Application of o-quinone structure-contained compounds in preparing tumor resistant medicament
A compound, o-quinone technology, applied in the field of anti-tumor compounds, can solve the problems of low content, unsatisfactory antibacterial and anti-tumor activity, etc.
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[0020] 1. Preparation of the series of compounds involved in the present invention.
[0021] The preparation method of the compound represented by general formula (I) involved in the present invention can be carried out with full reference to existing patents 200410077779.3, 200410077778.9 and WO 01 / 51004A2. According to the patent, we have synthesized compounds III-J1~6, V-J1~ 3. V-J6, VII-J1, VIII-J1, IV-J2~6, VI-J2, VI-J3, VI-J6 compounds, the compound spectrum data obtained are the same as the above patent results, and will not be listed here out.
[0022] Compound structures and corresponding numbers are as follows:
[0023]
[0024] VIII-J1: R1=Cl, R2=CH3, R3=OCOPh VII-J1: R1=H, R2=CH3, R3=H
[0025]
[0026] D-1 D-2 D-3 D-4 D-5
[0027] 2. Cytotoxic activity test experiment
[0028] Cytotoxic activity of the synthesized compounds III-J1~6, V-J1~3, V-J6, VII-J1, VIII-J1, IV-J2~6, VI-J2, VI-J3, VI-J6 Test, with 10-hydroxycamptothecin, mansononeF, etoposide an...
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