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Curcumin or curcumin-ramification-containing composite feed additive and use thereof

A technology of curcumin derivatives and compound feed, applied in the direction of animal feed, animal feed, application, etc., can solve problems such as harm to the healthy development of aquaculture industry, economic losses of farmers, harm to aquaculture industry, etc., and to improve the problem of scale shedding. , avoid stress bleeding, reduce the effect of serum transaminase activity

Active Publication Date: 2011-07-27
HONGFENG CHEM GUAN COUNTY HEBEI PROV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In addition, "stress bleeding" occurs in the fish during the breeding process ("stress bleeding" is due to the increase in the permeability of the blood vessel wall in the body and the exudation of blood due to external environmental stimuli such as pulling nets, fishing, and transportation. Hemorrhagic symptoms), "hairy" fish body, that is, scales are loose, easy to fall off, and mucus is missing. This is a prominent problem that endangers the aquaculture industry at present, and it also brings huge economic losses to farmers. Healthy Development of Aquaculture Industry

Method used

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  • Curcumin or curcumin-ramification-containing composite feed additive and use thereof
  • Curcumin or curcumin-ramification-containing composite feed additive and use thereof
  • Curcumin or curcumin-ramification-containing composite feed additive and use thereof

Examples

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Embodiment 1

[0123] Curcumin was purchased from Xi'an Yinghua Biotechnology Co., Ltd., trade name: turmeric extract, wherein the content of curcumin was 95.36%, and it was a yellow powder.

Embodiment 2

[0125] The curcumin, demethoxycurcumin, and bisdemethoxycurcumin are curcumin compounds, and the synthesis method adopts Hu Xinlong (Zhejiang University of Technology, 2007 dissertation) "extraction, separation, chemical modification and Research on the antitumor activity of its derivatives” reports that curcumin contains a part of volatile oil components, and curcumin is insoluble in water, so you can use a volatile oil extractor to remove fat-soluble substances such as volatile oil, and then use ethanol solution as an extraction solvent to extract Sichuan Curcuma longa powder, to obtain curcumin. The process is attached Figure 5 .

[0126] Process conditions: first remove the volatile oil, soak for 24 hours, the particle size of the turmeric powder is medium (20-30 mesh), the extraction time is 1.5 hours, the solid-to-liquid ratio is 1:5, after removing the volatile oil, continue to extract with 75% ethanol for 3 h, when the liquid-solid ratio is 6:1, the total curcumin i...

Embodiment 3

[0128] The preparation method of described curcumin aromatic ring derivative:

[0129] Dissolve 200ng curcumin (1.62mmol) in 40ml acetone, add 4ml ethyl chloroacetate, 40mgNaI and 314mg anhydrous potassium carbonate, and heat to reflux for 24h. Filtrate, concentrate the solution, purify with silica gel column chromatography, eluent is cyclohexane / ethyl acetate / ethanol (V(C 6 h 12 ):V(CH 3 COOC 2 h 5 ):V(C 2 h 5 OH))=4:5:1, 229 mg of curcumin ethyl dicarbonate was obtained, and the yield was 78%. Dissolve 200g in 20ml acetone / water (V(CH 3 COCH 3 ):V(H 2 O))=4:1), add 22mg KOH, keep stirring, until TLC detects that curcumin ethyl dicarbonate reacts completely. Acidify the reaction solution with dilute hydrochloric acid, distill off acetone, and extract with ethyl acetate, collect the ethyl acetate layer, dry with anhydrous sodium sulfate, distill off the solvent, and use V(C 2 h 5 OH):V(H 2 O) = 2:1 recrystallization to obtain 177 mg of curcumin dicarbonate, yellow...

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Abstract

The invention relates to a curcumin or curcumin-ramification-containing composite feed additive and a use thereof. The use of the additive can promote the growth of the animals, and / or protect the livers of the animals, and / or improve the oxidation resistance of the animals, reduce the generation of lipid peroxide, and improve the immunity and the disease resistance, and / or improve the stress resistance of the fish, avoid the problem of 'irritable haemorrhage', promote the secretion of fish mucus, and solve the problems that the cultivated fish is easy to loosen squama, easy to fall off, and lack of fish mucus. The invention further relates to a method for cultivating the animals and an animal feed which contains the composite feed additive having the curcumin or curcumin ramification.

Description

[0001] technical field [0002] The invention relates to a compound feed additive containing curcumin or curcumin derivatives, in particular to a compound feed additive for protecting the liver and improving the stress resistance of animals, and also relates to its use as an animal feed additive. Background technique [0003] In China, with the improvement of breeding management technology, there are more and more diseases and difficult diseases of farmed aquatic animals, especially fatty liver disease in different breeding areas, different breeding aquatic animals, and different breeding periods in China. High probability of occurrence; (1) Fatty liver disease (FLD) is prone to occur in aquaculture animals, especially farmed fish, especially fish that eat feed and chilled fish. The type of disease with the highest incidence and greatest impact; (2) There are many factors that cause fatty liver disease in farmed fish, such as the deterioration of the environment in the cultu...

Claims

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Application Information

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IPC IPC(8): A23K1/16A23K1/14A23K10/37A23K20/10A23K20/174A23K20/179
CPCY02P60/87
Inventor 萧培珍张宝彤叶元土张波裴双秀
Owner HONGFENG CHEM GUAN COUNTY HEBEI PROV
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