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Bioactive orthopaedic implant constituent

A composition and orthopedic technology, applied in medical science, prosthesis, etc., can solve problems such as difficult control of aging time

Active Publication Date: 2011-10-12
CENT MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another example is US-6,593,394, which uses strontium phosphate (strontium phosphate) and Bis-GMA resin (Bisphenol A diglycidylether dimethacrylate resin) to form bioactive bone cement (bioactive bone cement), but the curing time of the composition Not easy to control is the biggest disadvantage

Method used

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  • Bioactive orthopaedic implant constituent
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] With 9.0 grams of calcium sulfate hemihydrate (purchased from Taiwan Central Medical Co., Ltd., product name Osteo-G, the same below), and 1.0 gram of Sr / CaHA (manufactured according to the method described in US-6,593,394, the same below), wherein the Sr The strontium content of / CaHA is 20 mol%, and the calcium content is 80 mol%, add 3 milliliters of water to prepare a slurry, and then mold it into a small cylindrical (d=2.4mm, l=5.0mm) implant. The implants were implanted in the tibiae of 8-week-old female SD rats.

[0041] Twelve weeks after implantation, tissue sections at the implantation site were taken out for Giemsa and Eosin surface stain analysis, and Modified Mc.Nealtetrachrome stain analysis. For the results, see Figure 1A , 1B . Figure 1A Among them, the left side (label 110) is the old bone (original bone), and the right side (label 120) is the new bone (new bone), showing that new bone has indeed grown; Figure 1B In the old bone (140) near the impla...

Embodiment 2

[0043] With 8.0 grams of calcium sulfate hemihydrate, and 2.0 grams of Sr / CaHA (Sr=10mol%, Ca=90mol%), add 3 milliliters of water to adjust to slurry, then molded into small cylindrical shape (d=2.4mm, l= 5.0mm) implants. The implants were implanted in the tibiae of 8-week-old SD female mice (Sprague-Dawley Rat).

[0044] Twelve weeks after implantation, tissue sections at the implantation site were taken out for Giemsa and Eosin surface stain analysis and Modified Mc.Nealtetrachrome stain analysis. For the results, see Figure 2A , 2B . Figure 2A , 2B Similar to Figures 1E and 1F, it shows that the implant has bone inductive effect on bone, not just bone conductive effect.

Embodiment 3～5

[0046] Similar to Example 2, but the formulation of the composition is shown in Table 1:

[0047] Table 1: Implant composition of Examples 3-5

[0048]

[0049] The Kimsey / eosin staining analysis is as follows image 3 , Figure 4 , Figure 5 As shown, all show that the implant has an osteoinductive effect on the bone.

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Abstract

The invention relates to a bioactive orthopaedic implant constituent, particularly relates to a bioactive orthopaedic implant constituent which can induce cell growth. The bioactive orthopaedic implant constituent comprises 2-70 wt % of strontium / calcium phosphate and 30-98 wt % of calcium sulfate, wherein the strontium (molar ratio) accounts for 2.5%-40% of the total amount of the strontium / calcium phosphate, and the weight percentage (wt %) is calculated based on the sum of weights of the strontium / calcium phosphate and the calcium sulfate.

Description

technical field [0001] The invention relates to a bioactive orthopedic filling composition, especially a bioactive orthopedic filling composition that can induce cell growth. Background technique [0002] Traditional orthopedic fillers, such as TW-I227146 (equivalent to US-6,251,139, CN-1306865), although have the effect of promoting bone cell growth, but the effect is relatively weak, so in patients with osteoporosis, fillers often appear A condition in which the rate of resorption is greater than the rate at which bone cells are promoted. Another example is US-6,593,394, which uses strontium phosphate (strontium phosphate) and Bis-GMA resin (Bisphenol A diglycidylether dimethacrylate resin) to form bioactive bone cement (bioactive bone cement), but the curing time of the composition Not easy to control is the biggest disadvantage. Contents of the invention [0003] An object of the present invention is to provide a bioactive orthopedic filling composition. [0004] An...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/54
Inventor 林智一林圣富
Owner CENT MEDICAL TECH