Pranlukast injection preparation

A technology for injection preparations and alcohol solvents, which is applied in the field of small-volume injection preparations and can solve the problems of low bioavailability and low solubility of prankast
CN102178647AInactive Publication Date: 2011-09-14CHONGQING HUIZHI PHARMA RES INST +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING HUIZHI PHARMA RES INST
Publication Date
2011-09-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a pranlukast injection preparation. In the invention, an alcohols solvent which can be accepted in drugs contains effective doses of pranlukast and alkaline constituents allowed to be used in the needed drugs which can fully convert the pranlukast into water soluble salt, wherein the weight ratio of the pranlukast to the alcohols solvent is 1: (7-70) and the pH (potential of Hydrogen) value of the injection preparation is 3-10. By utilizing the injection preparation, the problems that the pranlukast has low solubility and the bioavailability of a traditional oral preparation is low are effectively and thoroughly solved; the concentration of the pranlukast in the injection preparation can reach 1%; and therefore, the drug dosage can be greatly decreased, the preparation is convenient to prepare and the drug cost is reduced.
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Description

technical field

[0001] The invention relates to a pranlukast injection preparation, in particular to a small volume injection preparation. Background technique

[0002] Pranlukast, the chemical name is 4-oxo-8-(4-(4-phenylbutoxy)benzamido)-2-(tetrazol-5-yl)-4H-1 - Benzopyran and its hydrates, which are leukotriene receptor antagonists, are suitable for various types of asthma, including atopic, mixed, infectious, paroxysmal, chronic and non-seasonal bronchial asthma, It can also be used for allergic rhinitis and allergic eye diseases. Prankast is a leukotriene receptor antagonist (LTRA), which can significantly inhibit LTC4, LTD4, and LTE4, especially for LTD4 (the main component that causes the contraction of human tracheal smooth muscle), and can reduce lymphocytes. Infiltration of bronchial mucosa, reducing bronchial hyperresponsiveness, preventing exacerbation of asthma when high doses of inhaled glucocorticoids are reduced.

[0003] Prankast is notable for being prac...

Claims

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