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Pranlukast injection preparation

A technology for injection preparations and alcohol solvents, which is applied in the field of small-volume injection preparations and can solve the problems of low bioavailability and low solubility of prankast

Inactive Publication Date: 2011-09-14
CHONGQING HUIZHI PHARMA RES INST +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of this, the present invention provides a kind of prankast injection preparation, especially a kind of injection preparation of small volume, can effectively solve the low problem of the low solubility of prankast and thoroughly overcome the low bioavailability of traditional oral preparations

Method used

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  • Pranlukast injection preparation
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Examples

Experimental program
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Effect test

Embodiment 1-20

[0015] Examples 1-20: Small-volume injections of pranlukast with different basic ingredients, the composition of which is shown in Table 1.

[0016] Preparation:

Embodiment 1-12

[0017] Example 1-12: Dissolve the basic component in a small amount of water for injection, then add pranlukast and the aqueous solution of the basic component into the alcoholic solvent, stir and dissolve (can be heated at ≤80°C), and cool to room temperature , adjust the pH to 7.0-7.6 with 0.1N hydrochloric acid, add water for injection to 50ml, filter until clear, fill with 50mg / 5ml, and sterilize at 100°C for 30min.

Embodiment 13-16

[0018] Examples 13-16: Add pranlukast and 10% ammonia water into an alcoholic solvent, stir to dissolve (it can be heated at ≤80°C), and cool to room temperature. Add 10mg of activated carbon, stir evenly and let it stand for 15min. After decarburization by coarse filtration, adjust the pH to 7.0-7.6 with 0.1N hydrochloric acid, add water for injection to 50ml, filter until clear, potting at 50mg / 5ml, and sterilize at 100°C Serve in 30 minutes.

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Abstract

The invention relates to a pranlukast injection preparation. In the invention, an alcohols solvent which can be accepted in drugs contains effective doses of pranlukast and alkaline constituents allowed to be used in the needed drugs which can fully convert the pranlukast into water soluble salt, wherein the weight ratio of the pranlukast to the alcohols solvent is 1: (7-70) and the pH (potential of Hydrogen) value of the injection preparation is 3-10. By utilizing the injection preparation, the problems that the pranlukast has low solubility and the bioavailability of a traditional oral preparation is low are effectively and thoroughly solved; the concentration of the pranlukast in the injection preparation can reach 1%; and therefore, the drug dosage can be greatly decreased, the preparation is convenient to prepare and the drug cost is reduced.

Description

technical field [0001] The invention relates to a pranlukast injection preparation, in particular to a small volume injection preparation. Background technique [0002] Pranlukast, the chemical name is 4-oxo-8-(4-(4-phenylbutoxy)benzamido)-2-(tetrazol-5-yl)-4H-1 - Benzopyran and its hydrates, which are leukotriene receptor antagonists, are suitable for various types of asthma, including atopic, mixed, infectious, paroxysmal, chronic and non-seasonal bronchial asthma, It can also be used for allergic rhinitis and allergic eye diseases. Prankast is a leukotriene receptor antagonist (LTRA), which can significantly inhibit LTC4, LTD4, and LTE4, especially for LTD4 (the main component that causes the contraction of human tracheal smooth muscle), and can reduce lymphocytes. Infiltration of bronchial mucosa, reducing bronchial hyperresponsiveness, preventing exacerbation of asthma when high doses of inhaled glucocorticoids are reduced. [0003] Prankast is notable for being prac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/41A61K47/34A61K47/18A61K47/10A61K47/02A61P37/08A61P11/02A61P27/14A61K47/26
Inventor 姜维平周艳婷
Owner CHONGQING HUIZHI PHARMA RES INST
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