Nano complex particles with targeted MR (magnetic resonance) development and photothermal therapy performance and preparation method thereof
A nanocomposite and photothermotherapy technology, which is applied to medical preparations containing active ingredients, wave energy or particle radiation treatment materials, preparations for in vivo experiments, etc., can solve the problem of high recurrence rate and difficult therapeutic effect. Evaluation, difficult early diagnosis and discovery of tumors, etc., to achieve clear effects, no chemotherapy side effects, and large demand
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0037] Example 1:
[0038] Decomposition of FeCl in Chitosan Solution by Hydrothermal Synthesis 3 ·6H 2 O prepared from Fe 3 O 4 Fe composed of oriented-attached single crystal 3 O 4 Crystal clusters (CNCs), because the surface layer of chitosan is rich in amino groups, has a good coordination ability for transition metals, use the seed growth method to grow gold nanoshells on the surface of CNCs, and then modify the antibody molecules on the surface of the gold shells, and finally prepare Nanocomposite particles (CNCs@Au@EGRF) with tumor-targeted MR imaging and photothermal therapy performance. Specific steps are as follows:
[0039] Step (a) Fe 3 O 4 Preparation of colloidal nanocrystal clusters (CNCs):
[0040] Dissolve ferric chloride (1.35g, 5mmol) in 40mL of ethylene glycol and stir to obtain a clear solution, then add 3.6g of sodium acetate and 1g of chitosan (molecular weight 5000), stir for 30min and seal in 50mL with polytetrafluoroethylene The reaction was carried out at...
Example Embodiment
[0047] Example 2:
[0048] Step (a): Dissolve ferric chloride (1.35g, 5mmol) in 40mL of ethylene glycol and stir to obtain a clear solution, then add 3.6g of sodium acetate and 2g of chitosan (molecular weight 10000), stir for 30min and seal in 50mL tape React 8h at 220□C in a reactor with PTFE liner. After the reaction solution was cooled to room temperature, it was centrifuged and washed with ethanol to obtain a black product, and CNCs with a diameter of about 90 nm were obtained.
[0049] Step (b): Put 2.5mL HAuCl 4 (20mM) solution was added to 10mL CNCs (1mg mL), sonicated for 30min at room temperature, then quickly added a 3-fold excess of KBH4 and stirred vigorously for 3min, separated and washed by an external magnetic field to prepare CNCs@Au seeds, and re-diluted to 1mg mL of solution is ready for use.
[0050] Step (c): Add CNCs@Au seeds (1mL), HAuCl 4 (20mM, 2mL) solution and Na 2 CO 3 (20mM, 5mL) solution is placed in a 25mL flask, and magnetically stirred at high speed...
PUM
Property | Measurement | Unit |
---|---|---|
Diameter | aaaaa | aaaaa |
Diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap