, there are many methods for preparing nano-silver, mainly including chemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44
Inventor 王常勇李俊杰
Owner INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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